Chang Sin Kim
Yonsei University · Medicine
About the Lab
Professor Chang Sin Kim's research lab specializes in pediatric and congenital cardiovascular diseases, with a focus on advanced echocardiographic imaging, particularly speckle tracking echocardiography, to assess myocardial mechanics in children. The lab investigates the hemodynamic changes associated with aging and disease states such as aortic regurgitation, ventricular septal defects, and rare arrhythmias like idiopathic ventricular fibrillation and early repolarization syndrome. They also explore interventional and surgical outcomes in high-risk pediatric and young adult patients, including those with complex conditions like Behçet syndrome and pulmonary interstitial emphysema in extremely low birth weight infants. Their work bridges diagnostic imaging, interventional cardiology, and clinical outcomes in congenital and inherited heart diseases.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
12BACKGROUND: The speckle tracking echocardiography can benefit to assess the regional myocardial deformations. Although, previous reports suggested no significant change in left ventricular (LV) torsion with aging, there are certain differences in LV rotation at the base and apex. The purpose of this study was to evaluate the change and relationship of LV rotation for torsion with aging in children. METHODS: Forty healthy children were recruited and divided into two groups of twenty based on whet
The pulmonary interstitial emphysema (PIE) is a life-threatening illness in premature infants with mechanical ventilation. While most are managed conservatively, decompression would be necessary. Here, we report the first case of PIE treated by percutaneouscatheter insertion in an extremely low birth weight (ELBW) infant in Korea. The patient, born with 660 g in 23+2 weeks of gestation,showed PIE in left lower lung on postnatal day 12. Percutaneous catheter insertion was performed on postnatal d
Background: The speckle tracking echocardiography can benefit to assess the regional myocardial deformations. Although,previous reports suggested no significant change in left ventricular (LV) torsion with aging, there are certain differences in LV rotationat the base and apex. The purpose of this study was to evaluate the change and relationship of LV rotation for torsion withaging in children. Methods: Forty healthy children were recruited and divided into two groups of twenty based on whether
Aortic regurgitation (AR) in children is usually caused by congenital valve anomalies, and Behçet syndrome (BS) can be suspected in cases of isolated AR. Patients with BS undergoing aortic valve surgery due to aortic valve invasion have a high risk of complications, such as leakage around the valve and dehiscence. Cardiovascular involvement occurs in 7%-46% of adult patients with BS and is the main cause of mortality; however, its prevalence is unclear and rare in children. A 12-year-old boy was
A ventricular septal defect (VSD) is the most prevalent congenital heart disease.Some patients who were watched without surgery when they were young need surgery as they age.The surgical approach is the standard treatment and suitable for young age, but it can be complex in these patients of advanced age with multiple risk factors including cardiometabolic syndrome.We present two cases of transcatheter VSD closure that were successful in patients in their 60s who had a variety of comorbidities.F
BACKGROUND Idiopathic ventricular fibrillation (IVF) and early repolarization syndrome (ERS) are rare but potentially life-threatening arrhythmias. Their clinical distinction is often challenging and prognostic factors remain unclear, particularly in adolescents. OBJECTIVE This study compared clinical outcomes and electrocardiographic characteristics of adolescents with IVF and ERS to identify disease-specific prognostic factors. METHODS Patients diagnosed with IVF or ERS between 2000 and 2022 w
Abstract Background Patients with Fontan circulation experience significant morbidity from supraventricular tachyarrhythmias (SVTs). However, the electrophysiological features of SVT and the efficacy and safety of catheter ablation in patients with Fontan circulation are poorly understood. This study aimed to elucidate the electrophysiological features of SVT and evaluate the efficacy and safety of catheter ablation in patients with Fontan circulation. Methods Forty-nine patients (age, 29.2±10.0
Fontan patients with long-term follow-up showed a progressive decline in ventricular and AVV function. Dominant RV, TV and common AVV were prognostic factors for predicting AVV failure. Further studies are warranted to explore and validate these findings.
BACKGROUND: Patients with congenital or acquired right ventricular outflow tract dysfunction frequently require pulmonary valve replacement and are exposed to repeated surgical interventions due to prosthetic valve degeneration. The PULSTA self-expanding transcatheter pulmonary valve was designed to address a broad spectrum of native and surgically repaired right ventricular outflow tract anatomies. This study reports the midterm safety, hemodynamic performance, and durability outcomes of the pr
Research Areas
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