Dong-In Oh

We report the development of a new multi-frequency electrical impedance tomography (EIT) system called the KHU Mark2. It is descended from the KHU Mark1 in terms of technical details such as digital waveform generation, Howland current source with multiple generalized impedance converters and digital phase-sensitive demodulators. New features include flexible electrode configurations to accommodate application-specific requirements, multiple independent current sources and voltmeters for fully p

We describe the development of a multi-frequency electrical impedance tomography (EIT) system (KHU Mark1) with a single balanced current source and multiple voltmeters. It was primarily designed for imaging brain function with a flexible strategy for addressing electrodes and a frequency range from 10 Hz-500 kHz. The maximal number of voltmeters is 64, and all of them can simultaneously acquire and demodulate voltage signals. Each voltmeter measures a differential voltage between a pair of elect

Validation and interpretation of reconstructed images using a multi-frequency electrical impedance tomography (mfEIT) requires a conductivity phantom including imaging objects with known complex conductivity (sigma + iomegaepsilon) spectra. We describe imaging experiments using the recently developed mfEIT system called the KHU Mark1 with the frequency range of 10 Hz to 500 kHz. Using a bio-impedance spectroscopy (BIS) system, we first measured complex conductivity spectra of different imaging o

Multi-channel multi-frequency electrical impedance tomography (EIT) systems require a careful calibration to minimize systematic errors. We describe novel calibration methods for the recently developed KHU Mark1 EIT system. Current source calibration includes maximization of output resistance and minimization of output capacitance using multiple generalized impedance converters. Phase and gain calibrations are used for voltmeters. Phase calibration nulls out the total system phase shift in measu

Current sources are widely used in bio-impedance spectroscopy (BIS) measurement systems to maximize current injection for increased signal to noise while keeping within medical safety specifications. High-performance current sources based on the Howland current pump with optimized impedance converters are able to minimize stray capacitance of the cables and setup. This approach is limited at high frequencies primarily due to the deteriorated output impedance of the constant current source when s

When we use a conductive fabric as a pressure sensor, it is necessary to quantitatively understand its electromechanical property related with the applied pressure. We investigated electromechanical properties of three different conductive fabrics using the electrical impedance spectroscopy (EIS). We found that their electrical impedance spectra depend not only on the electrical properties of the conductive yarns, but also on their weaving structures. When we apply a mechanical tension or compre

BACKGROUND: Electrical impedance tomography (EIT) has been used for functional lung imaging of regional air distributions during mechanical ventilation in intensive care units (ICU). From numerous clinical and animal studies focusing on specific lung functions, a consensus about how to use the EIT technique has been formed lately. We present an integrated EIT system implementing the functions proposed in the consensus. The integrated EIT system could improve the usefulness when monitoring of mec

We performed in vivo disease model animal experiments to validate the MREIT technique providing conductivity information of tissues in situ to be utilized in clinical applications.

Electrical Impedance Tomography (EIT) is a very attractive functional imaging method despite the low sensitivity and resolution. The use of internal electrodes with the conventional reconstruction algorithms was not enough to enhance image resolution and accuracy in the region of interest (ROI). We propose a local ROI imaging method with internal electrodes developed from careful analysis of the sensitivity matrix that is designed to reduce the sensitivity of the voxels outside the local region

We describe a new multi-frequency technique for breast cancer detection. Applying a constant voltage with multiple sinusoidal frequencies between a reference electrode on a distal part of a patient and a scan probe placed on the breast, we measure exit currents from an array of electrodes inside the probe that are kept at the ground potential. The distribution of measured exit currents is called the trans-admittance map and the instrument is called the trans-admittance scanner (TAS). We assume a

Efficient connection of multiple electrodes to the body for impedance measurement and voltage monitoring applications is of critical importance to measurement quality and practicality. Electrical impedance tomography (EIT) experiments have generally required a cumbersome procedure to attach the multiple electrodes needed in EIT. Once placed, these electrodes must then maintain good contact with the skin during measurements that may last several hours. There is usually also the need to manage the

BACKGROUND: Modern EIT systems require simultaneously operating multiple functions for flexibility, interoperability, and clinical applicability. To implement versatile functions, expandable design and implementation tools are needed. On the other hand, it is necessary to develop an ASIC-based EIT system to maximize its performance. Since the ASIC design is expensive and unchangeable, we can use FPGAs as a prior step to the digital ASIC design and carefully classify which functions should be inc

BACKGROUND: Non-destructive continuous monitoring of regenerative tissue is required throughout the entire period of in vitro tissue culture. Microscopic electrical impedance tomography (micro-EIT) has the potential to monitor the physiological state of tissues by forming three-dimensional images of impedance changes in a non-destructive and label-free manner. We developed a new micro-EIT system and report on simulation and experimental results of its macroscopic model. METHODS: We propose a new

Magnetic resonance electrical impedance tomography (MREIT) aims to produce high-resolution cross-sectional images of conductivity distribution inside the human body. Injected current into an imaging object induces a distribution of internal magnetic flux density, which is measured by using an MRI scanner. We can reconstruct a conductivity image based on its relation with the measured magnetic flux density. In this paper, we explain the contrast mechanism in MREIT by performing and analyzing a se

We demonstrated the feasibility of time difference and weighted frequency difference conductivity imaging for real-time monitoring of temperature distribution and ablation region estimation during radiofrequency (RF) ablation. The electrical conductivity spectrum of biological tissue reflects mobility of ions in intra- and extra-cellular fluids and changes in cellular morphology induced by heating. The time series conductivity spectra were measured in an ex vivo bovine liver by a high-speed elec