Hye-young Shin
Seoul National University · Neuroscience
About the Lab
Professor Hye-young Shin's research lab investigates the neural mechanisms underlying perception, sensory inference, and cortical dynamics with a focus on beta oscillations, transient neural events, and the role of specific inhibitory circuits in sensory processing. Using a multidisciplinary approach combining human MEG, mouse in vivo imaging (two-photon calcium imaging), Neuropixels recordings, and biophysical modeling, the lab explores how sparse, specialized neurons—particularly 'IC-encoders'—mediate perceptual inference in ambiguous conditions. A central theme is understanding how transient high-power beta events and cortical inhibition shape perception, attention, and behavior at both systems and cellular levels. The lab also examines the functional diversity of inhibitory interneurons in regulating cortical computation and oscillatory dynamics.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Beta oscillations (15-29Hz) are among the most prominent signatures of brain activity. Beta power is predictive of healthy and abnormal behaviors, including perception, attention and motor action. In non-averaged signals, beta can emerge as transient high-power 'events'. As such, functionally relevant differences in averaged power across time and trials can reflect changes in event number, power, duration, and/or frequency span. We show that functionally relevant differences in averaged beta pow
Transient neocortical events with high spectral power in the 15-29 Hz beta band are among the most reliable predictors of sensory perception. Prestimulus beta event rates in primary somatosensory cortex correlate with sensory suppression, most effectively 100-300 ms before stimulus onset. However, the neural mechanisms underlying this perceptual association are unknown. We combined human magnetoencephalography (MEG) measurements with biophysical neural modeling to test potential cellular and cir
When sensory information is incomplete or ambiguous, the brain relies on prior expectations to infer perceptual objects. Despite the centrality of this process to perception, the neural mechanism of sensory inference is not known. Illusory contours (ICs) are key tools to study sensory inference because they contain edges or objects that are implied only by their spatial context. Using cellular resolution, mesoscale two-photon calcium imaging and multi-Neuropixels recordings in the mouse visual c
When sensory information is incomplete, the brain relies on prior expectations to infer perceptual objects. Despite the centrality of this process to perception, the neural mechanisms of sensory inference are not understood. Here we used illusory contours (ICs), multi-Neuropixels measurements, mesoscale two-photon (2p) calcium imaging and 2p holographic optogenetics in mice to reveal the neural codes and circuits of sensory inference. We discovered a specialized subset of neurons in primary visu
Abstract This chapter describes how distinct classes of cortical inhibitory interneurons (INs) mediate unique aspects of cortical computation. First, it details how INs can be classified into discrete cell types based on their morphology, cellular physiology, gene expression, and synaptic connectivity. Next, it discusses how different IN classes shape cortical dynamics through their control of excitation-inhibition balance, their role in generating neural oscillations, and their modulation by br
Abstract Beta frequency oscillations (15-29Hz) are among the most prominent signatures of brain activity. Beta power is predictive of many healthy and abnormal behaviors, including perception, attention and motor action. Recent evidence shows that in non-averaged signals, beta can emerge as transient high-power “events”. As such, functionally relevant differences in averaged power across time and trials can reflect accumulated changes in the number, power, duration, and/or frequency span of the
Across species, tasks and recording modalities, the rate of transient neocortical beta frequency (15-29Hz) events strongly predicts perceptual ability, providing fundamental mechanistic insight, with implications for tracking and manipulating brain dynamics.
Persistent gamma oscillations (30-55Hz) are hypothesized to temporally coordinate stimulus encoding, enabling perception. This prediction poses a conundrum: How can gamma serve as a template when the stimulus itself drives its mediators, presumably perturbing its maintenance? Specifically, fast-spiking interneurons (FS), a key gamma generator, can be highly sensory responsive. Further, the gamma-band local field potential (LFP) shows properties inconsistent with temporal coordination. Combining
With the increasing media representation of aging as negative and abnormal, anti-aging products and discourses are spreading to younger generations. This paper analyzes the anti-aging discourse in a fashion magazine targeted towards women in their 20s. It quantitatively analyzes the historical development of the antiaging industry and discourses from 1994 to 2014 in the magazine『Céci』. It also analyzes the patterns of signification associated with aging in the magazine through the use of critica
온라인 교육과 관련된 기존 선행 연구를 바탕으로 본 연구는 학습자가 학습 용이성과 학습과정에서 인지된 즐거움을 경험할 때 학습 자기효능감을 형성, 이를 통해 학습 만족이 향상될 수 있다는 점을 제안하였다. 기존 연구는 학습자의 동기부여에 주로 초점을 두었기에 학습 용이성과 인지된 즐거움이 지닌 다양한 교육적 혜택의 가능성을 간과한 측면이 있었다. 본 연구는 서울과 대구 지역의 대학생 165명을 대상으로 설문을 수집 및 분석하여, 학습 용이성과 인지된 즐거움이 학습자의 학습만족에 긍정적인 영향을 미친다는 점을 확인할 수 있었다. 또한, 학습 용이성과 인지된 즐거움이 학습 만족에 미치는 효과는 학습자의 학습 자기효능감에 의해 부분 매개되는 것으로 나타났다. 연구결과를 통해 본 연구가 수립한 가설의 논리적 흐름이 타당함을 확인할 수 있었으며 국내 대학이 온라인 교육의 효과성을 높이는데 필요한 새로운 관점을 제안하였다. 본 연구는 후속 연구를 위해 필요한 학문적, 실무적 기여도를 추가로 논
How neuronal populations construct robust representations of the sensory world despite neural variability remains unclear. Here, we show that trial-to-trial variability in mouse primary visual cortex follows a simple rule: for each stimulus, the mean and variance of spike counts across neurons show a highly stereotyped relationship, with a slope of 1 on a log-log scale. To test how this geometry of trial-to-trial variability affects sensory representations, we numerically manipulated the slope o
This paper examines the advertisements for mass-produced women's clothing, which appeared in the 1980s issues of the fashion magazine Wolganmeot. This study explores the communicative aspect of fashion advertisements of the 1980s as a platform for complex and dynamic interactions between fashion brands, female consumers, and the rapidly changing social, cultural, and economic conditions of the period. The research focuses on advertisements in the formal and character casual categories that targe
Research Areas
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