Heesu Park

Background: Telomere shortening is thought to be involved in the pathophysiology of myeloid malignancies, but telomere lengths (TL) during interphase and metaphase in hematopoietic malignancies have not been analyzed. We aimed to assess the TLs of interphase and metaphase cells of MDS and telomerase activity (TA) and to find out prognostic significances of TL and TA. Methods: The prognostic significance of TA by quantitative PCR and TL by quantitative fluorescence in situ hybridization (QFISH) o

Abstract The purpose of study was to evaluate that kallistatin deficiency causes excessive production of reactive oxygen species and exacerbates neuronal injury after cardiac arrest. For in vitro study, kallistatin knockdown human neuronal cells were given ischemia–reperfusion injury, and the oxidative stress and apoptosis were evaluated. For clinical study, cardiac arrest survivors admitted to the ICU were divided into the good (CPC 1–2) and poor (CPC 3–5) 6-month neurological outcome groups. T

BACKGROUND: We hypothesized that an emergency short-stay ward (ESSW) mainly operated by emergency medicine physicians may reduce the length of patient stay in emergency department without expense of clinical outcomes. METHODS: We retrospectively analysed adult patients who visited the emergency department of the study hospital and were subsequently admitted to wards from 2017 to 2019. We divided study participants into three groups: patients admitted to ESSW and treated by the department of emer

During recovery from septic shock, circulating mitochondrial N-formyl peptides predispose to secondary infection by occupying formyl peptide receptor 1 on the neutrophil (polymorphonuclear leukocyte) membrane, suppressing cytosolic calcium ([Ca2+]i)-dependent responses to secondarily encountered bacteria. However, no study has yet investigated therapeutic clearance of circulating mitochondrial N-formyl peptides in clinical settings. Thus, we studied how to remove mitochondrial N-formyl peptides

BACKGROUND: Recently, we developed a chest compression device that can move the chest compression position without interruption during CPR and be remotely controlled to minimize rescuer exposure to infectious diseases. The purpose of this study was to compare its performance with conventional mechanical CPR device in a mannequin and a swine model of cardiac arrest. MATERIALS AND METHODS: A prototype of a remote-controlled automatic chest compression device (ROSCER) that can change the chest comp

본고는 박지원의 ‘意’ 개념의 의미에 대해 해명하고 이를 바탕으로 박지원의 법고창신론에 대해 재음미해 보는 것을 목표로 삼는다. 그 결과는 다음과 같다. 박지원의 ‘의’ 개념과 관련된 중요한 특성은 전범의 형식을 모방하는 일이 작자의 ‘의’를 왜곡하는 결과를 가져온다는 점이며, 따라서 글쓰기에서 요구되는 것은 ‘의’를 왜곡되지 않은 상태로 보존하는 것이다. 이러한 ‘의’는 주관적 정념의 차원에 국한되지 않으며 외적 대상을 포괄하는 것으로 드러나는데, 그러면서도 주관적 유심론과 같이 내면에 인식된 상태의 대상이 있는 그대로의 진실이라 보는 입장은 선택되지 않는다. 양명학과 관련하여 박지원의 ‘際’ 개념을 해석한 최근의 연구 결과를 반영하면, ‘의’는 작자의 뜻을 가리키되 이 뜻은 주관과 객관의 상호 교융 속에서만 존재하는 것으로 파악된다. 그래서 객관 없이 미리 존재하는 주체의 정념․사고는 없으며, 또 주체의 정념․사고를 벗어나 존재하는 객관 또한 ‘의’에 포착된 대상과는 무관한 것이

ABSTRACT: Objective: This study aimed to test whether the prognostic value of tryptophanyl-tRNA synthetase 1 (WARS1) for 28-day mortality in patients with sepsis was affected by monocytopenia. Methods: A prospective analysis of retrospectively collected samples from 74 sepsis patients was performed. WARS1, C-reactive protein (CRP), and procalcitonin were measured at admission and 24 and 72 h after admission. The prognostic value of WARS1, CRP, and procalcitonin for 28-day mortality was compared

Objectives：The purpose of this study was to investigate the changes of cognitive dysfunctions in patients with obsessivecompulsive disorder (OCD) over the two-year of pharmacological treatment. Methods：The thirty-three OCD patients and thirteen normal subjects were administered the neuropsychological tests and clinical evaluations twice (at the baseline and two-year). Results：In spite of the two-year treatment, the accuracy of delayed recall on the Rey-Osterrieth Complex Figure Tests (RCFT), the

Time-dependent formulations of the reactive scattering theory based on the wavepacket correlation functions with the Møller wavepackets for the electronically nonadiabatic reactions are presented. The calculations of state-to-state reactive probabilities for the quasi-Jahn-Teller scattering model system were performed. The conical intersection (CI) effects are investigated by comparing the results of the two-surface nonadiabatic calculations and the single surface adiabatic approximation. It was

This paper aims to find out which term was the official title of Joseon missions to Imperial China, and whether the widespread term yeonhangsa(燕行使), which is much more frequently used in Korea, China, Japan, and Taiwan after Fuma Susumu’s book is published, is a suitable to cover whole Joseon Missions to Ming and Qing dynasty. To clarify that, we investigated the government official records such as Veritable Records of the Joseon Dynasty and Journal of the Royal Secretariat. Our research finding

12093 Background: The National Comprehensive Cancer Network (NCCN) defines distress as an unpleasant, multidimensional experience that may interfere with patient behavior, emotions, and ability to cope with illness. Distress screening is a critical aspect of comprehensive cancer treatment, but the relationship between patient-reported distress and healthcare utilization remains unclear. We assessed this relationship in patients with advanced cancers historically associated with high utilization,

ABSTRACT: The aim of this study was to assess the appropriate time interval to identify the association between the fecal calprotectin (FC) test and endoscopic activity, and to evaluate whether the time interval affects the therapeutic plan adjustment in patients with ulcerative colitis (UC).This study included 103 patients who underwent FC tests and endoscopic examinations within the past three months. The FC test results classified cases into three groups as follows: moderate to severe (>200,

Low body temperature at 72 hours after TTM was independently associated with 1-year mortality.