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Chang Kyu Sung

Seoul National University · Medicine

About the Lab

Professor Chang Kyu Sung's research lab specializes in medical imaging and interventional radiology, focusing on improving diagnostic accuracy in renal diseases through advanced imaging techniques such as CT and Doppler ultrasound. The lab investigates vascular hemodynamics, tumor characterization (particularly angiomyolipoma and renal cell carcinoma), and image-guided ablation therapies like irreversible electroporation. It also explores multimodal molecular imaging agents for stem cell tracking, combining MRI and optical imaging for enhanced visualization. The lab emphasizes the clinical translation of imaging biomarkers and computational models to optimize patient outcomes.

medical imagingrenal tumorsDoppler ultrasoundimage-guided ablationmolecular imaging

Research Overview

Papers
66
Total Citations
480
Papers (5y)
15
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
15total
2020
2023
2024
2025
2026
Citations per year (5y)
26total
20202023202420252026

Selected Papers

15
1
Article|51 citations·2015
Angiomyolipoma with minimal fat: differentiation of morphological and enhancement features from renal cell carcinoma at CT imaging
Chang Kyu Sung, See Hyung Kim, Sungmin Woo, Min Hoan Moon, Sang Youn Kim, Seung Hyup Kim, Jeong Yeon Cho
SJR Q3Acta Radiologica

BACKGROUND: Angiomyolipoma (AML) with minimal fat may mimic renal cell carcinoma (RCC) and is difficult to distinguish from RCC with imaging studies alone. Precise diagnostic strategies have been explored to discern AML with minimal fat from RCC. PURPOSE: To compare the morphological and enhancement features of AML with minimal fat with those of size-matched RCC on computed tomography (CT). MATERIAL AND METHODS: Our study included 143 pathologically proved renal tumors (29 AML with minimal fat:

PhysiologyMedicine
2
Article|34 citations·2009
Dual-Modal Nanoprobes for Imaging of Mesenchymal Stem Cell Transplant by MRI and Fluorescence Imaging
Chang Kyu Sung, Kyung Ah Hong, Shunmei Lin, Yuwon Lee, Jinmyung Cha, Jin‐Kyu Lee, Cheol Pyo Hong, Bong Soo Han, Sung Il Jung, Seung Hyup Kim, Kang Sup Yoon
SJR Q1Korean Journal of RadiologyOA

MNP@SiO(2)(RITC)-PEG can be a useful contrast agent for stem cell imaging, which is suitable for a bimodal detection by MRI and optical imaging.

Molecular BiologyBiochemistry, Genetics and Molecular Biology
3
Article|20 citations·2016
Evaluation of factors influencing arterial Doppler waveforms in an in vitro flow phantom
Chang Kyu Sung, Kyoung Ho Lee, Seung Hyup Kim
SJR Q1ULTRASONOGRAPHYOA

Resistance and compliance can alter the Doppler waveforms independently. The pulse rate is an extrinsic factor that also influences the RI. The compliance and distal resistance, as well as proximal resistance, influence the pulsus tardus and parvus phenomenon.

Pulmonary and Respiratory MedicineMedicine
4
Article|18 citations·2019
Physicochemical factors that affect electroporation of lung cancer and normal cell lines
Hong Bae Kim, Seho Lee, Yiming Shen, Pan Dong Ryu, Yunmi Lee, Jong Hoon Chung, Chang Kyu Sung, Ku Youn Baik
SJR Q2Biochemical and Biophysical Research Communications
BiotechnologyBiochemistry, Genetics and Molecular Biology
5
Article|16 citations·2020
Effects of Actin Cytoskeleton Disruption on Electroporation In Vitro
Hong Bae Kim, Seho Lee, Jong Hoon Chung, Seong Nam Kim, Chang Kyu Sung, Ku Youn Baik
SJR Q2Applied Biochemistry and Biotechnology
BiotechnologyBiochemistry, Genetics and Molecular Biology
6
Article|14 citations·2016
Histological and Mathematical Analysis of the Irreversibly Electroporated Liver Tissue
Chang Kyu Sung, Hong Bae Kim, Jong Hyun Jung, Ku Youn Baik, Kee Wook Moon, Hyung-Sik Kim, Jeong‐Han Yi, Jong Hoon Chung
SJR Q2Technology in Cancer Research & TreatmentOA

Irreversible electroporation has clinically been used to treat various types of cancer. A plan on how to apply irreversible electroporation before practicing is very important to increase the ablation area and reduce the side effects. Several electrical models have been developed to predict the ablation area with applied electric energy. In this experiment, the static relationship between applied electric energy and ablated area was mathematically and experimentally investigated at 10 hours afte

BiotechnologyBiochemistry, Genetics and Molecular Biology
7
Article|9 citations·2006
Urine Attenuation Ratio: A New CT Indicator of Renal Artery Stenosis
Chang Kyu Sung, Jin Wook Chung, Seung Hyup Kim, Jae Hyung Park
SJR Q1American Journal of Roentgenology

The urine CT attenuation ratio is a simple and reliable indicator with which to detect and lateralize significant RAS and is a useful adjunct to helical CTA.

