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Hyunhwan Seong

Sungkyunkwan University · Medicine

About the Lab

Professor Hyunhwan Seong's research lab specializes in urological oncology and minimally invasive surgical techniques, with a strong focus on upper tract urothelial carcinoma (UTUC) and renal cancer. The lab investigates prognostic biomarkers such as erythrocyte sedimentation rate (ESR) and neutrophil-lymphocyte ratio (NLR) to improve patient outcomes after radical nephroureterectomy. It also evaluates the impact of diagnostic and therapeutic interventions—like ureterorenoscopy and radiofrequency ablation—on oncological and renal functional outcomes in urological malignancies.

urothelial carcinomaradical nephroureterectomyprognostic biomarkersminimally invasive surgeryrenal cancer

Research Overview

Papers
281
Total Citations
3,019
Papers (5y)
83
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
83total
2022
2023
2024
2025
2026
Citations per year (5y)
250total
20222023202420252026

Selected Papers

15
1
Article|267 citations·2009
Generalized Channel Inversion Methods for Multiuser MIMO Systems
Hyun Hwan Sung, S.-R. Lee, I. Lee
SJR Q1IEEE Transactions on Communications

Block diagonalization (BD) is a well-known precoding method in multiuser multi-input multi-output (MIMO) broadcast channels. This scheme can be considered as a extension of the zero-forcing (ZF) channel inversion to the case where each receiver is equipped with multiple antennas. One of the limitation of the BD is that the sum rate does not grow linearly with the number of users and transmit antennas at low and medium signal-to-noise ratio regime, since the complete suppression of multi-user int

Electrical and Electronic EngineeringEngineering
2
Article|61 citations·2012
Comparison of percutaneous radiofrequency ablation and open partial nephrectomy for the treatment of size- and location-matched renal masses
Hyun Hwan Sung, Byung Kwan Park, Chan Kyo Kim, Han Yong Choi, Hyun Moo Lee
SJR Q1International Journal of Hyperthermia

For treating size- and location-matched RCCs, RFA is superior to OPN with respect to the preservation of renal function. Furthermore, RFA can achieve excellent mid-term outcomes that are equivalent to those of OPN.

Pulmonary and Respiratory MedicineMedicine
3
Article|57 citations·2011
A Comparison of Early Complications Between Open and Robot-Assisted Radical Cystectomy
Hyun Hwan Sung, Jayeon Ahn, Seong Il Seo, Seong Soo Jeon, Han Yong Choi, Hyun Moo Lee, Byong Chang Jeong
SJR Q1Journal of Endourology

PURPOSE: The aim of our study was to compare early complication rates between the robot-assisted radical cystectomy (RARC) and open radical cystectomy (ORC) using a standardized reporting system. PATIENTS AND METHODS: From September 2008 to March 2011, 35 and 104 patients underwent ORC and RARC, respectively. Demographics and perioperative and complication data on all patients were reviewed retrospectively and compared between the two groups. All complications were categorized using a modified C

SurgeryMedicine
4
Article|54 citations·2015
Diagnostic Ureterorenoscopy Is Associated with Increased Intravesical Recurrence following Radical Nephroureterectomy in Upper Tract Urothelial Carcinoma
Hyun Hwan Sung, Hwang Gyun Jeon, Deok Hyun Han, Byong Chang Jeong, Seong Il Seo, Hyun Moo Lee, Han Yong Choi, Seong Soo Jeon
SJR Q1PLoS ONEOA

Diagnostic ureterorenoscopy is powerful tool to confirm upper tract urothelial cancer (UTUC). However, URS and associated manipulation may be related to the risk of intravesical recurrence (IVR) following radical nephroureterectomy (RNU). We aimed to investigate whether preoperative ureterorenoscopy would increase IVR after RNU in patients with UTUC. We performed a retrospective analysis of 630 patients who had RNU with bladder cuff excision due to UTUC. Diagnostic URS was performed in 282 patie

SurgeryMedicine
5
Article|30 citations·2018
Incidences and oncological outcomes of urothelial carcinoma in kidney transplant recipients
Jiwoong Yu, Chung Un Lee, Minyong Kang, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Hyun Hwan Sung
SJR Q2Cancer Management and ResearchOA

Incidence of UC was much higher in KT recipients than the general population. Treatment outcomes for UC in KT recipients were not inferior to those of non-KT patients, except for the progression of bladder cancer. Special attention should be paid to screening and treatment of UC in KT recipients.

