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Chan Wook Park

Seoul National University · Medicine

About the Lab

Professor Chan Wook Park's research lab specializes in perinatal inflammation and its implications in preterm birth, focusing on the role of inflammatory biomarkers such as matrix metalloproteinase-8 (MMP-8) in amniotic fluid. The lab investigates the pathogenesis of intra-amniotic inflammation, funisitis, and chorioamnionitis in preterm pregnancies, particularly in the context of preterm labor and preterm prelabor rupture of membranes. Key research directions include the clinical significance of inflammatory markers as predictors of adverse outcomes and the development of rapid bedside tests like the MMP-8 PTD Check for early risk assessment. The lab also explores the qualitative and quantitative relationships between fetal, maternal, and placental inflammatory responses.

intra-amniotic inflammationpreterm birthfetal inflammationbiomarkers in amniotic fluidMMP-8

Research Overview

Papers
309
Total Citations
4,156
Papers (5y)
69
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
69total
2021
2022
2023
2024
2025
Citations per year (5y)
424total
20212022202320242025

Selected Papers

15
1
Article|204 citations·2003
The relationship between product involvement and product knowledge: Moderating roles of product type and product knowledge type
Chan‐Wook Park, Byeong‐Joon Moon
SJR Q1Psychology and Marketing

Abstract To shed further light on the correlation between consumer product involvement and consumer product knowledge, the authors examined such correlation by treating product type and product knowledge type as moderating variables. The results show that the correlation between a consumer's product involvement and objective product knowledge is higher in a utilitarian product than in a hedonic product. On the contrary, the correlation between a consumer's product involvement and subjective prod

MarketingBusiness, Management and Accounting
2
Article|121 citations·2008
The Involvement of Human Amnion in Histologic Chorioamnionitis is an Indicator that a Fetal and an Intra-Amniotic Inflammatory Response is More Likely and Severe: Clinical Implications
Chan‐Wook Park, Kyung Chul Moon, Joong Shin Park, Jong Kwan Jun, Roberto Romero, Bo Hyun Yoon
SJR Q1PlacentaOA
EpidemiologyMedicine
3
Article|94 citations·2005
An elevated maternal plasma, but not amniotic fluid, soluble fms-like tyrosine kinase-1 (sFlt-1) at the time of mid-trimester genetic amniocentesis is a risk factor for preeclampsia
Chan‐Wook Park, Joong Shin Park, Soon‐Sup Shim, Jong Kwan Jun, Bo Hyun Yoon, Roberto Romero
SJR Q1American Journal of Obstetrics and Gynecology
Obstetrics and GynecologyMedicine
4
Article|69 citations·2008
The antenatal identification of funisitis with a rapid MMP-8 bedside test
Chan‐Wook Park, Seung Mi Lee, Joong Shin Park, Jong Kwan Jun, Roberto Romero, Bo Hyun Yoon
SJR Q2Journal of Perinatal MedicineOA

The MMP-8 PTD Check is a rapid, simple and sensitive bedside test which allows assessment of the risk of funisitis.

EpidemiologyMedicine
5
Article|41 citations·2019
The relationship among the progression of inflammation in umbilical cord, fetal inflammatory response, early-onset neonatal sepsis, and chorioamnionitis
Jeong‐Won Oh, Chan‐Wook Park, Kyung Chul Moon, Joong Shin Park, Jong Kwan Jun
SJR Q1PLoS ONEOA

FIR, EONS and chorioamnionitis continuously increase according to the progression of inflammation in UC among preterm-gestations with inflammation in extraplacental membranes or CP. This finding may suggest that funisitis(inflammation in UC) is both qualitatively and quantitatively histologic-counterpart of FIRS, and a surrogate-marker for chorioamnionitis.

EpidemiologyMedicine
6
Article|31 citations·2013
Fetal, amniotic and maternal inflammatory responses in early stage of ascending intrauterine infection, inflammation restricted to chorio-decidua, in preterm gestation
Chan‐Wook Park, Sun Min Kim, Joong Shin Park, Jong Kwan Jun, Bo Hyun Yoon
SJR Q2The Journal of Maternal-Fetal & Neonatal Medicine

Intraamniotic inflammation was more frequent and intense in patients with inflammation restricted to chorio-decidua than in those without placental inflammation. However, fetal and maternal inflammatory responses were similar between these two groups.

