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Hyung Woo Jang

Seoul National University · Medicine

About the Lab

Professor Hyung Woo Jang's research lab specializes in biomedical engineering and clinical translational research, focusing on cardiovascular interventions, anticoagulation management, and tissue engineering for cardiac prostheses. The lab develops advanced predictive models for warfarin dosing using machine learning, investigates tracheostomy techniques to improve pediatric airway management, and explores methods to reduce calcification in bioprosthetic heart valves through chemical modification of pericardial tissues. The lab also examines aortic remodeling in aging and the progression of tricuspid regurgitation in patients with mitral valve disease, aiming to enhance long-term outcomes in structural heart disease.

cardiac interventionswarfarin dosingtracheostomybioprosthetic valvesaortic remodeling

Research Overview

Papers
88
Total Citations
486
Papers (5y)
39
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
39total
2022
2023
2024
2025
2026
Citations per year (5y)
74total
20222023202420252026

Selected Papers

15
1
Article|36 citations·2014
Pediatric tracheostomy revisited: A nine‐year experience using horizontal intercartilaginous incision
Jae‐Jin Song, Ik Joon Choi, Hyun‐Ha Chang, Dong Wook Kim, Hyoung Woo Chang, Gyeong‐Hun Park, Min‐Su Kim, Myung Whun Sung, J. Hun Hah
SJR Q1The Laryngoscope

OBJECTIVES/HYPOTHESIS: To describe our tracheostomy procedure using a vertical skin incision and a horizontal intercartilaginous incision and to compare our postoperative results with those in the recent literature. STUDY DESIGN: Retrospective chart review and literature review. METHODS: One hundred eleven children underwent tracheostomy using a vertical skin incision and a horizontal intercartilaginous incision over a 9-year period. A retrospective chart review was undertaken with respect to th

Pulmonary and Respiratory MedicineMedicine
2
Article|35 citations·2021
Development of a system to support warfarin dose decisions using deep neural networks
Heemoon Lee, Hyun Joo Kim, Hyoung Woo Chang, Dong Jung Kim, Jonghoon Mo, Ji-Eon Kim
SJR Q1Scientific ReportsOA

The first aim of this study was to develop a prothrombin time international normalized ratio (PT INR) prediction model. The second aim was to develop a warfarin maintenance dose decision support system as a precise warfarin dosing platform. Data of 19,719 inpatients from three institutions was analyzed. The PT INR prediction algorithm included dense and recurrent neural networks, and was designed to predict the 5th-day PT INR from data of days 1-4. Data from patients in one hospital (n = 22,314)

PharmacologyPharmacology, Toxicology and Pharmaceutics
3
Article|33 citations·2020
Diameter and growth rate of the thoracic aorta—analysis based on serial computed tomography scans
Hyoung Woo Chang, Sue Hyun Kim, Arief Rakhman Hakim, Suryeun Chung, Dong Jung Kim, Jae Hang Lee, Jun Sung Kim, Cheong Hwan Lim, Kay‐Hyun Park
SJR Q2Journal of Thoracic DiseaseOA

The thoracic aorta dilated with aging and was larger in subjects with a larger body size. Sex differences in the gross aortic diameter might be related to differences in body size. The growth of the thoracic aorta was faster in younger subjects with a smaller indexed diameter.

Pulmonary and Respiratory MedicineMedicine
4
Article|30 citations·2017
Long-term results of annuloplasty in trivial-to-mild functional tricuspid regurgitation during mitral valve replacement: should we perform annuloplasty on the tricuspid valve or leave it alone?
Jae Woong Choi, Kyung Hwan Kim, Hyoung Woo Chang, Myoung‐jin Jang, Sue Hyun Kim, Sang Yoon Yeom, Ho Young Hwang
SJR Q1European Journal of Cardio-Thoracic Surgery

Patients with untreated trivial or mild functional TR accompanied by mitral valve disease can develop significant TR during follow-up. TV ring annuloplasty can be performed without complications and can be beneficial for patients with trivial or mild functional TR who are undergoing MVR.

