Hye Won Kim

We found that microbial composition differs between asHU and gout patients. The differential gut microbiota in asHU patients may protect against gout development, whereas that in gout patients may have a role in gout provocation. ULT in gout patients altered the gut microbiota, and may help alleviate gout pathology and mitigate gout progression.

SCOPE: We examined the effect of paternal folate deficiency on the folate content, the percentage of 5-methycytosine (percentage of 5-mC) in the total DNA, and the protein expression of insulin-like growth factor-2 (IGF-2) in the fetal whole brain. METHODS AND RESULTS: Rats were mated after males were fed a folic acid deficient (PD) or folic acid supplemented (PS) diet for 4 weeks, and fetuses were killed on day 20 of gestation. The folate content in the fetal liver was significantly lower in th

OBJECTIVES: To determine the differential expressions of nucleotide oligomerisation domain (NOD)-like receptors (NLRs) and to investigate their association with inflammatory responses in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS). METHODS: Gene expression and protein levels of various NLRs, including NOD1, NOD2, NLRP1, NLRP3, NLRP12, NLRX1, and NLRC3, were determined in FLS and synovial tissues from patients with RA and patients with osteoarthritis (OA) using quantitative real-

DN at 72 h after bacteraemia may be valuable to assess the prognosis of patients with bacteraemia.

BACKGROUND: Sepsis is a syndrome that results in high morbidity and mortality. We investigated the delta neutrophil index (DN) as a predictive marker of early mortality in patients with gram-negative bacteremia. MATERIALS AND METHODS: We conducted a retrospective study at a tertiary referral hospital in South Korea from November 2010 to March 2011. The DN was measured at onset of bacteremia and 24 hours and 72 hours later. The DN was calculated using an automatic hematology analyzer. Factors ass

The implementation of a designated pharmacist-led medication reconciliation service had a positive clinical and economic impact in our hospitalist unit.

We investigated the effect of paternal folate status on folate content and expression of the folate transporter folate receptor α (FRα) in rat placental tissues. Rats were mated after males were fed a diet containing 0 mg of folic acid/kg of diet (paternal folate-deficient, PD) or 8 mg folic acid/kg of diet (paternal folate-supplemented, PS) for 4 weeks. At 20 days of gestation, the litter size, placental weight, and fetal weight were measured, and placental folate content (n = 8/group) and expr

Instances of tuberculosis were treated successfully in our AS patients, even when given concomitantly with TNF inhibitors. We suggest that early resumption of TNF inhibitors in AS patients could be safe under effective coverage of tuberculosis.

최근 미세먼지의 심각성에 대한 인식이 높아지면서 서울시는 미세먼지 비상저감조치의 일환으로 시민참여형 차량 2부제를 추진하는 한편, 실효성을 제고하기 위한 정책수단으로서 대중교통 무료 운행 정책을 도입하였다. 그러나 이는 하루 50억 원에 이르는 비용에 비해 미세먼지 저감효과가 크지 않다는 비판 속에서 시행 두 달 만에 중단되었다. 그렇다면 미세먼지의 심각성에 대한 국민적인 공감대에도 불구하고 미세먼지 저감을 위한 서울시의 대중교통 무료 운행 정책은 왜 실패하였는가? 본 연구는 해당 사례를 평가하기 위한 이론적 분석틀로서 Moore(1995)의 정치적 관리 전략을 활용하였다. 수도권의 광역교통체계를 고려할 때 서울시의 대중교통 무료 운행 정책이 성공하기 위해서는 경기도와 인천시의 협력이 필수적이다. 그러나 미세먼지 저감효과와 정책비용에 대한 정확한 정책분석이 이루어지지 않아 경기도 및 인천시와의 협상에서 대중교통 무료 운행 정책에 대한 지지를 확보하는 데 실패하였다. 한편, 서울시는

대중교통전용지구는 교통수요관리와 상권 활성화를 통해 도시의 지속가능성을 제고할 수 있으나 승용차 통행을 제한해 사업을 추진하려는 정부당국과 지역주민 간 갈등이 첨예하여 시행이 어려운 사업이다. 그러나 신촌 연세로 대중교통전용지구의 경우 사업추진과정과 효과 모두 성공적이라고 평가된다. 그렇다면 연세로 대중교통전용지구의 성공적 도입은 어떻게 설명할 수 있는가? 이와 관련하여 본 연구는 Kingdon(2011)의 다중흐름모형과 Moore(1995)의정치적 관리를 결합한 분석틀을 활용하였다. 다중흐름모형은 정책이 채택되는 환경적 맥락을, 정치적 관리 전략은 이러한 맥락 속에서 정책을 성공적으로 추진하기 위한 구체적인 실천전략을 제시한다. 분석 결과 연세로의 교통정체와상권 침체를 해결하기 위해 ‘차 없는 거리’ 등의 대안이 존재했으나 박원순 서울시장이 당선되면서 정책의 창이 열리고 대중교통전용지구라는 정책대안에 대한 논의가 본격화되었다. 서대문구는 개방적 의사결정, 논리적인 협상, 공적숙의,

BACKGROUND: Although bicarbonate has traditionally been used to treat patients with rhabdomyolysis at high risk of acute kidney injury (AKI), it is unclear whether this is beneficial. This study compared bicarbonate therapy to non-bicarbonate therapy for the prevention of AKI and mortality in rhabdomyolysis patients. METHODS: In a propensity score-matched cohort study, patients with a creatine kinase (CK) level of >1,000 U/L during hospitalization were divided into bicarbonate and non-bicarbonat

Taken together, in Korean patients with GPA, the granulomatous form was predominant and associated with a younger age at diagnosis and a lower frequency of renal involvement than the vasculitic form. ANCA positivity was found in 68.9 % and associated with renal involvement and higher mortality.