Pulmonary and Respiratory MedicineMedicine
8
Article|3 citations·2015
Factors influencing the renal arterial Doppler waveform: a simulation study using an electrical circuit model (secondary publication)
Chang Kyu Sung, Bong Soo Han, Seung Hyup Kim
SJR Q1ULTRASONOGRAPHYOA

This simulation study using an electrical circuit model led to a better understanding of the renal arterial Doppler waveform and the RI, which may be useful for interpreting Doppler findings in various clinical settings.

Pulmonary and Respiratory MedicineMedicine
9
Article|3 citations·2008
Grayscale and Doppler Ultrasonographic Findings Reflecting Disease Severity in Autosomal Dominant Polycystic Kidney Disease
Chang Kyu Sung, Seung Hyup Kim, Curie Ahn
SJR Q3Journal of Medical UltrasoundOA

The purpose of this study was to identify the ultrasonographic findings that reflected disease severity in patients with autosomal dominant polycystic kidney disease (ADPKD). In 72 patients with ADPKD, resistive indices (RIs) and the severity of ultrasonographic morphologic abnormalities, such as renal severity index (RSI), modified RSI and the sum of bilateral renal size, were measured and correlated with clinical and laboratory findings including the presence of hypertension and serum creatini

GeneticsBiochemistry, Genetics and Molecular Biology
10
Article|2 citations·2016
Standard vs. reduced-radiation-dose CT in the tracing of the ureter
Chang Kyu Sung, Min Hoan Moon, Hwancheol Son, Sohee Oh, Myoung Seok Lee, Hyunsik Woo
SJR Q1Abdominal Radiology
Pulmonary and Respiratory MedicineMedicine
11
Book Chapter|2 citations·2016
Retroperitoneal Tumors
Chang Kyu Sung, Bohyun Kim, Kyung Chul Moon, Ja Hyeon Ku, Seung Beom Ha
Pulmonary and Respiratory MedicineMedicine
12
Article|1 citations·2023
Robust Doppler compensation for low frequency underwater communications
Chang Kyu Sung, Patrick Cooper, Daniel La Mela, Tim Cain
SJR Q1The Journal of the Acoustical Society of America

Impairment caused by Doppler frequency shift and harsh channel condition distinguish underwater acoustic communications from radio communications. Slow speed of acoustic waves produces relatively high Doppler shift and result in expansion or compression in time samples, which is known as Doppler scaling. In particular, the Doppler scaling causes significant carrier frequency offset (CFO) in orthogonal frequency division modulation (OFDM). To compensate the CFO, it is essential to resample signal

Ocean EngineeringEngineering
13
Article|1 citations·2023
Histological Response to 5 kHz Irreversible Electroporation in a Porcine Liver Model
Hong Bae Kim, Ku Youn Baik, Chang Kyu Sung
SJR Q2Technology in Cancer Research & TreatmentOA

Unlike necrosis by thermal ablation, irreversible electroporation (IRE) is known to induce apoptosis by disrupting plasma membrane integrity with electric pulses while preserving the structure of blood vessels and bile ducts in liver tissue without a heat sink effect. This study aimed to investigate thermal damage and histopathological effects in the porcine liver by high-frequency electric pulses (5 kHz) which is much higher than the widely used 1 Hz. The electric field and thermal distribution

BiotechnologyBiochemistry, Genetics and Molecular Biology
14
Article|1 citations·2025
Use of Mitochondrial Delayed Luminescence Measurements From Brain Tissue to Optimize Photobiomodulation Prarameters in Alzheimer's Disease Mice
Hong Bae Kim, Chang Kyu Sung
SJR Q2Journal of BiophotonicsOA

ABSTRACT The therapeutic potential of photobiomodulation (PBM) for Alzheimer's disease (AD) was evaluated by examining β‐amyloid accumulation, microglial activation, and memory function. Mitochondrial delayed luminescence (m‐DL), an indirect mitochondrial marker, was measured by irradiating 2 J/cm 2 of 808 nm near‐infrared light to the exposed brain surface of anesthetized 5XFAD mice. Based on m‐DL findings, behavioral PBM was applied transcranially to the intact scalp using the same fluence at

Radiology, Nuclear Medicine and ImagingMedicine
15
Book Chapter|1 citations·2012
Introduction
Chang Kyu Sung, Jung Suk Sim
Reproductive MedicineMedicine

Research Areas

Pulmonary and Respiratory MedicineRadiology, Nuclear Medicine and ImagingSurgeryReproductive MedicineBiotechnologyUrology

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