Guk-rae Kim
Yonsei University
About the Lab
Professor Guk-rae Kim's research lab focuses on interdisciplinary biomedical and clinical engineering research, spanning neuromodulation, regenerative medicine, and precision healthcare. The lab investigates molecular mechanisms in neurodegenerative diseases such as Parkinson’s, explores gut microbiome alterations in chronic kidney disease, and develops innovative medical devices and surgical techniques—such as tactile feedback systems and secure T-tube insertion methods. Additionally, the lab examines socio-financial dynamics in corporate governance, particularly within Korean business groups, linking financial behavior to market reactions.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
2Glycogen synthase kinase-3β (GSK3β) is a highly conserved kinase that functions as a key regulator of many cellularsignalling pathways. Unlike other kinases, GSK3β transduces signalling via inhibition by upstream kinases or factors. Inthe Wnt/β-catenin signalling pathway, the Wnt coreceptor LRP6/5 serves as a direct inhibitor of GSK3β when the PPPSPmotif in LRP6/5 is phosphorylated upon Wnt activation. We constructed a chimeric protein composed of the PPPSP motifand the mouse GSK3β to determine
G-protein-coupled receptors (GPCRs) are seven-transmembrane proteins that play important roles in signal transductionfrom the extracellular compartment to the cytoplasm. GPCR malfunction has been implicated in various diseases such ascancer, allergy, neuronal disease, rheumatism, and obesity. Because of the importance of GPCRs, GPCR-targeting drugsoccupy approximately 40% of the total drug market. Recently, three-dimensional structures of many GPCRs have beensuccessfully ascertained on the basis
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