EpidemiologyMedicine
7
Article|28 citations·2013
A Fetal and an Intra-Amniotic Inflammatory Response Is More Severe in Preterm Labor than in Preterm PROM in the Context of Funisitis: Unexpected Observation in Human Gestations
Chan‐Wook Park, Bo Hyun Yoon, Joong Shin Park, Jong Kwan Jun
SJR Q1PLoS ONEOA

A fetal and an IA inflammatory-response is more severe in PTL than in preterm-PROM in the context of funisitis, despite less common IA infection. This unexpected observation may indicate the fundamental difference in the pathogenesis between PTL and preterm-PROM.

EpidemiologyMedicine
8
Article|27 citations·2013
The frequency and clinical significance of intra-amniotic inflammation defined as an elevated amniotic fluid matrix metalloproteinase-8 in patients with preterm labor and low amniotic fluid white blood cell counts
Chan‐Wook Park, Bo Hyun Yoon, Sun Min Kim, Joong Shin Park, Jong Kwan Jun
SJR Q2Obstetrics & Gynecology ScienceOA

OBJECTIVE: To determine the frequency and clinical significance of intra-amniotic inflammation (IAI) defined as an elevated amniotic fluid (AF) matrix metalloproteinase-8 (MMP-8) concentration in patients with preterm labor and intact membranes (PTL) and low AF white blood cell (WBC) counts. METHODS: Adverse pregnancy outcomes were compared according to the presence or absence of IAI in 220 singleton gestations who underwent amniocentesis due to PTL (gestational age<35.7 weeks) and had low AF WB

EpidemiologyMedicine
9
Article|26 citations·2013
An elevated maternal serum C-reactive protein in the context of intra-amniotic inflammation is an indicator that the development of amnionitis, an intense fetal and AF inflammatory response are likely in patients with preterm labor: clinical implications
Chan‐Wook Park, Bo Hyun Yoon, Joong Shin Park, Jong Kwan Jun
SJR Q2The Journal of Maternal-Fetal & Neonatal Medicine

An elevated maternal serum CRP concentration in the context of IAI is an indicator that the development of amnionitis, an intense fetal and AF inflammatory response are likely in patients with PTL.

EpidemiologyMedicine
10
Article|21 citations·2015
Mild to Moderate, but Not Minimal or Severe, Acute Histologic Chorioamnionitis or Intra-Amniotic Inflammation Is Associated with a Decrease in Respiratory Distress Syndrome of Preterm Newborns without Fetal Growth Restriction
Chan‐Wook Park, Joong Shin Park, Jong Kwan Jun, Bo Hyun Yoon
SJR Q1Neonatology

BACKGROUND: Acute histologic chorioamnionitis (acute-HCA) is known to be associated with a decreased risk of respiratory distress syndrome (RDS) in newborns. However, there is no information about whether the severity of acute-HCA or intra-amniotic inflammation (IAI) is associated with the development of RDS. OBJECTIVES: To assess the relationship between the severity of acute-HCA or IAI and the development of RDS in preterm newborns due to preterm labor and intact membranes (PTL) or preterm pre

EpidemiologyMedicine
11
Article|21 citations·2009
제18대 국회의원 총선거에서 한국유권자들의 분할투표 행태에 관한 분석
박찬욱, 홍지연

2008년 제18대 총선에서 한국 유권자들은 2표병립제를 통해 지역구선거와 비례대표선거에서 각각 한 표씩 두 표를 행사하였다. 이 논문은 선거 후 실시한 두 가지 설문조사의 자료를 사용하여 이러한 2표병립제에서 일어나는 분할투표 현상에 대해 분석한다. 2표병립제 하에서 분할투표란 유권자가 지역구선거에서 선택한 후보의 정당이 비례대표선거에서 선택한 정당과 일치하지 않는 경우를 의미한다. 2008년 총선에서는 전체투표자의 25~35% 수준이 분할투표를 한 것으로 추정된다. 전체 분할투표에서 가장 많은 비중을 차지한 것은 지역구선거에서 한나라당, 비례대표선거에서 친박연대를 선택한 사례였다. 한나라당/친박연대의 분할투표는 전형적인 전략적 분할투표에 속한다. 이들 중 절반은 사표방지심리에 의해, 나머지 절반은 연합보장 의도에 따라 분할투표를 한 경우라고 해석된다. 한편, 통합민주당/한나라당 분할투표는 정책균형 분할투표로 간주될 수 있을 것이다. 이들 대부분은 진보정당에 의해 견제 받지 않는

