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Byung Il Lee

Korea University · Medicine

About the Lab

Professor Byung Il Lee's research lab focuses on translational biomedical research, particularly in cancer biology and neurodegenerative diseases such as Alzheimer’s disease. The lab investigates epigenetic regulation in cancer, including histone deacetylase inhibitors as potential therapeutics, and explores photochemical approaches to inhibit amyloid aggregation in Alzheimer’s disease using molecules like MS-275, methylene blue, and porphyrins. Additionally, the lab contributes to medical imaging technology, notably magnetic resonance electrical impedance tomography (MREIT), for non-invasive tissue conductivity imaging. Their interdisciplinary work bridges molecular biology, structural biology, and biomedical engineering to develop novel therapeutic and diagnostic strategies.

cancer epigeneticsAlzheimer’s diseasephotochemical therapyMREITamyloid inhibition

Research Overview

Papers
171
Total Citations
2,019
Papers (5y)
13
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
13total
2022
2023
2024
2025
2026
Citations per year (5y)
79total
20222023202420252026

Selected Papers

15
1
Article|115 citations·2015
Photoexcited Porphyrins as a Strong Suppressor of β‐Amyloid Aggregation and Synaptic Toxicity
Byung Il Lee, Seongsoo Lee, Yoon Seok Suh, Joonseok Lee, Ae‐Kyeong Kim, O‐Yu Kwon, Kweon Yu, Chan Beum Park
SJR Q1Angewandte Chemie International Edition

The abnormal assembly of β-amyloid (Aβ) peptides into neurotoxic, β-sheet-rich amyloid aggregates is a major pathological hallmark of Alzheimer's disease (AD). Light-induced photosensitizing molecules can regulate Aβ amyloidogenesis. Multiple photochemical analyses using circular dichroism, atomic force microscopy, dot blot, and native gel electrophoresis verified that photoactivated meso-tetra(4-sulfonatophenyl)porphyrin (TPPS with M = 2H(+), Zn(2+), Cu(2+), Mn(2+)) successfully inhibits Aβ agg

PharmacologyMedicine
2
Review|99 citations·2018
Photosensitizing materials and platforms for light-triggered modulation of Alzheimer's β-amyloid self-assembly
Byung Il Lee, You Jung Chung, Chan Beum Park
SJR Q1Biomaterials
PharmacologyMedicine
3
Article|80 citations·2003
Three-dimensional forward solver and its performance analysis for magnetic resonance electrical impedance tomography (MREIT) using recessed electrodes
Byung Il Lee, Suk Hoon Oh, Eung Je Woo, Soo Yeol Lee, Min Hyoung Cho, Oh In Kwon, Jin Keun Seo, June‐Yub Lee, Woon Sik Baek
SJR Q1Physics in Medicine and Biology

In magnetic resonance electrical impedance tomography (MREIT), we try to reconstruct a cross-sectional resistivity (or conductivity) image of a subject. When we inject a current through surface electrodes, it generates a magnetic field. Using a magnetic resonance imaging (MRI) scanner, we can obtain the induced magnetic flux density from MR phase images of the subject. We use recessed electrodes to avoid undesirable artefacts near electrodes in measuring magnetic flux densities. An MREIT image r

Electrical and Electronic EngineeringEngineering
4
Article|44 citations·2003
Static resistivity image of a cubic saline phantom in magnetic resonance electrical impedance tomography (MREIT)
Byung Il Lee, Suk Hoon Oh, Eung Je Woo, Soo Yeol Lee, Min Hyoung Cho, Oh In Kwon, Jin Keun Seo, Woon Sik Baek
SJR Q2Physiological Measurement

In magnetic resonance electrical impedance tomography (MREIT) we inject currents through electrodes placed on the surface of a subject and try to reconstruct cross-sectional resistivity (or conductivity) images using internal magnetic flux density as well as boundary voltage measurements. In this paper we present a static resistivity image of a cubic saline phantom (50 x 50 x 50 mm3) containing a cylindrical sausage object with an average resistivity value of 123.7 ohms cm. Our current MREIT sys

Electrical and Electronic EngineeringEngineering
5
Article|18 citations·2006
Optimization of current injection pulse width in MREIT
Byung Il Lee, Chunjae Park, Hyun Chan Pyo, Oh In Kwon, Eung Je Woo
SJR Q2Physiological Measurement

In magnetic resonance electrical impedance tomography (MREIT), we inject electrical current into a volume conductor to induce a distribution of magnetic flux density. By measuring the internal magnetic flux density using an MR scanner, we reconstruct images of cross-sectional conductivity and current density distributions. One of the most important technical problems in MREIT is to reduce the noise level in the measured magnetic flux density data since it limits the quality of reconstructed imag

Electrical and Electronic EngineeringEngineering
6
Article|15 citations·2015
Photoexcited Porphyrins as a Strong Suppressor of β‐Amyloid Aggregation and Synaptic Toxicity
Byung Il Lee, Seongsoo Lee, Yoon Seok Suh, Joonseok Lee, Ae‐Kyeong Kim, O‐Yu Kwon, Kweon Yu, Chan Beum Park
Angewandte Chemie

Abstract The abnormal assembly of β‐amyloid (Aβ) peptides into neurotoxic, β‐sheet‐rich amyloid aggregates is a major pathological hallmark of Alzheimer’s disease (AD). Light‐induced photosensitizing molecules can regulate Aβ amyloidogenesis. Multiple photochemical analyses using circular dichroism, atomic force microscopy, dot blot, and native gel electrophoresis verified that photoactivated meso ‐tetra(4‐sulfonatophenyl)porphyrin (TPPS with M=2H + , Zn 2+ , Cu 2+ , Mn 2+ ) successfully inhibit

