Heyun Kim
Yonsei University · Biochemistry, Genetics and Molecular Biology
About the Lab
Professor Heyun Kim's research lab specializes in interdisciplinary studies at the intersection of molecular biology, structural biochemistry, and fashion sociology. The lab investigates the molecular mechanisms of protein-protein interactions, particularly focusing on scaffold proteins like syntenin-1 and their roles in cellular signaling and disease. Concurrently, the lab explores sociocultural dimensions of fashion, including naturalism in design, aging identity in sartorial expression, and the evolving tastes of middle-aged and senior consumers. These diverse research directions are united by a shared methodological rigor, employing structural biology techniques such as X-ray crystallography and NMR, alongside qualitative methodologies like Q methodology to analyze human perception and behavior in fashion and health contexts.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15The PDZ domain-containing scaffold protein, syntenin-1, binds to the transmembrane proteoglycan, syndecan-4, but the molecular mechanism/function of this interaction are unknown. Crystal structure analysis of syntenin-1/syndecan-4 cytoplasmic domains revealed that syntenin-1 forms a symmetrical pair of dimers anchored by a syndecan-4 dimer. The syndecan-4 cytoplasmic domain is a compact intertwined dimer with a symmetrical clamp shape and two antiparallel strands forming a cavity within the dime
The purpose of this study is to formulate a concept of naturalism in fashion and verify the design characteristics found in such designs via reviewing the concept of naturalism and its influence on dress making in different periods in history.The references from various academic fields including philosophy, literature and fine arts were used to examine how the naturalism was formulated over the years. This study was then to identify the naturalistic influences by closely examining various Wester
The purpose of this study is to classify fashion images of senior women who have emerged asinfluential customers in the fashion industry. Characteristics of fashion images of senior womenare identified by fashion style, preference color, and self-image. With the collected data, the Qgroup, consisting of Korean women who are in their 50s, was targeted using the Q methodology. The following factors were evaluated through in-depth interviews: fashion style, preference colorand self-image. The fashi
Purpose: The aim of this study was to investigate differences in language ability and emotional-behavioral problems according to the severity of social communication impairments (SCI) and restricted and repetitive behaviors (RRB) in children with autism spectrum disorders (ASD). Materials and Methods: We grouped 113 children with ASD aged 3–12 years according to the severity of SCI and RRB, and investigated language differences and emotional-behavioral problems among the severity groups. If diff
The purpose of this study is to define the tastes of middle-aged Korean men by analyzingtheir characteristics, such as self-image, and fashion style. This study was carried out by using theQ methodology for survey research. The results of this study are as follows;First, the self-images of middle-aged men were classified into ‘comfortable, calm, neat, and gentle,’‘realistic, active, sociable, and familiar,’ ‘sensible, emotional, romantic, and rational,’ ‘refined,emotional, luxurious, and sophist
The folding mechanism of typical proteins has been studied widely, while our understanding of the origin of the high stability of thermophilic proteins is still elusive. Of particular interest is how an atypical thermophilic protein with a novel fold maintains its structure and stability under extreme conditions. Folding-unfolding transitions of MTH1880, a thermophilic protein from Methanobacterium thermoautotrophicum, induced by heat, urea, and GdnHCl, were investigated using spectroscopic tech