SurgeryMedicine
6
Article|29 citations·2014
Clinical significance of prognosis using the neutrophil–lymphocyte ratio and erythrocyte sedimentation rate in patients undergoing radical nephroureterectomy for upper urinary tract urothelial carcinoma
Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Han-Yong Choi, Hyun Moo Lee
SJR Q1British Journal of Urology

OBJECTIVES: To evaluate the clinical significance of preoperative erythrocyte sedimentation rate (ESR) and neutrophil-lymphocyte ratio (NLR) as prognostic factors in patients undergoing radical nephroureterectomy for upper tract urothelial carcinoma (UTUC). PATIENTS AND METHODS: A total of 410 patients were retrospectively reviewed. An elevated NLR was defined as ≥2.5 and a normal ESR was considered to be in the range of 0-22 mm/h in men and 0-27 mm/h in women. Patients were divided into three g

OncologyMedicine
7
Article|27 citations·2013
The role of intracavernosal injection therapy and the reasons of withdrawal from therapy in patients with erectile dysfunction in the era of PDE5 inhibitors
Hyun Hwan Sung, Joo-Hyun Ahn, J. J. Kim, Seol Ho Choo, Deok Hyun Han, Sung Won Lee
SJR Q1AndrologyOA

There has been little data regarding the role of intracavernosal injection (ICI) treatment, its discontinuation rate and the reasons of withdrawal in patients with erectile dysfunction (ED) in the era of phosphodiesterase type 5 (PDE5) inhibitors. The aim of this study was to investigate the rate of withdrawal and its associated reasons in patients undergoing ICI therapy. Patients who were prescribed with ICI treatment two times or more were included since the introduction of sildenafil in Korea

Psychiatry and Mental healthMedicine
8
Article|23 citations·2021
Comparison of oncologic and functional outcomes between radical nephroureterectomy and segmental ureterectomy for upper urinary tract urothelial carcinoma
Tae Heon Kim, Chung Un Lee, Minyong Kang, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Hyun Hwan Sung
SJR Q1Scientific ReportsOA

This study aims to compare oncologic and functional outcomes after radical nephroureterectomy (RNU) and segmental ureterectomy (SU) in patients with upper urinary tract urothelial carcinoma (UTUC). We retrospectively collected data on patients who underwent either RNU or SU of UTUC. Propensity score matching was performed among 394 cases to yield a final cohort of 40 RNU and 40 SU cases. Kaplan-Meier analysis and the log-rank test were used to compare overall survival (OS), cancer-specific survi

SurgeryMedicine
9
Article|21 citations·2022
Robotic Radical Nephroureterectomy with Bladder Cuff Excision for Upper Tract Urothelial Carcinoma: A Trend Analysis of Utilization and a Comparative Study
Hoyoung Bae, Jae Hoon Chung, Wan Song, Minyong Kang, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Hyun Hwan Sung
SJR Q1CancersOA

Purpose: To compare the perioperative outcomes and oncological results of open, laparoscopic, and robotic radical nephroureterectomy (RNU) in patients with upper tract urothelial carcinoma (UTUC) and to analyze trends in the utilization of RNU. Methods: From 2017 to 2020, the records of 61, 185, and 119 patients who underwent open, laparoscopic, and robotic RNU, respectively, were reviewed. Results: Baseline characteristics were not significantly different among the three groups. Robotic RNU has

SurgeryMedicine
10
Article|20 citations·2012
Seven years of experience with high‐intensity focused ultrasound for prostate cancer: Advantages and limitations
Hyun Hwan Sung, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Han-Yong Choi, Hyun Moo Lee
SJR Q1The Prostate

