Hye-Jin Lee

STUDY QUESTION: Are there any novel genetic markers of susceptibility to polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: We identified a novel susceptibility locus on chromosome 8q24.2 and several moderately associated loci for PCOS in Korean women. WHAT IS KNOWN ALREADY: PCOS is a highly complex disorder with significant contributions from both genetic and environmental factors. Previous genome-wide association studies (GWAS) in the Han Chinese population identified several risk loci for PCOS

BACKGROUND/OBJECTIVES: The prevalence of obesity has markedly increased and is closely related to insulin resistance. Although lifestyle and genetic predisposition are significant factors influencing the pathophysiology within the body, endocrine-disrupting chemicals (EDCs) are also important triggers of metabolic disturbance. We investigated the relationship between exposure to EDCs and insulin resistance and obesity in healthy, reproductive-aged women. SUBJECTS/METHODS: This cross-sectional an

The BMI showed a U-shaped association with overall mortality, where slightly obese subjects showed the lowest rate of mortality. The CVE exhibited a linear association with the BMI, where the lowest risk was observed for normal weight subjects in a general Korean population.

Polycystic ovary syndrome (PCOS) is a highly complex reproductive metabolic disorder and women with PCOS have high prevalence of non-alcoholic fatty liver disease (NAFLD). Despite both hyperandrogenism and insulin resistance are common pathophysiologies in NAFLD and PCOS, this association is still controversial. Therefore, the aim of this study is to evaluate the relationship between hyperandrogenism and NAFLD in females diagnosed with PCOS. We recruited 667 women diagnosed with PCOS and 289 wom

고안드로겐혈증과 배란이상이 특징인 다낭난소증후군 (polycystic ovary syndrome, PCOS)은 가임여성의 5~10% 에서 발생하는 흔한 내분비 질환이며 여성 불임의 가장 흔한 원인 중 하나이다. PCOS의 병인은 아직 정확하게 밝혀져 있 지 않으며 생식샘자극호르몬분비호르몬 분비체계 이상, 부신 의 안드로겐 생산 이상, 난소자체의 안드로겐 합성의 이상, 인슐린저항성 등 여러 가지 가설이 제기되어 있으나[1~3] 이 들 중 어느 한 가지 병인으로 PCOS의 다양한 특징을 설명 할 수 없다. PCOS는 흔히 시상하부-뇌하수체-성선축이 성 숙하는 청소년기 동안에 임상적으로 발현된다. 그러나 최근 보고에 의하면 태생기에 안드로겐을 투여한 어미에서 출생 한 암컷 Rhesus monkey는 고안드로겐증, 배란장애, 다낭난 소 등 PCOS의 임상 특징과 내장지방 증가나 당대사 이상 등의 대사 이상이 동반되는 것이 관찰되어 PCOS가 발달 초 기, 출생 전 자궁 내 발달 단계에서 이

Serum miRNA-6767-5p may be a novel candidate as a molecular biomarker in the diagnosis of PCOS and may participate in the development of the metabolic and reproductive traits of PCOS.

Women with PCOS and normal glucose tolerance showed higher IR than controls matched for age, BMI, and β-cell function. β-cell function was increased in women with PCOS when compared to the matched controls, but not when the lean subjects were compared to the matched controls separately. Therefore, early evaluation of IR in women with PCOS and normal glucose tolerance may be needed.

Abstract Polycystic ovary syndrome (PCOS) is a highly complex disorder influenced by genetic and environmental factors. Previous genome-wide association studies (GWAS) on Han Chinese, Korean, and European populations identified multiple PCOS-susceptible loci; however, only a few studies reported the association of susceptibility genes with disease phenotypic traits. This cross-sectional study aimed to investigate the association between PCOS susceptibility genes from GWAS and disease-related cli

이 연구는 서울시 공립 초등학교와 중학교의 학교회계 결산자료를 기초로 단위 학교재정의 공평성을 측정하고 학부모와 학교가 소재한 자치구의 재정능력이 학생 1인당 교육비와 어떠한 상관관계에 있는지를 분석하였다. 분석결과, 1) 학생 1인당 교육비 측면에서 볼 때 서울특별시 초등학교의 학생 1인당 평균 교육비 수준이 중학교의 학생 1인당 평균 교육비 수준보다 지역간 격차가 더 심한 것으로 나타났으며, 2) 단위학교 세입·세출 총액만을 기준으로 수평적 공평성을 측정했을 때 학생당 교육비는 지역 간에 공평하게 배분되고 있었다. 3) 그러나 세입․세출의 각 항목별로는 지역 간에 차이가 있었는데, 세입 항목 중에서는 목적사업비, 자체수입, 학교발전기금, 보조금 및 지원금 항목에서 차이가 나타났다. 특히 중학교의 수익자부담경비 중 현장학습비의 차이가 눈에 띄게 나타났다. 4) 지역 간 차이에 비해 동일 지역 내 단위학교 간 차이가 더 큰 것으로 나타났으며, 5) 학교발전기금과 학생 1인당 교육비와

BACKGROUND: Reduced skeletal muscle has been suggested as a potential risk factor for type 2 diabetes mellitus (T2DM). Serum creatinine is the primary metabolite of creatine in skeletal muscle. Therefore, low serum creatinine levels may be associated with an increased risk of T2DM. We aimed to evaluate the association between serum creatinine levels and the risk of T2DM in Korea. METHODS: We analyzed a total of 264,832 nondiabetic adults older than 40 years of age who had undergone a national he

PURPOSE: Approximately 50% to 70% of women with polycystic ovary syndrome (PCOS) have some degree of insulin resistance, and obesity is known to worsen insulin resistance. Many metabolic consequences of PCOS are similar to those of obesity; therefore, defining the cause of insulin resistance in women can be difficult. Our objective was to clarify the factors contributing to insulin resistance in PCOS. MATERIALS AND METHODS: We consecutively recruited 144 women with PCOS [age: 26±5 yr, body mass

BACKGROUND/OBJECTIVES: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by chronic anovulation, hyperandrogenism, polycystic ovary morphology (PCOM) and metabolic disturbances including insulin resistance and type 2 diabetes mellitus. Although insulin resistance could be associated with PCOM, recent studies have shown controversial results. The aim of this study was to determine the relationship between PCOM and insulin resistance. SUBJECTS/METHODS: This was a cross-sec