Cardiology and Cardiovascular MedicineMedicine
5
Article|30 citations·2016
Tricuspid Valve Replacement vs. Repair in Severe Tricuspid Regurgitation
Hyoung Woo Chang, Dong Seop Jeong, Yang Hyun Cho, Kiick Sung, Wook Sung Kim, Young Tak Lee, Pyo Won Park
SJR Q1Circulation JournalOA

Compared with TVr, TVR had acceptable early and late outcomes in patients with severe TR. TVR can be considered as a valid option with acceptable clinical outcomes in patients who are not suitable candidates for TVr.

Cardiology and Cardiovascular MedicineMedicine
6
Article|23 citations·2011
Combined anti-calcification treatment of bovine pericardium with amino compounds and solvents
Hyoung Woo Chang, Sang–Hyoun Kim, Kyung Hwan Kim, Y. J. Kim
SJR Q2Interactive Cardiovascular and Thoracic SurgeryOA

The objective of this study was to evaluate the effect of treatment with amino compounds and solvents in vivo on calcifications of glutaraldehyde (GA)-fixed pericardium. Groups of bovine pericardium samples were fixed with 0.5% GA. We used urazole and glutamate to neutralize the free aldehyde and some solvents (ethanol with octanol or octanediol) to reduce the phospholipid content in the bovine pericardial tissue. Tensile strength and thermal stability were evaluated before implantation. Twelve

Pulmonary and Respiratory MedicineMedicine
7
Article|11 citations·2014
Role of mitral valve repair in infective endocarditis.
Hyoung Woo Chang, Kyung Hwan Kim, Ho Young Hwang, Jun Sung Kim
PubMed

BACKGROUND AND AIM OF THE STUDY: Mitral valve reconstruction (MVP) is currently the standard treatment for degenerative mitral regurgitation (MR). However, when MR is due to infective endocarditis (IE) the range of pathophysiology present often makes any repair challenging. Hence, the authors' clinical experience of MVP to treat MR caused by IE was analyzed. METHODS: Between September 2004 and March 2011, a total of 26 patients (20 males, six females) who had been diagnosed with MR due to IE (si

EpidemiologyMedicine
8
Article|9 citations·2019
Clopidogrel versus Ticagrelor for Secondary Prevention after Coronary Artery Bypass Grafting
Hyoung Woo Chang, Hee Jung Kim, Jae Suk Yoo, Dong Jin Kim, Kwang Ree Cho
SJR Q1Journal of Clinical MedicineOA

We sought to evaluate the outcomes of postoperative three-month dual antiplatelet therapy in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) following off-pump coronary artery bypass grafting (OPCAB) with exclusively arterial grafts. Between 2013–2016, dual antiplatelet therapy (DAPT) with either aspirin + clopidogrel (ASA + CPD group, n = 100) or aspirin + ticagrelor (ASA + TCG group, n = 169) was prescribed postoperatively in 269 NSTE-ACS patients after total arterial OPCAB.

Cardiology and Cardiovascular MedicineMedicine
9
Article|8 citations·2013
Five‐Year Experience With Mini‐Volume Priming in Infants ≤5 kg: Safety of Significantly Smaller Transfusion Volumes
Hyoung Woo Chang, Jinhae Nam, Jae‐Hee Cho, Jeongryul Lee, Yong Jin Kim, Woong‐Han Kim
SJR Q2Artificial Organs

Reducing the cardiopulmonary bypass (CPB) priming volume in congenital cardiac surgery is important because it is associated with fewer transfusions. This retrospective study was designed to compare safety and transfusion volumes between the mini-volume priming (MP) and conventional priming (CP) methods. Between 2007 and 2012, congenital heart surgery using CPB was performed on 480 infants (≤5 kg): the MP method was used in 331 infants (MP group, 69.0%), and the CP method was used in 149 infants

EpidemiologyMedicine
10
Article|7 citations·2019
Late clinical outcomes of aortic valve replacement with Carpentier-Edwards pericardial valves
Hyoung Woo Chang, Wook Sung Kim, Joonghyun Ahn, Keumhee C. Carrière, Dong Seop Jeong, Yang Hyun Cho, Kiick Sung, Pyo Won Park
SJR Q2Journal of Thoracic DiseaseOA

Although Magna use led to decreased aortic valve pressure gradients at follow-up, overall and event-free survival rates were significantly better with use of the Perimount valve. Additional and larger studies are needed to confirm these results.

