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Hyo-Seok Na

Seoul National University · Medicine

About the Lab

Professor Hyo-Seok Na's research lab specializes in perioperative medicine, with a focus on optimizing anesthetic techniques, reducing postoperative complications, and improving patient outcomes in surgical populations. The lab investigates the use of regional and general anesthesia, sedation strategies (including dexmedetomidine and propofol), and blood conservation methods such as iron supplementation and erythropoietin therapy in orthopedic and general surgery. Key research directions include minimizing postoperative pain, reducing opioid use, preventing complications like emergence agitation and pulmonary issues, and enhancing recovery through evidence-based anesthetic protocols.

anesthesiapostoperative painblood conservationsedationperioperative medicine

Research Overview

Papers
130
Total Citations
1,570
Papers (5y)
50
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
50total
2021
2022
2023
2024
2025
Citations per year (5y)
453total
20212022202320242025

Selected Papers

15
1
Article|97 citations·2010
Effects of intravenous iron combined with low‐dose recombinant human erythropoietin on transfusion requirements in iron‐deficient patients undergoing bilateral total knee replacement arthroplasty (CME)
Hyo‐Seok Na, Soon‐Young Shin, Jin‐Young Hwang, Young‐Tae Jeon, Chong‐Soo Kim, Sang‐Hwan Do
SJR Q2Transfusion

BACKGROUND: The authors examined the impact of parenteral iron and recombinant human erythropoietin-β (rHuEPO-β) administered in the bilateral total knee replacement arthroplasty (TKRA), on postoperative anemia and transfusion requirements in iron-deficient patients. STUDY DESIGN AND METHODS: A total of 108 iron-deficient patients were randomly assigned to two groups: Group C (control) or Group IE (200 mg of iron sucrose intravenously over 1 hr and 3000 IU of rHuEPO-β subcutaneously during the o

BiochemistryMedicine
2
Article|68 citations·2012
Emergence agitation in children undergoing adenotonsillectomy: a comparison of sevoflurane vs. sevoflurane‐remifentanil administration
Hyo‐Seok Na, In‐Ae Song, Jung‐Won Hwang, Sang-Hwan Do, Ah‐Young Oh
SJR Q2Acta Anaesthesiologica Scandinavica

BACKGROUND: Sevoflurane is widely used in paediatric anaesthesia but frequently causes emergence agitation (EA). This study evaluated whether limiting the sevoflurane concentration by combining remifentanil with sevoflurane reduced the incidence of EA. METHODS: Eighty-four preschool children scheduled for adenotonsillectomy were randomly assigned to either the remifentanil or sevoflurane group. In the remifentanil group, anaesthesia was induced with thiopental, rocuronium, and 1% sevoflurane. It

Anesthesiology and Pain MedicineMedicine
3
Article|64 citations·2018
Comparison of Intraoperative Sedation With Dexmedetomidine Versus Propofol on Acute Postoperative Pain in Total Knee Arthroplasty Under Spinal Anesthesia: A Randomized Trial
Hyun-Jung Shin, Sang-Hwan Do, Jae-Sung Lee, Tae Kyun Kim, Hyo‐Seok Na
SJR Q1Anesthesia & Analgesia

BACKGROUND: In patients undergoing total knee arthroplasty under spinal anesthesia, we compared the postoperative analgesic effect of intraoperative sedation with dexmedetomidine versus propofol. We hypothesized that sedation with dexmedetomidine would result in lower postoperative opioid analgesic consumption than with propofol. METHODS: Forty-eight patients were enrolled and randomly assigned to either a dexmedetomidine group (n = 24), which received a loading dose of 1 μg/kg dexmedetomidine o

Anesthesiology and Pain MedicineMedicine
4
Article|41 citations·2011
Dexmedetomidine is effective for monitored anesthesia care in outpatients undergoing cataract surgery
Hyo‐Seok Na, In‐Ae Song, Hong-Sik Park, Jung‐Won Hwang, Sang-Hwan Do, Chong-Soo Kim
SJR Q1Korean journal of anesthesiologyOA

Compared with the combined use of propofol and alfentanil, dexmedetomidine could be used appropriately for MAC in cataract surgery with better satisfaction from the patients and a more stable cardiovascular state.

Anesthesiology and Pain MedicineMedicine
5
Article|37 citations·2011
Intravenous patient-controlled analgesia to manage the postoperative pain in patients undergoing craniotomy
Hyo‐Seok Na, Sang-Bum An, Hee‐Pyoung Park, Young-Jin Lim, Jung‐Won Hwang, Young-Tae Jeon, Seong-Won Min
SJR Q1Korean journal of anesthesiologyOA

IV-PCA with fentanyl and ketorolac after craniotomy is more effective analgesic technique, without adverse events, than the intermittent administration of analgesics.

SurgeryMedicine
6
Article|30 citations·2018
Value of preoperative spirometry test in predicting postoperative pulmonary complications in high-risk patients after laparoscopic abdominal surgery
Tak Kyu Oh, In Sun Park, Eunjeong Ji, Hyo‐Seok Na
SJR Q1PLoS ONEOA

Whether preoperative spirometry in non-thoracic surgery can predict postoperative pulmonary complications (PPCs) is controversial. We investigated whether preoperative spirometry results can predict the occurrence of PPCs in patients who had undergone laparoscopic abdominal surgery. This retrospective observational study analyzed the records of patients who underwent inpatient laparoscopic gastric or colorectal cancer surgery at Seoul National University Bundang Hospital between January 2010 and

