Go-Won No
Yonsei University · Medicine
About the Lab
Professor Go-Won No's research lab specializes in perioperative medicine, with a focus on optimizing anesthetic techniques to minimize surgical stress and organ injury. The lab investigates the impact of anesthetic agents—particularly propofol—on systemic inflammation, ischemia-reperfusion injury, and end-organ protection during major surgical procedures. Key research directions include the use of regional anesthesia (e.g., thoracic epidural anesthesia), the role of anesthetic agents in modulating cellular signaling (such as cAMP pathways), and strategies to improve airway management and oxygenation in challenging clinical scenarios. The lab also explores biomarkers and clinical outcomes related to acute kidney injury and organ dysfunction following cardiac and vascular surgery.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15TEA combined with general anesthesia improved intraoperative ventilation/oxygenation. Although clinical and radiologic pulmonary complications were not significantly influenced, TEA can be considered an option for patients with limited reserve capacity or preexisting impairments of visceral blood flow.
Abstract Robot-assisted laparoscopic radical prostatectomy (RALRP) is a minimally invasive procedure; however, some amount of surgical trauma that can trigger systemic inflammation remains. Moreover, pneumoperitoneum during RALRP induces ischemia–reperfusion injury (IRI). Propofol, an anesthetic, is known to have anti-inflammatory and antioxidant properties. In the present study, we compared the effects of propofol with those of desflurane on inflammation and IRI during RALRP via measurements of
1.
Abstract Background Airway management is a part of routine anesthetic procedures; however, serious complications, including hypoxia and death, are known to occur in cases of difficult airways. Therefore, alternative techniques such as fiberoptic bronchoscope-assisted intubation (FOB intubation) should be considered, although this method requires more time and offers a limited visual field than does intubation with a direct laryngoscope. Oxygen insufflation through the working channel during FOB
Background and Goal of Study: Previous studies reported a high incidence of acute kidney injury (AKI) after thoracic aortic surgery in heterogeneous patient cohort, including various aortic pathologies and the use of deep hypothermic cardiac arrest. Moderate hypothermia with selective cerebral perfusion makes deep hypothermia non-essential but can make end-organ susceptible to ischemia during circulatory arrest. We investigated incidence and risk factors of AKI after graft replacement of thoraci
BACKGROUND: Propofol may decrease myocardial contractility via actions on the beta-adrenoceptor-mediated signal transduction. The aim of this study was to evaluate the effect of propofol via beta-adrenoceptor-mediated signal transduction by measuring the tissue levels of cAMP (cyclic adenosine monophosphate). METHODS: The effects of propofol on beta-adrenoceptor mediated cascades were measured with cAMP concentrations, which were stimulated by agonists (l-isoproterenol, GTPgammaS, and forskolin)
Clinicaltrials.gov identifier: NCT01825720.
Sedation can increase patient comfort during spinal anaesthesia. Understanding the relationship between the propofol effect-site concentration (Ce) and patient sedation level could help clinicians achieve the desired sedation level with minimal side effects. We aimed to model the relationship between the propofol Ce and adequate and deep sedation and also incorporate covariates. Thirty patients scheduled for orthopaedic surgery received spinal anaesthesia with 0.5% bupivacaine. Propofol was admi
The real-time palpation method during intubation using an ETT with a preloaded stylet is an instantly applicable technique with good discrimination ability. The addition of real-time information through this palpation method to the conventional intubation process, especially in patients with poor vocal cord visualization, would be useful to facilitate the process of safe and careful endotracheal intubation.
The findings of this preliminary exploratory observational study suggest that it is possible for withdrawal movement following rocuronium injection during anesthesia induction to reflect pain sensitivity of pediatric patients, which in turn may be useful in identifying those at risk of severe EA on admission to the PACU among preschool children undergoing inguinal herniorrhaphy. Further studies with a larger sample size are required to validate these findings. The exact correlation between pain
Yonsei University College of Medicine, Department of Anaesthesiology and Pain Medicine, Seoul, Korea, Republic of
Research Areas
Dive deeper into Go-Won No's research on Nubint
Open this lab's papers in the app to read with AI, summarize, and cite in your writing.