Cardiology and Cardiovascular MedicineMedicine
11
Article|4 citations·2018
Lower versus upper leg saphenous vein composite grafts based on the left internal thoracic artery: A randomized study
Hyoung Woo Chang, Ho Young Hwang, Jeong‐Wook Seo, Ki‐Bong Kim
SJR Q1Journal of Thoracic and Cardiovascular SurgeryOA
SurgeryMedicine
12
Article|4 citations·2013
Relationship between morphologic features of myocardial tissue and left ventricular function in patients with aortic valve disease and left ventricular hypertrophy.
Hyoung Woo Chang, Kyung Hwan Kim, Jun Sung Kim, Kyung‐Hee Kim, Yong-Jin Kim
PubMed

BACKGROUND AND AIM OF THE STUDY: The study aim was to investigate the correlation of myocardial fibrosis with myocardial remodeling and clinical outcome of aortic valve replacement (AVR) in patients with aortic stenosis and left ventricular (LV) hypertrophy. METHODS: Between 2007 and 2010, a total of 43 patients (23 males, 20 females; mean age 65.5 +/- 10.6 years; range: 33-84 years) underwent AVR at the authors' institution. During surgery, specimens (10 mm3) were obtained from the LV outflow t

Cardiology and Cardiovascular MedicineMedicine
13
Article|3 citations·2009
The Dynamic and Histologic Changes of Variously Fixed Bovine Pericardiums Specimens after Mechanical Fatigue Stimuli
Hyoung Woo Chang, Yong-Jin Kim, Soo Hwan Kim, Ji Eun Park, Chun Soo Park, Woong‐Han Kim, Kyung Hwan Kim
The Korean Journal of Thoracic and Cardiovascular Surgery

− 148 − *서울대학교 의과대학 서울대학교병원 흉부외과학교실 Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine **서울대학교병원 임상의학 연구소, 바이오 이종장기개발사업단 Seoul National University Hospital Clinical Research Institute, Xenotransplantation Research Center †본 연구는 보건복지부 보건의료기술진흥사업의 지원에 의하여 이루어진 것임(과제고유번호: A040004-008). 논문접수일:2008년 10월 6일, 심사통과일:2009년 2월 3일 책임저자:김용진 (110-744) 서울시 종로구 연건동 28, 서울대학교어린이병원 흉부외과 (Tel) 02-2072-3638, (Fax) 02-745-1509, E-mail

SurgeryMedicine
14
Article|3 citations·2025
Analysis of Risk Factors for Heparin Resistance During Cardiac Surgery: Does Antithrombin Deficiency Cause Heparin Resistance?
Young‐In Kim, Sang Yoon Kim, Hyoung Woo Chang, Joon Chul Jung, Jae Hang Lee, Sanghon Park, Jun Sung Kim
SJR Q2Journal of Cardiothoracic and Vascular Anesthesia
SurgeryMedicine
15
Article|3 citations·2017
Replacement of calcified ascending aorta in patients undergoing aortic valve replacement
Hyoung Woo Chang, Dong Seop Jeong, Yang Hyun Cho, Kiick Sung, Wook-Sung Kim, Young Tak Lee, Pyo Won Park
SJR Q2Journal of Thoracic DiseaseOA

Surgical AVR with AAR in AS patients with calcified ascending aortas led to acceptable early and late outcomes. Although the applications for TAVI are growing, a surgical approach may be an alternative option for relatively younger patients with severely calcified aorta.

Cardiology and Cardiovascular MedicineMedicine

Research Areas

Pulmonary and Respiratory MedicineCardiology and Cardiovascular MedicineSurgeryEpidemiologyBiomedical EngineeringPublic Health, Environmental and Occupational Health

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