BACKGROUND: The aim of this study was to evaluate oncologic outcomes and adverse events for patients with prostate cancer after treatment by high-intensity focused ultrasound (HIFU). METHODS: Between February 2004 and August 2010, patients with prostate cancer who underwent HIFU treatment were reviewed about oncologic outcomes and complications. Biochemical recurrence (BCR) was defined as prostate-specific antigen (PSA) nadir plus 1.2 ng/ml. Kaplan-Meier analysis was performed to evaluate BCR- a

Pulmonary and Respiratory MedicineMedicine
11
Article|19 citations·2019
Transperitoneal radical nephroureterectomy is associated with worse disease progression than retroperitoneal radical nephroureterectomy in patients with upper urinary tract urothelial carcinoma
Tae Heon Kim, Yoon Seok Suh, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi, Hyun Hwan Sung
SJR Q1Scientific ReportsOA

This study aimed to compare the oncologic outcomes between retroperitoneal radical nephroureterectomy (rRNU) and transperitoneal radical nephroureterectomy (tRNU) for the treatment of patients with upper urinary tract urothelial carcinoma (UTUC). Medical records of 743 eligible patients who underwent rRNU or tRNU between 1995 and 2015 were reviewed retrospectively. Progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS) were compared according to the surgical a

SurgeryMedicine
12
Article|18 citations·2021
Phase II multi-center trial of optical coherence tomography as an adjunct to white light cystoscopy for intravesical real time imaging and staging of bladder cancer
Hyun Hwan Sung, Douglas S. Scherr, Joel W. Slaton, Hao Liu, Katy Ledford Feeny, Colleen A. Lingley-Papadopoulos, John Gearheart, Jason M. Zara, Seth P. Lerner
SJR Q1Urologic Oncology Seminars and Original Investigations
SurgeryMedicine
13
Article|18 citations·2018
Persistent Erectile Dysfunction after Discontinuation of 5-Alpha Reductase Inhibitor Therapy in Rats Depending on the Duration of Treatment
Hyun Hwan Sung, Jiwoong Yu, Su Jeong Kang, Mee Ree Chae, Insuk So, Jong Kwan Park, Sung Won Lee
SJR Q1The World Journal of Men s HealthOA

Our study showed that recovery from ED depended on the duration of medication, and administration of dutasteride for more than 8-weeks in rats could result in irreversible ED even after discontinuation of medication.

Psychiatry and Mental healthMedicine
14
Article|13 citations·2014
Increased expression of TRPC4 channels associated with erectile dysfunction in diabetes
Hyun Hwan Sung, Seol Ho Choo, Myoung-Hwan Ko, Su Jeong Kang, Mee Ree Chae, Sung Chul Kam, Deok Hyun Han, Insuk So, Sung Won Lee
SJR Q1Andrology

In recent reports, an association between altered TRPC channel function and the development of various diabetic complications has drawn the attention of many investigators. The aim of this study was to investigate the expression of TRPC4 channels of corpus smooth muscle (CSM) cells in diabetes, and to evaluate the association between erectile dysfunction (ED) and altered TRPC4 channel function. The expression of TRPC4 in the penile tissue of human, normal and diabetic rat was investigated using

Psychiatry and Mental healthMedicine
15
Article|12 citations·2021
Conditional Intravesical Recurrence-Free Survival Rate After Radical Nephroureterectomy With Bladder Cuff Excision for Upper Tract Urothelial Carcinoma
Jae Hoon Chung, Wan Song, Minyong Kang, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Hyun Hwan Sung
SJR Q2Frontiers in OncologyOA

BACKGROUND: To evaluate the conditional intravesical recurrence (IVR)-free (IVRF) survival rate in patients with upper tract urothelial carcinoma (UTUC) who had no history of bladder cancer and no concomitant bladder cancer. Hence, we aimed to analyze a relatively large number of patients with UTUC who underwent radical nephroureterectomy with bladder cuff excision (RNUx). METHODS: We retrospectively analyzed the data of 1,095 patients with UTUC who underwent RNUx. Their baseline characteristics

SurgeryMedicine

Research Areas

Pulmonary and Respiratory MedicineSurgeryUrologyPsychiatry and Mental healthMolecular BiologyRheumatology

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