Hasuk Bae
Ewha Womans University · Medicine
About the Lab
Professor Hasuk Bae's research lab specializes in regenerative medicine and soft tissue repair, with a focus on extracorporeal shock wave therapy (ESWT) for musculoskeletal and lymphatic disorders, including post-stroke spasticity and secondary lymphedema after breast cancer. The lab investigates novel mechanisms of shock wave-induced cellular responses, such as siRNA transfection via microparticles, and explores bioactive agents like polydeoxyribonucleotide (PDRN) for chronic wound healing. Advanced imaging techniques, including CT volumetry, are employed to objectively assess treatment outcomes in clinical settings. The lab integrates translational research with clinical applications to improve functional recovery and tissue regeneration.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15OBJECTIVE: To investigate the clinical effect of extracorporeal shock wave therapy (ESWT) in patients with secondary lymphedema after breast cancer treatment. METHODS: In a prospective clinical trial, ESWT was performed consecutively 4 times over two weeks in 7 patients who were diagnosed with stage 3 secondary lymphedema after breast cancer treatment. Each patient was treated with four sessions of ESWT (0.056-0.068 mJ/mm(2), 2,000 impulses). The parameters were the circumference of the arm, thi
Objective : To evaluate the immediate and short term effects of extracorporeal shock wave therapy (ESWT) on elbow flexor spasticity after stroke, to compare the treatment effects according to the ESWT applied site (muscle group and musculotendinous junction group) and to assess the factors affecting the treatment effect. Method : A total of 32 stroke patients were enrolled, 23 of them were ESWT group and 9 were control group. ESWT was applied 1 session/week, total 3 sessions and 12 patients were
The quiet standing balance of the patients was influenced by somatosensory limitations or insufficient visual compensation. We should try to improve the postural balance and functional independence of patients through proper proprioceptive and lower extremity strength training for better postural and pedal control, and to make efforts to minimize environmental hazards.
Two patients with stage three secondary lymphedema of the upper extremities underwent treatment for breast cancer, including surgery, chemotherapy, and radiotherapy. They were examined with computed tomography (CT) before and after extracorporeal shock wave therapy (ESWT). We used a manual tracing method using PiViewSTAR software to calculate the volume of the upper extremities. There was a decrease in the volume of the subcutaneous compartment measured by CT before and after ESWT. CT may be hel
Polydeoxyribonucleotide (PDRN) is safe and effective in wound healing, cellular growth, synthesis of extracellular matrix protein, and inflammation reduction via activation of adenosine A2 receptors. We report a 28-year-old male patient treated with PDRN injections for chronic non-healing wound refractory to negative pressure wound therapy, skin graft, or growth factors. Three injections of PDRN were administered at the wound site into the anterior and medial sides of the left stump on the 1st,
OBJECTIVE: To discuss the association between the length of stay at the intensive care unit (ICU) and sarcopenia among hemiplegic stroke patients. METHODS: This study evaluated 66 hemiplegic stroke patients with history of ICU admission using handgrip strength and bioelectrical impedance analysis to obtain height-adjusted appendicular skeletal muscle mass. The diagnosis of sarcopenia was made according to the muscle mass based on the Asian Working Group for Sarcopenia. The patients were divided
Extracorporeal shock wave (SW) therapy has been studied in the transfection of naked nucleic acids into various cell lines through the process of sonoporation, a process that affects the permeation of cell membranes, which can be an effect of cavitation. In this study, siRNAs were efficiently transfected into primary cultured cells and mouse tumor tissue via SW treatment. Furthermore SW-induced siRNA transfection was not mediated by SW-induced sonoporation, but by microparticles (MPs) secreted f
OBJECTIVE: To evaluate the gait pattern of patients with gait disturbances without consideration of defilades due to assistive devices. This study focuses on gait analysis using the inertial measurement unit (IMU) system, which can also be used to determine the most appropriate assistive device for patients with gait disturbances. METHODS: Records of 18 disabled patients who visited the Department of Rehabilitation from May 2018 to June 2018 were selected. Patients' gait patterns were analyzed u
보행 재활 훈련용 보행보조 로봇을 개발하고, 시제품의 운동학적 특성을 평가하였다. 이 보행보조 로봇은 고관절(hip), 슬관절(knee), 족관절(ankle) 등으로 구성되며, 각 관절은 감속기가 포함된 모터에 의해 구동된다. 인체 보행 운동을 이론적으로 해석하여, 보행 운동 중 각 관절의 각도 변위를 계산하는 식을 구하였고, 계산된 각도 변위를 로봇 구동기에 입력하였다. 트레드밀(treadmill) 위에서의 실험을 통해 다양한 보행 속도(walking speed) 및 보폭(stride)에서 각 관절의 출력 각도 변위를 측정하고 입력 값과 비교하였다. 입력 각도 변위와 출력 각도 변위의 차이가 고관절에서는 5.22%, 슬관절에서는 2.97% 이내로 일치함을 확인하여, 설계대로 보행보조 로봇이 작동함을 입증하였다.
BACKGROUND: Diabetes mellitus (DM) is a significant public health concern, particularly in the elderly population. Absolute handgrip strength (HGS) serves to quantify muscle strength. It is recommended that the risk of low muscle strength and increased body mass index be concurrently evaluated using relative HGS. There are currently insufficient evidence regarding the relationship between relative HGS and DM in the elderly Korean population. Therefore, the association between relative HGS and th
Objective: To investigate whether drooling in patients with traumatic brain injury (TBI) is due to hypersalivation or cognitive dysfunction or disability. Method: The subjects were 24 TBI patients with drooling and 17 TBI patients without drooling and 20 unaffected healthy volunteers who had no known physical or mental disabilities. All participants had no known history of diabetes mellitus, hypertension, thyroid dysfunction or chronic alcoholism. And, we excluded the subjects who take the antic
Research Areas
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