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Dae Sik Yang

Korea University · Medicine

About the Lab

Professor Dae Sik Yang's research lab specializes in clinical and translational radiation oncology, with a focus on improving radiotherapy outcomes for urological and gynecological cancers, including upper tract urothelial carcinoma and early-stage cervical cancer. The lab investigates advanced radiotherapy techniques such as stereotactic body radiation therapy (SBRT) and intensity-modulated radiotherapy (IABR), emphasizing treatment efficacy, local control, and complication management. Additionally, the lab contributes to the development and validation of predictive nomograms for survival outcomes, integrating clinical and imaging data to personalize treatment strategies. The research also extends to neuro-ophthalmological mechanisms, particularly the neural control of optokinetic nystagmus in animal models, highlighting interdisciplinary interests in physiological systems and their clinical implications.

radiation oncologySBRTnomogram validationcancer radiotherapyoptokinetic nystagmus

Research Overview

Papers
163
Total Citations
1,127
Papers (5y)
18
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
18total
2021
2022
2023
2024
2025
Citations per year (5y)
54total
20212022202320242025

Selected Papers

15
1
Review|44 citations·2019
Is stereotactic body radiotherapy for ultra-central lung tumor a feasible option? A systemic review and meta-analysis
Chai Hong Rim, Young Kim, Chul Yong Kim, Won Sup Yoon, Dae Sik Yang
SJR Q2International Journal of Radiation Biology

SBRT for UC tumors confers efficient LC, although the risk of complications was not negligible. Control of possible risk factors of hemorrhage and dose optimization through further studies are warranted.

Pulmonary and Respiratory MedicineMedicine
2
Article|35 citations·1996
ImprovedR-space resolution of EXAFS spectra using combined regularization methods and nonlinear least-squares fitting
Dae Sik Yang, Grant Bunker
Physical review. B, Condensed matter

A number of methods have proven to be useful for extended x-ray-absorption fine-structure data analysis of disordered systems. Regularization methods, which describe the radial distribution function nonparametrically, have the advantages of eliminating bias caused by modeling the distribution with a specific functional form, properly including spherical wave effects, and allowing the imposition of physical constraints in a systematic way. In this work we find empirically that the regularization

RadiationPhysics and Astronomy
3
Article|30 citations·2013
Set-up uncertainty during breast radiotherapy
Dae Sik Yang, Won Sup Yoon, Se Young Chung, J.A. Lee, Suk Lee, Y.J. Park, Chul Yong Kim, Gil Soo Son
SJR Q2Strahlentherapie und Onkologie
Cancer ResearchBiochemistry, Genetics and Molecular Biology
4
Review|22 citations·2010
Association of a vascular endothelial growth factor gene 936 C/T polymorphism with breast cancer risk: a meta-analysis
Dae Sik Yang, Kyong Hwa Park, Ok Hee Woo, Sang Uk Woo, Aeree Kim, Eun Sook Lee, Jae-Bok Lee, Yeul Hong Kim, Jun Suk Kim, Jae Hong Seo
SJR Q1Breast Cancer Research and Treatment
Molecular BiologyBiochemistry, Genetics and Molecular Biology
5
Article|15 citations·2012
Risk factors related to interfractional variation in whole pelvic irradiation for locally advanced pelvic malignancies
Won Sup Yoon, Dae Sik Yang, J.A. Lee, Suk Lee, Y.J. Park, Chul Yong Kim
SJR Q2Strahlentherapie und Onkologie
RadiationPhysics and Astronomy
6
Article|12 citations·2014
The effectiveness of gadolinium MRI to improve target delineation for radiotherapy in hepatocellular carcinoma: A comparative study of rigid image registration techniques
Dae Sik Yang, Won Sup Yoon, J.A. Lee, N.K. Lee, S. Lee, Chul Yong Kim, Hyung Joon Yim, Seung-Hoon Lee, Hwan Hoon Chung, Salud Lawrence H.
SJR Q1Physica Medica
HepatologyMedicine
7
Review|11 citations·2021
Salvage External Beam Radiotherapy after Incomplete Transarterial Chemoembolization for Hepatocellular Carcinoma: A Meta-Analysis and Systematic Review
Dae Sik Yang, Sunmin Park, Chai Hong Rim, Won Byong Yoon, In‐Soo Shin, Han Ah Lee
SJR Q2MedicinaOA

Background and objective: Although transarterial chemoembolization (TACE) has been the commonest local modality for hepatocellular carcinoma (HCC), incomplete repsonse occurs especially for tumors with a large size or difficult tumor accessment. The present meta-analysis assessed the efficacy and feasibility of external beam radiotherapy (EBRT) as a salvage modality after incomplete TACE. Materials and Methods: We systematically searched the PubMed, Embase, Medline, and Cochrane databases. The p

HepatologyMedicine
8
Article|10 citations·2013
Interfractional variability in intensity-modulated radiotherapy of prostate cancer with or without thermoplastic pelvic immobilization
J.A. Lee, Chul Yong Kim, Y.J. Park, Won Sup Yoon, N.K. Lee, Dae Sik Yang
SJR Q2Strahlentherapie und Onkologie
RadiationPhysics and Astronomy
9
Article|9 citations·2019
Long-term outcomes of immediate autologous breast reconstruction after definite adjuvant therapy in intermediate and locally advanced breast cancer
Won Sup Yoon, Chai Hong Rim, Dae Sik Yang, Jung Ae Lee, Gil Soo Son, Young Woo Chang, Sang Uk Woo, Deok‐Woo Kim, Eun‐Sang Dhong
Annals of Translational MedicineOA

IABR showed feasible oncologic outcomes in 5-year follow-up. Adjuvant radiotherapy had little effect on quality of reconstruction. However, IABR in advanced stage should be cautiously applied considering expected survival and minor problems after IABR.

