Geon Ho Kim

The standardized techniques of blood pressure (BP) measurement in the clinic are emphasized and it is recommended to replace the mercury sphygmomanometer by a non-mercury sphygmomanometer. Out-of-office BP measurement using home BP monitoring (HBPM) or ambulatory BP monitoring (ABPM) and even automated office BP (AOBP) are recommended to correctly measure the patient’s genuine BP. Hypertension (HTN) treatment should be individualized based on cardiovascular (CV) risk and the level of BP. Based o

The increase in the number and complexity of process levels in semiconductor production has driven the need for the development of new measurement methods that can evaluate semiconductor devices at the critical dimensions of fine patterns and simultaneously inspect nanoscale contaminants or defects. However, conventional optical inspection methods often fail to resolve device patterns or defects at the level of tens of nanometers required for device development owing to their diffraction-limited

Recent advances in single‐molecule spectroscopic imaging techniques, such as spectrally resolved stochastic optical reconstruction microscopy (SR‐STORM), have been effective for obtaining detailed spectral information at the molecular level. However, its application for single‐molecule sensing is highly challenging owing to its complicated configuration and limited spectral information. In this study, we demonstrated single‐molecule polarity sensing by combining grating‐based SR‐STORM with the s

The rapid response system (RRS) is an innovative system designed for in-hospital, at-riskpatients but underutilization of the RRS generally results in unexpected cardiopulmonaryarrests. We implemented an extended RRS (E-RRS) that was triggered by actively screeningat-risk patients prior to calls from primary medical attendants. These patients wereidentified from laboratory data, emergency consults, and step-down units. A fourmemberrapid response team was assembled that included an ICU staff, and

The recent development of super-resolution fluorescence microscopy (SRM) has drastically improved the resolution of light microscopy to the order of tens of nanometers. However, the application of SRM to semiconductor materials remains challenging because fluorophore labeling on inorganic materials with a high labeling density required for nanoimaging has been limited with conventional surface functionalization methods. Here, a novel approach for highly dense material-specific fluorophore labeli

The Korean Society of Hypertension guideline defines hypertension as systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg, where the effectiveness of pharmacological treatment has been established. It is confirmed that higher blood pressure levels are associated with increased risk of cardiovascular disease and mortality also in the Korean population. About one third of Korean adults aged 30 years or older are estimated to have hypertension, and the prevalence of hypertension

For Korean dialysis patients, chronic kidney disease–mineral bone disorder is aserious burden because of cardiovascular calcification and mortality. However,recent epidemiologic data have demonstrated that many patients undergoingmaintenance hemodialysis are out of the target ranges of serum calcium, phosphorus,and intact parathyroid hormone. Thus, we felt the necessity for thedevelopment of practical recommendations to treat abnormal serum phosphorus,calcium, and iPTH in dialysis patients. In t

Background: The aim of this multicenter study was to evaluate the safety and efficacy of tolvaptan (TLV) in Korean patients with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Methods: Of 51 enrolled patients with SIADH, 39 patients (16 female patients, aged 70.8 ± 11.3 years) were included in an intention to treat analysis. All patients received 15 mg/day as the initial dose, and the dose was then increased up to 60 mg/day (as needed) until day 4. Results: Serum sodium

목 적 : 급성신우신염에서는 quinolone 제제가 경험적 항생제요법으로서 흔히 사용되지만 초치료에 실패하는 경우가 간혹 있다. 1999년 미국감염학회 지침에서 trimethoprim-sulfamethoxazole의 내성률이 20% 이상인 지역에서는 요로감염증 초치료로 quinolone 사용을 권하여, quinolone을 사용하고 있으나 사용빈도 증가에 따른 내성 증가가 우려된다. 이에 연구자들은 지역사회획득 급성신우신염에서 현재 차지하는 quinolone 내성의 분포와 quinolone 내성균에 의한 임상적 특징을 조사하고자 하였다.방 법 : 2002년 1월부터 2004년 12월까지 한양대학교병원 신장내과에 입원하여 급성신우신염으로 진단된 367명의 자료를 후향적으로 분석하였다. 입원 중 발생한 병원감염은 제외하였고, quinolone에 대한 감수성 환자군과 내성 환자군을 비교하였다.결 과 : 총 367명 환자 중 241명 (65.7%)에서 요배양에서 균이 동정되었고 이 중 21

