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Dae Eun Ko

Yonsei University · Medicine

About the Lab

Professor Dae Eun Ko's research lab focuses on translational biomedical research, particularly in the fields of cancer biology, surgical outcomes, and critical care medicine. The lab investigates molecular mechanisms underlying colorectal cancer through microRNA regulation and epigenetic modifications, while also exploring prognostic biomarkers such as inflammatory and nutritional markers in vascular and renal surgery. A key direction involves identifying preoperative laboratory parameters that predict postoperative complications and mortality in high-risk surgical populations, including patients with abdominal aortic aneurysms and end-stage renal disease. The lab integrates clinical data with molecular and biochemical analyses to improve patient risk stratification and outcomes.

colorectal cancersurgical outcomesbiomarkersinflammatory markerskidney transplantation

Research Overview

Papers
10
Total Citations
71
Papers (5y)
8
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
8total
2019
2020
2021
2022
2023
Citations per year (5y)
50total
20192020202120222023

Selected Papers

10
1
Article|20 citations·2019
Association between TP53 genetic polymorphisms and the methylation and expression of miR‑34a, 34b/c in colorectal cancer tissues
Hak Hoon Jun, KyuBum Kwack, Keun Lee, Jung Oh Kim, Han Park, Chang Hwan Ryu, Jeong Woo Lee, Da Eun Ko, Jong Hwan Kim, Nam Keun Kim
SJR Q3Oncology LettersOA

Colorectal cancer (CRC) is one of the most common types of cancers, as evidenced by the >1.2 million patient diagnoses and 600,000 mortalities globally each year. Recently, the microRNA (miR/miRNA)-34 miRNA precursor family was revealed to participate in the tumor protein (TP)-53 pathway, which is frequently involved in CRC. Furthermore, the expression of miR-34 is reportedly regulated by DNA methylation. Accordingly, the present study investigated the correlation between the methylation status

Cancer ResearchBiochemistry, Genetics and Molecular Biology
2
Article|20 citations·2018
Association study of the three functional polymorphisms (TAS2R46G>A, OR4C16G>A, and OR4X1A>T) with recurrent pregnancy loss
Chang Soo Ryu, Jung Hyun Sakong, Eun Hee Ahn, Jung Oh Kim, Da Eun Ko, Ji Hyang Kim, Woo Sik Lee, Nam Keun Kim
SJR Q3Genes & Genomics
HematologyMedicine
3
Article|14 citations·2020
Combined time bound optimization of control, communication, and data processing for FSO‐based 6G UAV aerial networks
서승우, 고다은, 정종문
https://doi.org/10.4218/etrij.2020-0210

Because of the rapid increase of mobile traffic, flexible broadband supportive unmanned aerial vehicle (UAV)‐based 6G mobile networks using free space optical (FSO) links have been recently proposed. Considering the advancements made in UAVs, big data processing, and artificial intelligence precision control technologies, the formation of an additional wireless network based on UAV aerial platforms to assist the existing fixed base stations of the mobile radio access network is considered a high

4
Article|11 citations·2021
Preoperative Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume as Predictors of 1-Year Mortality in Patients Undergoing an Open Repair of Abdominal Aortic Aneurysms: A Retrospective Study
Da Eun Ko, Hei Jin Yoon, Sang Beom Nam, Suk‐Won Song, Gisong Lee, Sung Yeon Ham
SJR Q1Journal of Clinical MedicineOA

Objectives: To investigate if preoperative neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), or mean platelet volume (MPV) could be used to predict 1-year mortality in patients undergoing open abdominal aortic aneurysm (AAA) repair. Methods: We retrospectively reviewed 382 patients who underwent open AAA repair between January 2008 and July 2019. We divided the patients into two groups based on 1-year mortality and compared the preoperative NLR, PLR, and MPV. The patients

OncologyMedicine
5
Article|2 citations·2023
Postoperative Hypoalbuminemia as a Predictor of Acute Kidney Injury After Open Repair of Ruptured Abdominal Aortic Aneurysm
Hei Jin Yoon, Tae‐Hoon Kim, Da Eun Ko, Jong Wook Song, Nar Hyun Min, Sung Yeon Ham
SJR Q1World Journal of Surgery

