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Hyerim Lee

Korea University

About the Lab

Professor Hyerim Lee's research lab focuses on environmental and occupational health, particularly in identifying and mitigating health hazards from chemical exposures such as PHMG-Phosphate and HCFC-123. The lab conducts toxicological hazard assessments, establishes reference concentration values (RfCworker), and proposes domestic occupational exposure limits (OELs) to support regulatory frameworks under occupational safety laws. Additionally, the lab investigates molecular mechanisms in chronic inflammatory diseases, including the role of prostaglandin E2 and cytokines like IL-6, IL-8, and VEGF in nasal polyp-derived fibroblasts. A parallel research line explores cybersecurity in mobile technology, emphasizing privacy-preserving methods for detecting malicious Android applications using machine learning techniques.

occupational healthtoxicological risk assessmentcytokine signalingAndroid securityexposure limit

Research Overview

Papers
9
Total Citations
36
Papers (5y)
8
Primary Field

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
8total
2014
2018
2019
2022
2023
Citations per year (5y)
32total
20142018201920222023

Selected Papers

9
1
Article|23 citations·2014
Prostaglandin E2 Induces IL-6 and IL-8 Production by the EP Receptors/Akt/NF-κB Pathways in Nasal Polyp-Derived Fibroblasts
조정선, 한인혜, 이혜림, 이흥만

Purpose: Interleukin 6 (IL-6) and IL-8 participate in the pathogenesis of chronic rhinosinusitis with nasal polyps, and their levels are increased byprostaglandin E2 (PGE2) in different cell types. The purposes of this study were to determine whether PGE2 has any effect on the increase in the levelsof IL-6 and IL-8 in nasal polyp-derived fibroblasts (NPDFs) and subsequently investigate the possible mechanism of this effect. Methods: Differentconcentrations of PGE2 were used to stimulate NPDFs at

2
Article|4 citations·2019
PHMG-Phosphate의 직업적 유해성평가를 통한 노출기준 제안 연구
이혜림, 변상훈, 이권섭
http://www.jksoeh.org/

Objective: This study was performed to propose a domestic occupational exposure limit(OEL) following a health hazard assessment, calculation of a non-carcinogenicity reference concentration worker(RfCworker) value, and examination of international agencies' exposure limits. It also recommends legal management within the Occupational Safety and Health Act for PHMG- Phosphate(CAS No. 89697-78-9), It is a humidifier disinfectant that generated many lung injuries. Methods: We have investigated the r

3
Article|4 citations·2013
Effect of Prostaglandin E2 on Vascular Endothelial Growth Factor Production in Nasal Polyp Fibroblasts
한동열, 조정선, 문유미, 이혜림, 이흥만, 이병돈, 백병준

Purpose: Angiogenesis is involved in the pathogenesis of chronic rhinosinusitis with nasal polyps. We aimed to investigate the effects of prostaglandinE2 (PGE2) on vascular endothelial growth factor (VEGF) production, the role of E-prostanoid (EP) 4 receptors, and the signal transduction pathwaymediating VEGF production in nasal polyp-derived fibroblasts (NPDFs). Methods: Eight primary NPDF cultures were established from nasalpolyps, which were incubated with or without PGE2. Reverse transcripti

4
Article|3 citations·2014
안드로이드 모바일 단말기를 위한 효율적인 악성앱 감지법
이혜림, 장수희, 윤지원
http://society.kisti.re.kr/journal/kj_view.jsp?kj=JBBHCB&soc=kiisc

스마트폰 사용이 급증하였고 스마트폰에 탑재되는 OS 중 안드로이드가 차지하는 비중이 가장 높아졌다. 그러나 오픈소스로 제공되는 안드로이드의 특성이 악의적인 사용자들에게 유용하게 사용되어 스마트폰 사용자들의 프라이버시를위협하고 있다. 이 논문에서 우리는 안드로이드 앱에서 요구하는 권한 정보를 사용하여 효율적인 악성앱 감지법을 제안한다. 이를 위하여 주성분 분석과 kNN 분류자를 사용하였으며, 새로운 앱들의 특성들을 분류자에 실시간으로 반영하기 위한 incremental kNN 분류자를 제안한다. 또한 이 분류자들의 정확률을 측정하기 위하여 k-묶음 교차 검증법을사용하였다. 실험에 사용된 실제 악성앱 샘플을 얻기 위하여 Contagio에 요청하였으며 이를 이용하여 분류자의 정확률을 측정하였다.

5
Article|2 citations·2018
HCFC-123의 급성 독성간질환 발생 사례에 따른 노출기준 및 법 관리 필요성 권고
이권섭, 조지훈, 최보경, 이혜림, 변상훈
www.jksoeh.org

Objectives: This study was performed to propose a domestic occupational exposure limit(OEL) following a health hazard assessment, calculation of a non-carcinogenicity reference concentration worker(RfCworker) value, and examination of international agencies' exposure limits. It also recommends legal management within the Occupational Safety and Health Act for HCFC-123, which caused an acute hepatotoxicity incident. Methods: An acute hepatotoxicity incident due to the fire extinguishing agent HCF

6
Article|0 citations·2022
Results of a Survey on Diagnostic Procedures and Treatment Choices for Neuromyelitis Optica Spectrum Disorder in Korea: Beyond the Context of Current Clinical Guidelines
이혜림, 김수현, 석진명, 김병조, 김호진, 김병준
https://doi.org/10.3988/jcn.2022.18.2.207

Background and Purpose Neuromyelitis optica spectrum disorder (NMOSD) is a rare demyelinating disease of the central nervous system (CNS). We investigated the medical behaviors of experts in Korea when they are diagnosing and treating NMOSD. Methods An anonymous questionnaire on the diagnosis and treatment of NMOSD was distributed to experts in CNS demyelinating diseases. Results Most respondents used the 2015 diagnostic criteria for NMOSD and applied a cerebrospinal fluid examination, magnetic

7
Article|0 citations·2023
임상 추론: 양하지 근력 저하와 통증으로 방문한 68세 여자
유현지, 이혜림
https://doi.org/10.17340/jkna.2023.3.15
8
Article|0 citations·2019
The effects of a community-based walking program on walking ability and fall-related self-efficacy of chronic stroke patients
이준민, 문형훈, 이성기, 이혜림, 박윤진
Journal of exercise rehabilitation

The objectives of this study were to evaluate the effects of communi-ty-based walking training (CWT) on the walking ability and fall-related self-efficacy of chronic stroke patients and compare the effects of CWT to the conventional walking programs in stroke patients. Previous stud-ies focused on walking speed, walking endurance, and balance. How-ever, no studies have examined the changes in fall-related self-efficacy after CWT. In order to achieve purpose of this study, 45 chronic stroke patie

9
Article|0 citations·2019
A Case of Frey’s Syndrome Diagnosed and Followed Up Using the Quantitative Sudomotor Axon Reflex Test
김재환, 김민경, 김예은, 이혜림
https://doi.org/10.3988/jcn.2019.15.4.585

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