Dong Gyu Jo
Sungkyunkwan University · Medicine
About the Lab
Professor Dong Gyu Jo's research lab specializes in regenerative medicine and nanomedicine, focusing on stem cell-derived extracellular vesicles (EVs) as cell-free therapeutics for degenerative diseases. The lab investigates the therapeutic potential of extracellular vesicles from adipose-derived stem cells in conditions such as osteoarthritis, osteoporosis, and neurodegenerative disorders like Alzheimer’s disease. Key research directions include EV isolation using tangential flow filtration, mechanistic studies of EV-mediated tissue repair, and the development of targeted drug delivery systems for rheumatoid arthritis. The lab also explores post-translational modifications, such as O-GlcNAcylation and lipid peroxidation products like HNE, in neurodegenerative pathology.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15ABSTRACT Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage that is the most common joint disease worldwide. Mesenchymal stem cells (MSCs) have been the most extensively explored for the treatment of OA. Recently, it has been demonstrated that MSC‐derived extracellular vesicles (EVs) may contribute to the potential mechanisms of MSC‐based therapies. In this study, we investigated the therapeutic potential of human adipose‐derived stem cells EVs (hASC‐EVs) in alleviating
Osteoporosis is one of the most common skeletal disorders caused by the imbalance between bone formation and resorption, resulting in quantitative loss of bone tissue. Since stem cell-derived extracellular vesicles (EVs) are growing attention as novel cell-free therapeutics that have advantages over parental stem cells, the therapeutic effects of EVs from adipose tissue-derived stem cells (ASC-EVs) on osteoporosis pathogenesis were investigated. ASC-EVs were isolated by a multi-filtration system
Increased O -GlcNAcylation can confer neuroprotective effects against necroptosis in the context of Alzheimer’s disease.
In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid-MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in RA.
The cause of elevated level of amyloid β-peptide (Aβ42) in common late-onset sporadic [Alzheimer's disease (AD)] has not been established. Here, we show that the membrane lipid peroxidation product 4-hydroxynonenal (HNE) is associated with amyloid and neurodegenerative pathologies in AD and that it enhances γ-secretase activity and Aβ42 production in neurons. The γ-secretase substrate receptor, nicastrin, was found to be modified by HNE in cultured neurons and in brain specimens from patients wi
Stem cell-derived extracellular vesicles (EVs) offer alternative approaches to stem cell-based therapy for regenerative medicine. In this study, stem cell EVs derived during differentiation are developed to use as cell-free therapeutic systems by inducing tissue-specific differentiation. EVs are isolated from human adipose-derived stem cells (HASCs) during white and beige adipogenic differentiation (D-EV and BD-EV, respectively) via tangential flow filtration. D-EV and BD-EV can successfully dif
Research Areas
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