BACKGROUND: Perioperative hypoalbuminemia has a prognostic effect on mortality and morbidity in various cohorts. Patients undergoing open repair of ruptured abdominal aortic aneurysms (rAAA) are at a high risk of hypoalbuminemia due to bleeding and underlying diseases. Hence, this study aimed to investigate the predictive value of immediate postoperative hypoalbuminemia for the risk for acute kidney injury (AKI) in patients undergoing open rAAA repair. METHODS: We retrospectively reviewed 143 pa

Critical Care and Intensive Care MedicineMedicine
6
Article|2 citations·2019
Hepatic failure caused by acute fatty liver of pregnancy treated by orthotopic liver transplantation - A case report -
Yun-Sic Bang, Da Eun Ko, Sunyoung Lee, Seunghoon Lee, Chunghyun Park
SJR Q2Anesthesia and Pain MedicineOA

The dangerous conditions of pregnancy with the signs of liver failure include hyperemesis gravidarum, cholestatic syndromes of pregnancy, HELLP syndrome (hemolysis, elevated liver enzymes, low platelets), and the most rarely observed, acute fatty liver of pregnancy (AFLP) It is a rare complication of pregnancy but is potentially fatal for both mother and fetus. AFLP may begin innocuously with mild symptoms and liver-enzyme abnormalities, but, if left untreated, can progress to jaundice, liver fa

EpidemiologyMedicine
7
Article|1 citations·2022
Prognostic value of preoperative serum alkaline phosphatase for predicting 3-year mortality in patients undergoing kidney transplantation: A retrospective study
Hei Jin Yoon, Da Eun Ko, Sang Beom Nam, Young Song, Byung Hwan Yun, Sung Yeon Ham
SJR Q1PLoS ONEOA

Serum alkaline phosphatase (ALP) levels are related to high-turnover bone disease and reflect vascular calcification and inflammation. ALP has been reported to have a prognostic impact in various cohorts including chronic kidney disease. This study investigated whether preoperative serum ALP level could be used for predicting mortality in patients undergoing kidney transplantation. We retrospectively reviewed 1,718 patients who underwent kidney transplantation between November 2005 and June 2017

NephrologyMedicine
8
Article|1 citations·2017
Brugada Syndrome Patient Undertaken Brachial Plexus Block
Yun-Sic Bang, Seon-Yi Lee, Da Eun Ko, Junbeom Park, So Woon Ahn, Chunghyun Park
The Ewha Medical JournalOA

Brugada syndrome is an arrhythmic syndrome characterized by right bundle branch block, ST segment elevation in the precordial lead (V1-V3), and sudden death caused by ventricular fibrillation, which is not effectively prevented by anti-arrhythmic drug therapy. We are reporting a 30-year-old male patient with Brugada syndrome who got an exploratory laparotomy and a tenorrhaphy due to stab wound which was managed with general anesthesia and brachial plexus block without any complications.

Cardiology and Cardiovascular MedicineMedicine
9
Article|0 citations·2020
Juvenile Xanthogranuloma of the Tongue
Da Eun Ko, Jung‐Hoon Yoon
The Korean Journal of Oral and Maxillofacial Pathology
PhysiologyMedicine
10
Preprint|0 citations·2021
Prognostic value of preoperative serum alkaline phosphatase for predicting 3-year mortality in patients undergoing kidney transplantation: A retrospective study
Hei Jin Yoon, Da Eun Ko, Sang Beom Nam, Young Rim Song, Byung Hwan Yun, Sung Yeon Ham
Research SquareOA

Abstract Serum alkaline phosphatase (ALP) levels are related to high-turnover bone disease and reflect vascular calcification and inflammation. ALP has been reported to have a prognostic impact in various cohorts including chronic kidney disease. This study investigated whether preoperative serum ALP level could be used for predicting mortality in patients undergoing kidney transplantation. We retrospectively reviewed 1,718 patients who underwent kidney transplantation between November 2005 and

NephrologyMedicine

Research Areas

NephrologyCancer ResearchHematologyOncologyCritical Care and Intensive Care MedicineEpidemiology

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