PharmacologyMedicine
7
Article|12 citations·2006
Basic setup for breast conductivity imaging using magnetic resonance electrical impedance tomography
Byung Il Lee, Suk Hoon Oh, Tae-Seong Kim, Eung Je Woo, Soo Yeol Lee, Oh In Kwon, Jin Keun Seo
SJR Q1Physics in Medicine and Biology

We present a new medical imaging technique for breast imaging, breast MREIT, in which magnetic resonance electrical impedance tomography (MREIT) is utilized to get high-resolution conductivity and current density images of the breast. In this work, we introduce the basic imaging setup of the breast MREIT technique with an investigation of four different imaging configurations of current-injection electrode positions and pathways through computer simulation studies. Utilizing the preliminary find

Electrical and Electronic EngineeringEngineering
8
Article|10 citations·2012
Versatile Use of Submental Tissue for Reconstruction of Perioral Soft Tissue Defects
Seong‐Ho Jeong, Byung Il Lee
SJR Q2Journal of Craniofacial Surgery

To obtain optimum aesthetic result, perioral soft tissue defects require reconstruction using similar tissue. The submental area has very similar characteristics to perioral soft tissue and consists of thin, pliable tissue with a perfect color match. Therefore, we have used submental tissues for reconstruction of perioral soft tissue defects and application of the techniques, and results are discussed in this article. Between February 2001 and April 2008, 14 perioral soft tissue reconstruction p

SurgeryMedicine
9
Article|6 citations·2006
Phase artefact reduction in magnetic resonance electrical impedance tomography (MREIT)
Byung Il Lee, Chunjae Park, Hyun Chan Pyo, Oh In Kwon, Eung Je Woo
SJR Q1Physics in Medicine and Biology

Cross-sectional conductivity imaging in magnetic resonance electrical impedance tomography (MREIT) requires the measurement of internal magnetic flux density using an MRI scanner. Current injection MRI techniques have been used to induce magnetic flux density distributions that appear in phase parts of the obtained MR signals. Since any phase error, as well as noise, deteriorates the quality of reconstructed conductivity images, we must minimize them during the data acquisition process. In this

Electrical and Electronic EngineeringEngineering
10
Article|5 citations·2002
Three-dimensional forward problem in magnetic resonance electrical impedance tomography (MREIT)
Byung Il Lee, Suk Hoon Oh, Eung Je Woo, Soo Yeol Lee, Min Hyoung Cho, Oh In Kwon, Jeong‐Rock Yoon, Jin Keun Seo

In MREIT, we reconstruct cross-sectional resistivity images of a subject. Injecting currents through surface electrodes, we measure internal magnetic flux density using MRCDI technique. Current density can be obtained from the magnetic flux density data. For resistivity image reconstruction algorithms, we need a three-dimensional forward solver computing voltage, current density, and magnetic flux density within the subject. Given injection currents as boundary conditions, the three-dimensional

Electrical and Electronic EngineeringEngineering
11
Article|3 citations·1999
Determination of the Degree of Gelatinization of Cooked Rice and Its Effect on the Enzyme Activity of the Korean Gokja Grown with Aspergillus oryzae
Byung Il Lee, Sungwon Yoon, Cherl‐Ho Lee
SJR Q2Food Science and Biotechnology
Food ScienceAgricultural and Biological Sciences
12
Article|3 citations·2014
Analysis of Lattice Temperature in Super Junction Trench Gate Power MOSFET as Changing Degree of Trench Etching
이병일, 금종민, 정은식, 강이구, 김용태, 성만영
JOURNAL OF SEMICONDUCTOR TECHNOLOGY AND SCIENCE

Super junction trench gate power MOSFETs have been receiving attention in terms of the trade-off between breakdown voltage and on-resistance [1]. The vertical structure of super junction trench gate power MOSFETs allows the on-resistance to be reduced compared with conventional Trench Gate Power MOSFETs. The heat release of devices is also decreased with the reduction of on-resistance. In this paper, Lattice Temperature of two devices, Trench Gate Power MOSFET and Super junction trench gate powe

13
paratext|2 citations·2015
Cover Picture: Photoexcited Porphyrins as a Strong Suppressor of β‐Amyloid Aggregation and Synaptic Toxicity (Angew. Chem. Int. Ed. 39/2015)
Byung Il Lee, Seongsoo Lee, Yoon Seok Suh, Joonseok Lee, Ae‐Kyeong Kim, O‐Yu Kwon, Kweon Yu, Chan Beum Park
SJR Q1Angewandte Chemie International Edition

Photoexcited porphyrin molecules inhibit β-amyloid aggregation and rescue postsynaptlc toxicity and behavior defects in the Drosophila Alzheimer’s disease model under blue light. In their Communication on page 11472 ff., C. B. Park, K. Yu et al. present a chemical strategy for photodynamic suppression of β-amyloid aggregation using photosensitizing molecules. Photoexcited porphyrin molecules inhibit β-amyloid aggregation and rescue postsynaptlc toxicity and behavior defects in the Drosophila Alz

PharmacologyMedicine
14
Article|1 citations·2011
Pyrogallin, an ATP-Competitive Inhibitor of JAK3
Byung Il Lee, H.C. Ahn, Ki-Cheol Han, Dae‐Ro Ahn, Dongyun Shin
SJR Q2Bulletin of the Korean Chemical SocietyOA
OncologyMedicine
15
Article|0 citations·2017
Analysis Method on the Public Evacuation Response System during a Radiological Emergency using System Dynamics
Byung Il Lee, Min Ho
Korean System Dynamics Review
Organizational Behavior and Human Resource ManagementBusiness, Management and Accounting

Research Areas

SurgeryElectrical and Electronic EngineeringPharmacologyOncologyEpidemiologyRadiology, Nuclear Medicine and Imaging

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