Hyun Sook Kwon
Kyung Hee University · Biochemistry, Genetics and Molecular Biology
About the Lab
Professor Hyun Sook Kwon's research lab specializes in natural product chemistry, with a focus on the isolation, structural elucidation, and bioactivity evaluation of bioactive compounds from medicinal plants and fungi. The lab investigates coumarins, lignans, phenylpropanoids, and other phytochemicals for their potential anti-cancer, anti-oxidant, and enzyme-inhibitory activities. A key emphasis is placed on developing culturally and linguistically appropriate educational materials for Arabic-speaking learners of Korean, particularly in teaching Hangul script and pronunciation. The research integrates phytochemistry with pharmacological screening and educational innovation.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Two new coumarin derivatives were isolated together with three known coumarins, artelin (3), isofraxidin (4), and scoploetin (5) from the bark of Ailanthus altissima (Simaroubaceae). New coumarin derivatives were elucidated as terpenylated coumarins, named altissimacoumarin A (1) and altissimacoumarin B (2), respectively. Trans-Configuration of between C-2' and C-9' in compound (1) was clearly confirmed by NOESY experiments.
Osteosarcoma, which has poor prognosis after metastasis, is the most common type of bone cancer in children and adolescents. Therefore, plant-derived bioactive compounds are being actively developed for cancer therapy. Artemisia apiacea Hance ex Walp. is a traditional medicinal plant native to Eastern Asia, including China, Japan, and Korea. Vitexicarpin (Vitex), derived from A. apiacea, has demonstrated analgesic, anti-inflammatory, antitumour, and immunoregulatory properties; however, there ar
본 연구는 아랍어권 학습자를 가르친 한국어 교사와 한국어를 배우고 있는 아랍어권 학습자의 요구를 분석하고 그것을 바탕으로 아랍어권 학습자를 위한 ‘한국어 예비편 교재’ 개발을 하는 데 목적이 있다. 이에 교사와 학습자의 요구 분석 결과에 기초하여 아랍어권 학습자를 위한 한국어 예비편 교재 개발의 방향을 제언하고자 한다. 첫째, 한국어와 아랍어의 특징을 비교하면서 한국어를 소개한다. 둘째, 한글 자음자의 표기를 정확하게 이해하고 연습할 수 있는 활동을 많이 제시한다. 셋째, 오른쪽에서 왼쪽으로 쓰는 연습을 충분히 할 수 있게 한다. 넷째, 아랍어권 학습자들이 어려워하는 한국어 발음은 아랍어 발음과 비교하며 자세하게 다룬다. 다섯째, 한국어의 발음 규칙을 가르친다. 여섯째, 한글을 제시할 때 자음자와 모음자를 몇 개씩 묶어서 제시한다. 일곱째, 한글 자음자를 제시할 때 조음 방법에 따라 제시한다. 여덟째, 한글 모음자를 제시할 때 세로형과 가로형 모음자로 나눠서 제시한다. 아홉째, 한글
Five phenylpropanoids (1-5), a benzofuran neolignan (6), two 8-O-4'-neolignans (7-8), and five tetrahydrofuran lignans (9-13) were isolated from a methanol extract of Myristica fragrans seeds. The structures of 1-13 were determined by 1Hand 13C-NMR spectroscopic data analyses and a comparison with the literature data. Compound 3 was isolated for the first time from this plant. All the isolated compounds were evaluated for their inhibitory activity against tyrosinase. Among them, safrole (1) show
본 연구에서는 천연물 유래 항산화 소재로서 흰색 느티만가닥버섯(Hypsizygus marmoreus)의 부위별 이용 가능성을 알아보기 위하여 흰색 느티만가닥버섯을 갓(pileus)과 대(stipe)로 분리하여 열수와 80% 에탄올에 침지한 다음 부위별 항산화 활성을 조사하였다. 흰색 느티만가닥버섯은 에탄올 추출물(갓 부위 923.47±0.18 mg GAE/100 g, 대 부위 324.05±0.03 mg GAE/100 g)에 비해 열수 추출물(갓 부위 1137.39±0.38 mg GAE/100 g, 대 부위 700.86±0.06 mg GAE/100 g)의 총 폴리페놀 함량이 높게 나타났고 대 부위보다는 갓 부위의 총 폴리페놀 함량이 높게 나타났다. DPPH 라디칼 소거 활성은 10 mg/ml의 농도에서 에탄올 추출물 갓 부위의 활성이 47.32±0.23%로 가장 높았으며 ABTS 라디칼 소거 활성도 10 mg/ml의 농도에서 에탄올 추출물
Engineering, Gyeongnam National University of Science and Technology, Jinju 660-758, Korea Department of Functional Crop, National Institute of Crop Science, RDA, Miryang 627-803, Korea Division of Chemical Biology & BioTechnology, Nanyang Technological University, Singapore 637551 Division of Applied Life Science, Gyeongsang National University, Jinju 660-701, Korea Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Korea. *E-mail: dsjang@khu.ac.kr
Aggregates of disease-causing proteins dysregulate cellular functions, thereby causing neuronal cell loss in diverse neurodegenerative diseases. Although many in vitro or in vivo studies of protein aggregate inhibitors have been performed, a therapeutic strategy to control aggregate toxicity has not been earnestly pursued, partly due to the limitations of available aggregate models. In this study, we established a tetracycline (Tet)-inducible nuclear aggregate (β23) expression model to screen po
We suggest that shinjulactone A may be an effective and safe drug candidate for atherosclerosis because it targets and inhibits both endothelial inflammation and the EndMT, without impairing NFκB-dependent innate immunity in macrophages.
To evaluate the impact of rapid temperature change at spring and the early summer seasons in climate change, we have investigated the physiological response and yield of onion in a greenhouse with thermostat control system.
Research Areas
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