이 연구는 차량 인포테인먼트 스크린 조작의 태스크 유형과 인터랙션 방식이 주행 효율성과 사용 경험 만족도에 미치는 영향을 밝히고자 하였다. 내비게이션과 음원 정보 검색의 두 가지 태스크와 세 가지 인터랙션 방식 즉, 터치 스크롤, 페이지 스크롤, 버튼 스크롤 방식을 선정하고 프로토타입을 제작하여 26명의 실험 참가자를 대상으로 모의 주행 실험을 진행하였다. 주행 효율성 차원에서 과업 수행 시간, 스크린 조작 횟수, 주행 에러 횟수를 관찰 측정하였고, 스크린 사용 만족도 차원에서 용이성, 매력도, 재사용 의도 인식을 평가하였다. 다변량 분산분석 결과 주행 효율성 차원에서 내비게이션 태스크에 비해 음원서비스 태스크 수행 시 주행 시간과 에러 횟수에서 효율성이 떨어졌다. 용이성, 매력도, 재사용 의도의 인식에서 인터랙션 방식의 주효과가 나타났으며, 부분적으로 태스크 유형과의 상호작용 효과가 나타났다. 특히, 터치 스크롤은 음원서비스 태스크에서 만족도가 높았고, 버튼 스크롤은 내비게이션 태
A newly developed cost-effective approach to prepare ^(15)N/^(13)C-labeled protein for NMR studies is presented. This method has been successfully applied to isotopically labeling of PTK6 SH2 domain and MTH 1880 protein. The production method generates cell density using a growing media containing ^(15)NH_(4)Cl, ^(12)C_(6)-D-glucose. Following a doubling time period for unlabeled metabolite exhaustion and then addition ^(13)C_(6)-D-glucose into a M9 growing media, the cells are induced. Our resu
목적: 신생아의 체중은 산모와 신생아의 주산기 합병증과 이환율에 큰 영향을 미치는 인자이다. 본 연구는 산모의 체중증가 및 임신 분기별 Body Mass Index (BMI)증가가 신생아의 체중에 미치는 영향을 알아보고자 하였다. 연구 방법: 2004년 3월부터 2004년 6월까지 본원에서 분만한 산모 73명을 대상으로 하였다. 임신중 체중증가 및 BMI증가를 산출하여 신생아 체중과의 관계를 통계분석하였다. 결과: 키 1.6 m인 산모가 임신 기간 전체 동안 12.5 kg의 체중 증가를 보이는 것을 표준으로 삼았다. 이를 Body mass index (BMI)로 환산하여 임신기간 전체의 BMI의 증가가 4.88일 경우를 적정BMI증가군으로 분류하였다. 임신 각 분기별 BMI의 적정증가를 계산하여 적정BMI증가군과 과BMI증가군으로 분류하였다. 임신 1, 2분기의 BMI증가는 신생아 체중증가에 영향을 미치지 않았으나, 임신 3분기, 특히 32주 이후와 36주 이후의 BMI증가는 신생아
현대 소비자들은 좀더 감각적이고, 정서적 만족감을 제공하는 제품을 기대하고 있으며, 이에 감성공학이란 전문적인 지식들을 자동차 디자인에 응용할 필요성이 대두되게 된 것이다. 자동차의 경우 개성 있는 나만의 차를 갖고 싶어하는 욕구로 자동차를 꾸미는 데에 많은 투자를 하면서 휠 디자인이 중요시되고 있다. 이에 본 연구에서는 새로운 디자인 방향 모색으로 감성 공학적 분석 방법을 통하여, 소비자들의 자동차 휠 디자인에 대한 이미지를 파악하고, 소비자의 요구와 감성에 따른 자동차 휠 디자인을 분석하였다. 그 결과, ‘harmonious’, ‘fresh’와 ‘strong’의 이미지가 자동차 휠 디자인을 대표하며, ‘harmonious’ 이미지로는 스포크 타입, ‘fresh’의 이미지는 메쉬 타입, ‘strong’의 이미지는 디쉬 타입의 자동차 휠 디자인으로 나타났다. 따라서 자동차 휠의 디자인 개발에 소비자의 감성을 기반으로 한 감성 공학적 디자인 접근을 함으로써 소비자에게 만족시킬 수 있는
Purpose: To explore mental health interventions using online technologies for school teachers and identify characteristics and effects on teachers’ mental health improvement. Methods: The method of Arksey and O’Malley was referenced. Two researchers independently searched seven electronic databases. Eleven experimental studies of online mental health interventions for K-12 teachers were analyzed for publication information, intervention characteristics, and summaries of outcome evaluations. Resu
Syndesmos, which is co-localized with syndecan-4 cytoplasmic domain (Syn4cyto) in focal contacts, interacts with various cell adhesion adaptor proteins including Syn4cyto to control cell signaling. Syndesmos consists of 211 amino acids and it exists as a dimer (44kDa) in solution. Recently, we have determined the structure of syndesmos by x-ray crystallography, however, dynamics related to syndecan binding still remain elusive. In this report, we performed NMR experiments to acquire biochemical
Syndesmos, which is co-localized with syndecan-4 cytoplasmic domain (<TEX>$Syn4^{cyto}$</TEX>) in focal contacts, interacts with various cell adhesion adaptor proteins including <TEX>$Syn4^{cyto}$</TEX> to control cell signaling. Syndesmos consists of 211 amino acids and it exists as a dimer (44kDa) in solution. Recently, we have determined the structure of syndesmos by x-ray crystallography, however, dynamics related to syndecan binding still remain elusive. In this report, we performed NMR exp
Research Areas
Dive deeper into Heyun Kim's research on Nubint
Open this lab's papers in the app to read with AI, summarize, and cite in your writing.