Haeseon Sim
Sungkyunkwan University · Medicine
About the Lab
Professor Haeseon Sim's research lab specializes in clinical and translational studies focusing on perioperative organ injury, particularly acute kidney injury (AKI) in major surgical procedures such as liver and thoracic aortic surgery. The lab investigates modifiable risk factors, develops predictive scoring models, and explores underlying pathophysiological mechanisms, including hemodynamic and cellular pathways involving calcium signaling and nitric oxide. Additional research extends to metabolic syndrome and its associations with complications such as hearing loss and poor recovery from critical conditions.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Acute kidney injury (AKI) is a frequent complication of liver transplantation and is associated with increased mortality. We identified the incidence and modifiable risk factors for AKI after living-donor liver transplantation (LDLT) and constructed risk scoring models for AKI prediction. We retrospectively reviewed 538 cases of LDLT. Multivariate logistic regression analysis was used to evaluate risk factors for the prediction of AKI as defined by the RIFLE criteria (RIFLE = risk, injury, failu
The rate of recovery from SSNHL was lower among patients with metabolic syndrome than among those without metabolic syndrome, and prognosis was poorer in patients with 4 or more diagnostic factors of the metabolic syndrome.
Perioperative risk factors were identified for acute kidney injury (AKI) defined by the RIFLE criteria (RIFLE = risk, injury, failure, loss, end stage) after surgery on the thoracic aorta with cardiopulmonary bypass (CPB) in this case-control study. A retrospective review was completed for 702 patients who underwent surgery on the thoracic aorta with CPB. A total of 183 patients with AKI were matched 1:1 with patients without AKI by a propensity score. Matched variables included age, gender, bod
Intravenous lipid emulsions (LEs) are effective in the treatment of toxicity associated with various drugs such as local anesthetics and other lipid soluble agents. The goals of this study were to examine the effect of LE on left ventricular hemodynamic variables and systemic blood pressure in an in vivo rat model, and to determine the associated cellular mechanism with a particular focus on nitric oxide. Two LEs (Intralipid(®) 20% and Lipofundin(®) MCT/LCT 20%) or normal saline were administere
Taken together, these results suggest that dexmedetomidine-induced contraction is primarily dependent on extracellular calcium concentrations that contribute to calcium influx via voltage-operated calcium channels of isolated rat aortic smooth muscle. Dexmedetomidine-induced contraction is mediated by α(2)-adrenoceptor stimulation. Dexmedetomidine-induced contraction appears to be partially mediated by calcium release from the sarcoplasmic reticulum.
MetS may be associated with hearing loss, especially in subjects who meet four or five of the diagnostic criteria for MetS.
The study results suggested that the CP group received effective treatment modalities for ISSNHL. The combined therapy of lipo-PGE<sub>1</sub> with carbogen inhalation in patients with ISSNHL was more beneficial than other treatment modalities.
Tracheobronchial rupture due to blunt chest trauma is an uncommon injury and the clinical presentations are variable.Recently, the incidence of tracheobronchial injuries has increased with the increase in traffic accidents and mechanization.The early diagnosis and primary repair of tracheobronchial rupture not only restores normal lung function, but also avoids the difficulties and complications associated with delayed diagnosis and repair.We report our clinical experience in anesthetic manageme
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Tethered cord syndrome is a form of spinal dysraphism, with a low-lying conus frequently associated with an intraspinal lipoma, diastematomyelia or fibrous band. The clinical manifestations include spine abnormalities, such as spina bifida, or various neurological symptoms involving the lower extremities and sphincters. Herein, our experience of a 42-year-old female tethered cord syndrome patient, with deficit, paresthesia and incontinence following spinal anesthesia for anti-incontinence surger
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Background: The authors evaluated the hemodynamic effects of body position measured by esophageal Doppler monitor (EDM) during laparoscopic cholecystectomy or gynecologic laparoscopic surgery. Methods: Fifty patients scheduled to undergo laparoscopic cholecystectomy (Group C) or gynecologic laparoscopic surgery (Group G), were divided into two groups. Pneumoperitoneum was instituted by CO2 gas and the intraperitoneal pressure was kept under 12 mmHg. Hemodynamic parameters at critical points were
Research Areas
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