Cardiology and Cardiovascular MedicineMedicine
7
Article|25 citations·2018
Association of Preoperative Serum Chloride Levels With Mortality and Morbidity After Noncardiac Surgery: A Retrospective Cohort Study
Tak Kyu Oh, Sang-Hwan Do, Young-Tae Jeon, Jin‐Hee Kim, Hyo‐Seok Na, Jung‐Won Hwang
SJR Q1Anesthesia & Analgesia

BACKGROUND: Postoperative hyperchloremia is known to be related to increases in mortality and morbidity after surgery. However, the relationship between preoperative hyperchloremia and hypochloremia and postoperative mortality and morbidity is not well established. Our aim was to evaluate the relationship between preoperative hyperchloremia or hypochloremia, as assessed using preoperative serum chloride tests, and 90-day mortality and morbidity after noncardiac surgery. METHODS: In this retrospe

Critical Care and Intensive Care MedicineMedicine
8
Article|24 citations·2016
The genetics of isoflurane-induced developmental neurotoxicity
Hyo‐Seok Na, Nicole L. Brockway, Katherine R. Gentry, Elyce Opheim, Margaret M. Sedensky, Philip G. Morgan
SJR Q2Neurotoxicology and Teratology
Developmental NeuroscienceNeuroscience
9
Article|23 citations·2022
Total intravenous anesthesia induced and maintained by a combination of remimazolam and remifentanil without a neuromuscular blocking agent: a prospective, observational pilot study
Insun Park, Mincheul Cho, Sun Woo Nam, Jung‐Won Hwang, Sang-Hwan Do, Hyo‐Seok Na
SJR Q1BMC AnesthesiologyOA

BACKGROUND: A novel short-acting benzodiazepine, Remimazolam, has recently been approved for general anesthesia and sedation. Hence, we investigated the feasibility and safety of remimazolam during the induction and maintenance of general anesthesia without using a neuromuscular blocking agent (NMBA) in patients undergoing hysteroscopic surgery. METHODS: This prospective observational study included 38 patients undergoing hysteroscopic surgery. Remimazolam and remifentanil were the main anesthet

Anesthesiology and Pain MedicineMedicine
10
Article|20 citations·2018
Intraoperative Nefopam Reduces Acute Postoperative Pain after Laparoscopic Gastrectomy: a Prospective, Randomized Study
Hyo‐Seok Na, Ah‐Young Oh, Jung‐Hee Ryu, Bon‐Wook Koo, Sun Woo Nam, Jihoon Jo, Jae-Hee Park
SJR Q1Journal of Gastrointestinal Surgery
SurgeryMedicine
11
Article|19 citations·2018
Comparison of upper airway patency in patients with mild obstructive sleep apnea during dexmedetomidine or propofol sedation: a prospective, randomized, controlled trial
Hyun‐Jung Shin, Eun Young Kim, Jung‐Won Hwang, Sang-Hwan Do, Hyo‐Seok Na
SJR Q1BMC AnesthesiologyOA

Clinical trials.gov ( NCT02993718 ): Retrospectively registered.

Anesthesiology and Pain MedicineMedicine
12
Article|15 citations·2022
Ultrasound assessment of gastric volume in older adults after drinking carbohydrate-containing fluids: a prospective, nonrandomized, and noninferiority comparative study
Hyun‐Jung Shin, Bonwook Koo, Dongsik Lim, Hyo‐Seok Na
SJR Q1Canadian Journal of Anesthesia/Journal canadien d anesthésieOA
SurgeryMedicine
13
Article|14 citations·2023
The effect of intranasal dexmedetomidine administration on emergence agitation or delirium in pediatric patients after general anesthesia: A meta‐analysis of randomized controlled trials
Hyo‐Seok Na, Su Yeon Kim, Ji In Park, SoHyun Lee, Jung‐Won Hwang, Hyun‐Jung Shin
SJR Q2Pediatric Anesthesia

Abstract Background Emergence agitation or delirium can occur in pediatric patients after anesthesia. Dexmedetomidine is known to reduce the impairment of postoperative cognitive function. Aims This study aimed to identify the role of intranasal administration of dexmedetomidine in lowering the development of emergence agitation or emergence delirium in pediatric patients after general anesthesia. Methods Electronic databases, including PubMed, EMBASE, CENTRAL, Scopus, and Web of Science, were s

Critical Care and Intensive Care MedicineMedicine
14
Article|14 citations·2019
The effect of neuromuscular reversal agent on postoperative pain after laparoscopic gastric cancer surgery
Tak Kyu Oh, Eunjeong Ji, Hyo‐Seok Na
SJR Q3MedicineOA

Use of sugammadex for neuromuscular block reversal is associated with fewer postoperative complications than neostigmine; however, the effects on postoperative pain outcomes are largely unknown. In this retrospective study, we investigated the relationship between neuromuscular reversal agents and postoperative pain-related outcomes following laparoscopic gastric cancer surgery.We reviewed the electronic health records of patients who underwent laparoscopic gastric cancer surgery between January

SurgeryMedicine
15
Article|12 citations·2011
A double bending lightwand can provide more successful endotracheal intubation in patients with a short thyromental distance
Young-Tae Jeon, Young‐Jin Lim, Hyo‐Seok Na, Sangheon Park, Ah‐Young Oh, Jung‐Won Hwang, Sung‐Hee Han, Hee‐Pyoung Park
SJR Q1European Journal of Anaesthesiology

We conclude that the double bending lightwand is associated with a greater success rate of intubation in patients with an anticipated difficult airway because of a short thyromental distance.

Anesthesiology and Pain MedicineMedicine

Research Areas

SurgeryCritical Care and Intensive Care MedicineAnesthesiology and Pain MedicineEmergency Medical ServicesPulmonary and Respiratory MedicineCardiology and Cardiovascular Medicine

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