Background: We investigated the associations between mineral metabolism parameters and mortality to identify optimal targets in Korean hemodialysis patients. Methods: Among hemodialysis patients registered in the end-stage renal disease registry of the Korean Society of Nephrology between March 2012 and June 2017, those with serum calcium, phosphorus, and intact parathyroid hormone (iPTH) measured at enrollment were included. Association of serum levels of calcium, phosphorus, and iPTH with all-

Background: In many countries, nephrologists follow clinical practice guidelines for mineral bone disorders to control secondary hyperparathyroidism (SHPT) associated with abnormal serum calcium (Ca) and phosphorus (P) levels in patients undergoing maintenance hemodialysis (MHD). The Kidney Disease Outcomes Quality Initiative (KDOQI) Guidelines have long been used in Korea, and this study was undertaken to investigate the current status of serum Ca and P control in MHD patients. Methods: Data we

Claudins are strategically located to exert their physiologic actions along with the nephron segments from the glomerulus. Claudin-1 is normally located in the Bowman’s capsule, but its overexpression can reach the podocytes and lead to albuminuria. In the proximal tubule (PT), claudin-2 forms paracellular channels selective for water, Na+, K+, and Ca2+. Claudin-2 gene mutations are associated with hypercalciuria and kidney stones. Claudin-10 has two splice variants, -10a and -10b; Claudin-10a a

Purpose: Oral adsorbents delay disease progression and improve uremic symptoms in patients with chronic kidney disease(CKD). DW-7202 is a newly developed oral adsorbent with high adsorptive selectivity for uremic toxins. We evaluated patientpreference for and adherence to DW-7202 versus AST-120 therapy and compared treatment efficacy and safety in patients withpre-dialysis CKD. Materials and Methods: A seven-center, randomized, open-label, two-way crossover, active-controlled, phase IV clinical

목 적: 혈액투석 환자에서 적혈구생성자극제 사용에 따른 헤모글로빈 변이성 (variability)이 알려져 있다. 현재 임상에서 사용중인 적혈구생성자극제의 약력학 및 약물동력학은 서로 다르므로, 그에 따라 헤모글로빈 변이성에 차이가 있을 가능성이 있다. 방 법: 2007년 1월부터 12월까지 적혈구생성자극제를 사용하는 유지혈액투석 환자로서 중 급성 병증이 없었던 72명 (darbepoetin alfa 27명, epoetin beta 27명, and epoetin alpha 18명)을 대상으로 헤모글로빈 변이성을 조사하였다. 변이성의 지표로서 헤모글로빈 싸이클링, 헤모글로빈 변동 (variance) 및 헤모글로빈 표준편차/평균 비를 각각 구하여 비교하였다. 헤모글로빈 싸이클링은 진폭 >1.5 g/dL, 주기의 지속기간 ≥2개월인 경우로 정의하였다. 결 과: 총 72명 중 53명 (73.6%)에서 헤모글로빈 사이클링이 관찰되었다. 헤모글로빈 사이클링의 빈도 (평균±표준편차)는 1.4±0

Background: The aim of this study is to narrow the gap between global guidelines and local practices, we recently established domestic recommendations by adapting the international guidelines for management of chronic kidney disease-mineral bone disorder (CKD-MBD) in patients on maintenance hemodialysis (MHD). This study was undertaken to determine whether application of this guideline adaptation was associated with improved serum mineral profiles in patients with CKD-MBD. Methods: A total of 35