SurgeryMedicine
10
Article|8 citations·2012
Whole breast irradiation for small-sized breasts after conserving surgery: is the field-in-field technique optimal?
Dae Sik Yang, Jung Ae Lee, Won Sup Yoon, Se Young Chung, Suk Lee, Chul Yong Kim, Young Je Park, Gil Soo Son
SJR Q1Breast Cancer
RadiationPhysics and Astronomy
11
Review|7 citations·2009
Association of a progesterone receptor gene +331 G/A polymorphism with breast cancer risk: a meta-analysis
Dae Sik Yang, Hwa Jung Sung, Ok Hee Woo, Kyong Hwa Park, Sang Uk Woo, Aeree Kim, Eun Sook Lee, Jae-Bok Lee, Yeul Hong Kim, Jun Suk Kim, Jae Hong Seo
Cancer Genetics and Cytogenetics
GeneticsBiochemistry, Genetics and Molecular Biology
12
Article|5 citations·2017
Validation of Nomograms for Survival and Metastases after Hysterectomy and Adjuvant Therapy in Uterine Cervical Cancer with Risk Factors
Won Sup Yoon, Dae Sik Yang, Jung Ae Lee, Nam Kwon Lee, Young Je Park, Chul Yong Kim, Nak Woo Lee, Jin Hwa Hong, Jae Kwan Lee, Jae Yun Song
SJR Q2BioMed Research InternationalOA

Background . Three nomogram models for early stage uterine cervical cancer have been developed (KROG 13-03 for overall survival [OS], SNUH/AMC for disease-free survival [DFS], and KROG 12-08 for distant metastases-free survival [DMFS]) after radical hysterectomy (RH) and pelvic lymph node dissection (PLND). This study aimed to validate these models using our cohort with adjuvant radiotherapy. Methods . According to the eligibility criteria of nomogram studies, patients were enrolled in Group A (

Obstetrics and GynecologyMedicine
13
Article|4 citations·1989
[The result of extended thymectomy in patients with myasthenia gravis of pure ocular type].
Dae Sik Yang, Keiichi Nakahara, Koichi Ohno, Junichiro Hashimoto, Hajime Maeda, S Miyoshi, Akihiko Matsumura, T Mizuta, A Akashi, Y Kawashima
PubMed

We studied postoperative status of 14 patients with myasthenia gravis of ocular type who underwent extended thymectomy. Nine patients were in remission, three improved, and two unchanged. No patient became worse and died. The remission rates at one, three, five, and ten years after operation were 50.0%, 58.3%, 60.0%, and 80.0%. The palliation rates at one, three, five, and ten years after operation were 64.3%, 75.0%, 80.0%, and 100%. The remission rate at one year after operation in patients of

NeurologyMedicine
14
Article|4 citations·2024
Preliminary Results of Developing Imaging Complexity Biomarkers for the Incidence of Severe Radiation Pneumonitis Following Radiotherapy in Non-Small Cell Lung Cancer Patients with Underlying Idiopathic Pulmonary Fibrosis
Jeongeun Hwang, Hakyoung Kim, Sun Myung Kim, Dae Sik Yang
SJR Q1LifeOA

Background: Idiopathic pulmonary fibrosis (IPF) has the potential to cause fatal pulmonary toxicity after radiotherapy and can increase the morbidity and mortality of non-small-cell lung cancer (NSCLC) patients. In this context, we aimed to develop imaging complexity biomarkers to predict the incidence of severe pulmonary toxicity in patients with NSCLC who have underlying IPF and are treated with radiotherapy. Methods: We retrospectively reviewed the medical records of 19 patients with NSCLC wh

Pulmonary and Respiratory MedicineMedicine
15
Article|4 citations·1998
[Optokinetic nystagmus (OKN) eye-movement mediated by direct and indirect pathways].
Dae Sik Yang, Sun Fc
PubMed

Nasal or temporal side of the cat's retina was stimulated with nasalward and temporalward moving patterns for investigating the neural control of the optokinetic nystagmus in the direct and indirect pathways of OKN. The experimental data demonstrated that there was a nasalward directional preference in cat's OKN system under both close loop and open loop conditions, and the nasalward OKN gain evoked by stimulation of nasal retina was much higher than that at temporal retina. This indicates that

Cellular and Molecular NeuroscienceNeuroscience

Research Areas

RadiationPulmonary and Respiratory MedicineOncologyRadiology, Nuclear Medicine and ImagingAerospace EngineeringObstetrics and Gynecology

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