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Hyuk Soo Han

Seoul National University · Medicine

About the Lab

Professor Hyuk Soo Han's research lab specializes in orthopedic biomechanics and joint replacement surgery, with a primary focus on improving outcomes in total knee arthroplasty (TKA). The lab investigates implant design, component fixation, and surgical techniques to reduce complications such as aseptic loosening and periprosthetic fractures. Research also emphasizes patient-specific factors—like preoperative glycemic control and tibial alignment—impacting surgical success and long-term implant survival.

total knee arthroplastyimplant looseningperiprosthetic fracturetibial alignmentdiabetes and TKA

Research Overview

Papers
243
Total Citations
3,023
Papers (5y)
97
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
97total
2022
2023
2024
2025
2026
Citations per year (5y)
725total
20222023202420252026

Selected Papers

15
1
Article|168 citations·2007
High incidence of loosening of the femoral component in legacy posterior stabilised-flex total knee replacement
Hyuk‐Soo Han, Seung‐Baik Kang, Kang Sup Yoon
Journal of Bone and Joint Surgery - British VolumeOA

We have examined the results obtained with 72 NexGen legacy posterior stabilised-flex fixed total knee replacements in 47 patients implanted by a single surgeon between March 2003 and September 2004. Aseptic loosening of the femoral component was found in 27 (38%) of the replacements at a mean follow-up of 32 months (30 to 48) and 15 knees (21%) required revision at a mean of 23 months (11 to 45). We compared the radiologically-loose and revised knees with those which had remained well-fixed to

SurgeryMedicine
2
Article|163 citations·2008
Anterior Cruciate Ligament Reconstruction
Hyuk‐Soo Han, Sang Cheol Seong, Sahnghoon Lee, Myung Chul Lee
SJR Q1Clinical Orthopaedics and Related ResearchOA

Level III Therapeutic study.

SurgeryMedicine
3
Article|135 citations·2013
Relations between Long-term Glycemic Control and Postoperative Wound and Infectious Complications after Total Knee Arthroplasty in Type 2 Diabetics
Hyuk‐Soo Han, Seung‐Baik Kang
SJR Q1Clinics in Orthopedic SurgeryOA

BACKGROUND: The authors examined whether poor preoperative glucose control, as indicated by the hemoglobin A1c (HbA1c) level of more than 8%, is associated with postoperative wound and infectious complications in diabetic patients that have undergone total knee arthroplasty (TKA). METHODS: One hundred and sixty-seven TKAs performed in 115 patients with type 2 diabetes mellitus, from January 2001 through March 2007, were retrospectively reviewed. Logistic regression was used to identify the varia

Endocrinology, Diabetes and MetabolismMedicine
4
Article|77 citations·2022
Functional alignment with robotic‑arm assisted total knee arthroplasty demonstrated better patient‐reported outcomes than mechanical alignment with manual total knee arthroplasty
Byung Sun Choi, Sung Eun Kim, Myungho Yang, Du Hyun Ro, Hyuk‐Soo Han
SJR Q1Knee Surgery Sports Traumatology Arthroscopy

PURPOSE: Given the improved accuracy of robot-assisted surgery, robotic-arm assisted functionally aligned total knee arthroplasty (RFA-TKA) aims to preserve the native pre-arthritic knee biomechanics, to achieve balanced flexion-extension gaps. The purpose of this study was to compare the accuracy of the implant position and short-term clinical outcomes of patients who underwent RFA-TKA vs. mechanically aligned total knee arthroplasty with manual technique (MA-TKA). METHODS: A prospectively coll

SurgeryMedicine
5
Article|63 citations·2018
The use of bisphosphonates after joint arthroplasty is associated with lower implant revision rate
Du Hyun Ro, Heejin Jin, Jae Young Park, Myung Chul Lee, Sungho Won, Hyuk‐Soo Han
SJR Q1Knee Surgery Sports Traumatology Arthroscopy

PURPOSE: This study hypothesized that the use of bisphosphonates (BPs) after total joint arthroplasty (TJA) is associated with a lower implant revision rate. This study aimed (1) to investigate the association between BP use and the revision rate of TJA and (2) to determine the relationship between the medication period and the revision rate of TJA. METHODS: National Health Insurance Service data on surgeries, medications, diagnoses, and screenings of 50 million Koreans were reviewed. People who

OncologyMedicine
6
Article|56 citations·2018
Hypoxic condition enhances chondrogenesis in synovium-derived mesenchymal stem cells
Hyun Cheol Bae, Hee Jung Park, Sun Young Wang, Ha Ru Yang, Myung Chul Lee, Hyuk‐Soo Han
SJR Q1Biomaterials ResearchOA

BACKGROUND: The chondrogenic differentiation of mesenchymal stem cells (MSCs) is regulated by many factors, including oxygen tensions, growth factors, and cytokines. Evidences have suggested that low oxygen tension seems to be an important regulatory factor in the proliferation and chondrogenic differentiation in various MSCs. Recent studies report that synovium-derived mesenchymal stem cells (SDSCs) are a potential source of stem cells for the repair of articular cartilage defects. But, the eff

RheumatologyMedicine
7
Article|52 citations·2009
Retrograde Intramedullary Nailing for Periprosthetic Supracondylar Fractures of the Femur after Total Knee Arthroplasty
Hyuk‐Soo Han, Kyu-Won Oh, Seung‐Baik Kang
SJR Q1Clinics in Orthopedic SurgeryOA