12
Article|21 citations·2013
사회통합의 방향: 한국정치의 과제
박찬욱
저스티스

민주화 이후 한국 사회에서는 지역갈등, 계층갈등, 이념갈등, 세대갈등 등이 동시다발적으로 전개되고 있다. 사회가 당면한 갈등을 증폭하는 분열의 정치보다는 갈등이 구조적으로 심화되기 이전에 상이한 이익과 의사를 타협⋅조정하는 통합의 정치가 좋은 정치이다. 통합의 정치는 사회갈등을 제도적 통로에 의해 수렴하고 이성적인 정책논쟁을 거쳐 해소하여 국가와 사회를 발전시킨다. 한국 정치는 1987년 민주화 이후 발전 도상에 있다. 특히 선거과정과 정치적 다원주의 차원에서 국제적으로 인정되는 수준에 도달했다. 그러나 통합의 정치를 실현하려면 표현과 언론의 자유 등 시민 자유, 정부의 투명성과 효율성, 시민의 정치참여와 민주적 정치문화의 차원에서 개선할 여지가 많다. 한국 민주정치의 부단한 진화를 위해 개혁의 노력을 멈출 수 없다. 절차적 민주주의의 지속적인 발전을 기하는 동시에 민주주의 질을 고양하여 정치의 사회통합력을 신장해야 한다. 그러한 방향으로 권력분산, 그리고 견제와 균형을 보장하기 위

13
Article|16 citations·2003
김대중 대통령 시기 국회와 행정부의 관계
박찬욱, 박홍민

본 논문에서는 김대중대통령 시기 국회와 행정부의 관계를 살펴보았다. 먼저 국회의 활동을 중심으로 하여 분석했다. 이를 통해 여소야대의 경우보다 여대야소의 경우가, 의원들의 양극화 정도가 약한 경우보다 강한 경우가, 그리고 시민사회의 활동이 활발한 경우가, 국회의 대 행정부 활동을 증가시킨다는 것을 밝혔다. 다음으로 행정부의 활동을 중심으로 하여 분석했다. 이를 통해 대통령의 지지도가 높을수록, 대통령 비서진이 주도권을 가지기보다는 지원의 수준에 머무를수록, 그리고 대통령의 정당에 대한 통제가 강할수록, 행정부의 대 국회 활동을 증가시킨다는 것을 밝혔다.

14
Article|13 citations·2013
Which is more important for the intensity of intra-amniotic inflammation between total grade or involved anatomical region in preterm gestations with acute histologic chorioamnionitis?
Chan‐Wook Park, Bo Hyun Yoon, Sun Min Kim, Joong Shin Park, Jong Kwan Jun
SJR Q2Obstetrics & Gynecology ScienceOA

OBJECTIVE: There is no data on which is more important for the intensity of intra-amniotic inflammation (IAI) between total grade or involved anatomical region in acute histologic chorioamnionitis (acute-HCA) of preterm-gestations. The objective of current study is to examine this issue. METHODS: The intensity of IAI was measured by amniotic fluid (AF) white blood cell (WBC) count and matrix metalloproteinase-8 (MMP-8) concentration in 225 singleton preterm-gestations (<36 weeks) who had acute-H

EpidemiologyMedicine
15
Article|12 citations·2021
Neutrophil to Lymphocyte Ratio in Maternal Blood: A Clue to Suspect Amnionitis
Joon‐Hyung Lee, Chan‐Wook Park, Kyung Chul Moon, Joong Shin Park, Jong‐Kwan Jun
SJR Q1Journal of Clinical MedicineOA

There is no information about whether maternal neutrophil to lymphocyte ratios (NLRs) progressively increase with respect to the progression of acute histologic chorioamnionitis (acute-HCA) and increased maternal NLR is a risk factor for amnionitis, known as advanced acute-HCA, in pregnant women at risk for spontaneous preterm birth (PTB). The objective of the current study is to examine this issue. The study population included 132 singleton PTB (&lt;34 weeks) due to either preterm labor or pre

EpidemiologyMedicine

Research Areas

EpidemiologyObstetrics and GynecologyPediatrics, Perinatology and Child HealthPulmonary and Respiratory MedicineSurgeryMarketing

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