Gyu-Seon Jeong
Yonsei University · Biochemistry, Genetics and Molecular Biology
About the Lab
Professor Gyu-Seon Jeong's research lab specializes in clinical and molecular genetics, with a primary focus on chromosomal microdeletions and their implications in neurodevelopmental disorders. The lab investigates the genetic mechanisms underlying Prader-Willi syndrome (PWS) and growth hormone deficiency (GHD), particularly through advanced molecular techniques such as FISH with SNRPN probes and molecular analysis of GH receptor expression in adipose tissue. Research directions include improving diagnostic accuracy for microdeletion syndromes and evaluating the metabolic and body composition effects of growth hormone therapy in pediatric patients. The lab integrates cytogenetic, molecular, and clinical imaging approaches to understand genotype-phenotype correlations in endocrine and genetic diseases.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
2Purpose : To detect microdeletion of 15q11-13 region, high resolution cytogenetic analysis or FISH with probe at Prader-Willi syndrome region can be used. We tried to evaluate whether FISH with SNRPN is a more effective method than G-banding microscope in the diagnosis of Prader-Willi syndrome. Methods : Peripheral blood sampling was done on five patients who we suspected of Prader-Willi syndrome clinically and lymphocytes from peripheral blood sampling were cultured. G-banding microscope was us
Purpose : Growth hormone(GH) is a powerful inhibitor of lipoprotein lipase and is known to decrease fat cell mass. The lipolytic effect has more pronounced influence on visceral fat than subcutaneous fat. The effects of GH therapy on GH receptor in fat tissue are not clear. We in- vestigated the changes in fat tissue and GH receptor mRNA in adipose tissue with GH therapy. Methods : Eight children with growth hormone deficiency(GHD) and 9 children with Prader-Willi syndrome(PWS) were studied. The
Research Areas
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