BACKGROUND: Periprosthetic supracondylar fractures of the femur after total knee arthroplasty are not common but are usually difficult to treat due to the advanced age of patients and frequently accompanying osteoporosis. Retrograde intramedullary nailing can be effective in promoting healing of these fractures by providing sufficient stability, but the number of beneficiaries is small due to its limited applicability and the postoperative function has rarely been assessed. This study evaluated

SurgeryMedicine
8
Article|42 citations·2017
Large meniscus extrusion ratio is a poor prognostic factor of conservative treatment for medial meniscus posterior root tear
Yoon-Ho Kwak, Sahnghoon Lee, Myung Chul Lee, Hyuk‐Soo Han
SJR Q1Knee Surgery Sports Traumatology Arthroscopy

PURPOSE: The purpose of this study was to find a prognostic factor of medial meniscus posterior root tear (MMPRT) for surgical decision making. METHODS: Eighty-eight patients who were diagnosed as acute or subacute MMPRT without severe degeneration of the meniscus were treated conservatively for 3 months. Fifty-seven patients with MMPRT showed good response to conservative treatment (group 1), while the remaining 31 patients who failed to conservative treatment (group 2) received arthroscopic me

SurgeryMedicine
9
Article|36 citations·2018
Anterior cruciate ligament reconstruction with quadriceps tendon-patellar bone allograft: matched case control study
Yoon-Ho Kwak, Sahnghoon Lee, Myung Chul Lee, Hyuk‐Soo Han
SJR Q2BMC Musculoskeletal DisordersOA

BACKGROUND: Quadriceps tendon-patellar bone (QTPB) autograft is an excellent graft option with good clinical outcome. Use of QTPB autografts have increased because they minimize donor-site morbidity including anterior knee pain, while providing adequate mechanical strength. Although, there were many clinical results about allografts that used in anterior cruciate ligament (ACL) reconstruction, it have never been reported about the clinical outcome of ACL reconstruction with QTPB allograft. The p

SurgeryMedicine
10
Article|32 citations·2019
Femoral joint line restoration is a major determinant of postoperative range of motion in revision total knee arthroplasty
Hyuk‐Soo Han, Cheol Hwan Yu, Nari Shin, Sungho Won, Myung Chul Lee
SJR Q1Knee Surgery Sports Traumatology Arthroscopy

PURPOSE: The purpose of this study was to comprehensively analyze the effects of femoral or tibial joint line elevation and patella height change on the clinical results after revision total knee arthroplasty (RTKA) and to determine which one is the significant factor that should be restored. METHODS: One hundred and sixty-six RTKA cases (144 patients) with a minimum 2-year follow-up were retrospectively analyzed. Demographic, operative, and clinical data were collected. Tibial and femoral joint

SurgeryMedicine
11
Article|31 citations·2003
Validation of a Functional Evaluation System in Patients With Musculoskeletal Tumors
Sang Hoon Lee, Dong Joon Kim, Joo Han Oh, Hyuk‐Soo Han, Kwang Hyun Yoo, Han‐Soo Kim
SJR Q1Clinical Orthopaedics and Related Research

The validity and reliability of the Musculoskeletal Tumor Society functional evaluation system were evaluated using the Nottingham Health Profile, the Short Form-36, and the EuroQol protocol to measure the quality of life of patients with malignant musculoskeletal tumors. Forty-nine patients were assessed and osteosarcoma around the knee was the most common type of tumor. Prosthetic reconstructions had been done in 55.1% of patients. In a content validity analysis, neither social nor psychologic

Pulmonary and Respiratory MedicineMedicine
12
Article|28 citations·2018
Efficacy of antifungal-impregnated cement spacer against chronic fungal periprosthetic joint infections after total knee arthroplasty
Jong-Keun Kim, Do-Yoon Lee, Dong‐Wan Kang, Du Hyun Ro, Myung Chul Lee, Hyuk‐Soo Han
SJR Q2The Knee
Infectious DiseasesMedicine
13
Article|27 citations·2017
Preservation of remnant with poor synovial coverage has no beneficial effect over remnant sacrifice in anterior cruciate ligament reconstruction
Bo Hyun Kim, Joong Il Kim, O-Sung Lee, Ki Woung Lee, Myung Chul Lee, Hyuk‐Soo Han
SJR Q1Knee Surgery Sports Traumatology Arthroscopy

III.

SurgeryMedicine
14
Article|27 citations·2012
Brief Followup Report: Does High-flexion Total Knee Arthroplasty Allow Deep Flexion Safely in Asian Patients?
Hyuk‐Soo Han, Seung‐Baik Kang
SJR Q1Clinical Orthopaedics and Related Research

Overall midterm high-flexion TKA survival in our Asian cohort was lower than that of conventional and other high-flexion designs. This unusually high rate of femoral component loosening was associated with postoperative high-flexion activities.

SurgeryMedicine
15
Article|26 citations·2010
Changes in chondrogenic phenotype and gene expression profiles associated with the in vitro expansion of human synovium‐derived cells
Hyuk‐Soo Han, Sahnghoon Lee, Ji Hyun Kim, Sang Cheol Seong, Myung Chul Lee
SJR Q1Journal of Orthopaedic Research®OA

We undertook this study to characterize changes in the proliferative capacities, chondrogenic phenotypes, and gene expression profiles of human synovium-derived progenitor cells from osteoarthritic patients during in vitro expansion. Cells isolated from osteoarthritic synovia were cultured, and growth rates during serial passages were evaluated. Surface molecule expressions were determined by flow cytometry and cytogenetic analyses were performed. After chondrogenic differentiation in cell pelle

RheumatologyMedicine

Research Areas

SurgeryRheumatologyBiomedical EngineeringBiochemistryPulmonary and Respiratory MedicineInformation Systems

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