Hee Won Seo
Hanyang University · Neuroscience
About the Lab
Professor Hee Won Seo's research lab specializes in vestibular and auditory disorders, with a primary focus on idiopathic sudden sensorineural hearing loss (ISSNHL). The lab investigates the underlying mechanisms of inner ear dysfunction, including semicircular canal and otolith organ involvement, using advanced diagnostic tools such as video-head impulse testing and vestibular-evoked myogenic potentials. Recent work also emphasizes clinical applications, including predictive modeling using deep learning and the development of smartphone-based hearing assessment technologies for improved accessibility. The lab further explores molecular markers in ovarian cancer, particularly claudin gene expression, reflecting a multidisciplinary approach to biomedical research.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15OBJECTIVE: The aim of this study was to investigate patterns of semicircular canal (SCC) and otolith organ dysfunction by vestibular mapping, and to determine the clinical implications of treatment outcomes in idiopathic sudden sensorineural hearing loss (ISSNHL). METHODS: We retrospectively reviewed 135 consecutive patients diagnosed with ISSNHL from January 2016 to December 2020. Patients underwent video-head impulse tests (vHIT) for each SCC, cervical vestibular-evoked myogenic potential test
OBJECTIVE: The aim of this study was to investigate the clinical implications of diabetes for the management of idiopathic sudden sensorineural hearing loss (ISSNHL). STUDY DESIGN: Retrospective study. SETTING: Tertiary referral center. SUBJECTS AND METHODS: ISSNHL patients (N = 403) who received inpatient management between January 2015 and December 2018 were analyzed. All were managed by a uniform treatment protocol of high-dose steroid therapy and salvage intratympanic steroid injections. Tre
INTRODUCTION: The aim of this study was to investigate the expression profiles of claudin (CLDN) gene family members between normal and cancerous ovaries of White Leghorn hens. METHODS: For the detection of ovarian cancer, 120-week-old White Leghorn hens (n = 40) that could not produce eggs for at least 2 months were humanely killed, and candidate cancerous ovaries were stained with hematoxylin and eosin. The existence of CLDN genes in normal and cancerous ovaries was confirmed by reverse transc
This study aimed to establish a deep learning-based predictive model for the prognosis of idiopathic sudden sensorineural hearing loss (SSNHL). Data from 1108 patients with SSNHL between January 2015 and May 2023 were retrospectively analyzed. Patients underwent standardized treatment protocols including high-dose steroid therapy and hearing outcomes were assessed after three months using Siegel's criteria and the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) classification.
Pure-tone audiometry (PTA) is the gold standard for assessing hearing loss. However, traditional PTA tests require specialized equipment, trained personnel, and a soundproof environment. Recently, smartphone-based PTA tests have been developed as an alternative method for hearing assessment. The aim of this study was to validate the accuracy and reliability of a smartphone application-based audiometry test. This study was conducted to assess the performance of application-based audiometry from N
OBJECTIVES: Acute low-tone sensorineural hearing loss (ALHL) is thought to have a different etiology from that of idiopathic sudden sensorineural hearing loss. We hypothesized that endolymphatic hydrops (EH) in the inner ear organ contributes to ALHL, even in patients without vertigo. This study investigated the presence of EH in ALHL and compared the clinical characteristics of patients with or without EH. METHODS: We retrospectively reviewed 38 patients diagnosed with ALHL without vertigo from
More people use the internet for medical information, especially YouTube. Nevertheless, no study has been conducted to analyze the quality of YouTube videos about tinnitus in Korea. This study aims to review the contents and quality of YouTube videos on tinnitus. The top 100 Korean YouTube videos on tinnitus were reviewed by a tinnitus expert. This study assessed video details: title, creator, length, and popularity indicators-subscribers, views, and likes. The contents of the video clips were a
BACKGROUND: Hearing level reference values based on the results of recent audiometry have not been established for the general population of South Korea. This study aimed to evaluate the mean hearing levels of each age group and to measure the annual progression of hearing loss. METHODS: We used the database of the eighth and ninth Korea National Health and Nutrition Examination Survey from 2020 to 2022, and included participants with normal tympanic membranes and without occupational noise expo
Cochlear synaptopathy refers to a subclinical hearing pathology which could potentially explain hearing difficulties within the normal hearing threshold; it is also called “hidden hearing loss”. We hypothesized that a temporary threshold shift in sudden sensorineural hearing loss (ISSNHL) also affects the function in the synapse. The aim of the study was to evaluate the presence of cochlear synaptopathy in patients who had completely recovered from unilateral SSNHL Nineteen patients who had comp
OBJECTIVES: Hearing loss is recognized as a potentially modifiable risk factor for dementia in midlife. This study aimed to investigate the association between rehabilitation methods and dementia risk in patients with severe to profound hearing loss. DESIGN: Using the nationwide population data from South Korea, individuals with severe to profound hearing loss were identified. Individuals aged 40 to 79 were then divided into 3 groups according to the type of auditory rehabilitation they received
OBJECTIVES: Hearing loss causes numerous functional deficits. However, few studies have been conducted to assess the association between hearing loss and physical inactivity. This study aimed to evaluate the physical activity and sedentary behavior of hearing loss patients and their relation with the use of hearing aids. MATERIALS AND METHODS: We extracted participants over 60 years of age with information on hearing status and physical activities from the eighth Korea National Health and Nutrit
BACKGROUND: Some studies have described a relationship between hearing loss and the number of teeth. However, a connection between treatment for tooth loss and hearing improvement remains uncertain. This study aimed to evaluate the association between hearing loss and the number of natural teeth, as well as the association between hearing improvement and dental implants. METHODS: Relevant subjects were retrieved from participants in the 8th Korea National Health and Nutrition Examination Survey
Background and Objectives We aimed to compare the treatment outcomes of primary intratympanic steroid (ITS) and the salvage ITS protocol.Subjects and Method We assessed 440 patients with unilateral idiopathic sudden sensorineural hearing loss (ISSNHL) from January 2016 to December 2019. Of the 440 patients, 37 patients received ITS only as a primary treatment while other patients received systemic steroid; of those remaining patients, 276 received systemic steroid as well as ITS as a salvage tre
Research Areas
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