Hyunkyu Cho

Infection with rapidly growing nontuberculous mycobacteria is emerging as a global health issue; however, key host factors remain elusive. Here, we investigated the characteristic immune profiles of peripheral blood mononuclear cells (PBMCs) from patients infected with Mycobacteroides abscessus subsp. abscessus (Mabc) and M. abscessus subsp. massiliense (Mmass). Using an integrated analysis of global mRNA and microRNA expression profiles, we found that several inflammatory cytokines/chemokines [

PURPOSE: The chronic obstructive pulmonary disease (COPD) assessment test (CAT) is widely used to assess the impact of COPD symptoms on health status. Whilst the CAT consists of eight different items, details on the distribution of each item are limited. This study aimed to investigate the distribution and clinical implication of each CAT item, stratified by CAT severity group, in stable COPD patients. PATIENTS AND METHODS: This was a cross-sectional study at a single referral hospital in South

TPO is a slowly progressing disease and is well managed with conservative therapies. Although TPO shows a distinctive pattern by bronchoscopy, it follows a benign clinical course.

Aim: Several studies have reported favorable outcomes of nonspecific interstitial pneumonia (NSIP); however, its prognosis and prognostic factors remain unclear. This study aimed to determine the outcomes of fibrotic NSIP and the prognostic factors for progression, relapse, and survival. Methods: In this retrospective study, we reviewed the clinical data of 204 patients diagnosed with fibrotic NSIP by surgical lung biopsy at Samsung Medical Center. The factors associated with survival and diseas

Little is known about causality and the pathological mechanism underlying the association of serum lactate with myocardial injury in patients with acute myocardial infarction (AMI). We evaluated data from 360 AMI patients undergoing percutaneous coronary intervention (PCI) using cardiovascular magnetic resonance imaging (CMR). Of these, 119 patients had serum lactate levels > 2.5 mmol/L on admission (high serum lactate group), whereas 241 patients had serum lactate levels ≤ 2.5 mmol/L (low se

Question answering(QA) can vastly improve the quality and effectiveness of knowledge acquisition on the Web. Web search provides a list of documents targeted based on the keywords coined by the users; users need to investigate further the documents to obtain the very knowledge they wanted. QA can come up with the knowledge itself ready to be conceived directly by the users. We present a framework for building QA systems on the open Web, based on semantic Web services(SWS). In our framework, natu

About 22% of the patients in the young critical group did not have an underlying disease or obesity, but the rate of obesity (BMI > 25 kg/m²) was high, with a fatality rate of 5.6%. The full vaccination rate was extremely low compared to the general population of the same age group, showing that non-vaccination has a grave impact on the progression of COVID-19 to a critical condition. The findings of this study highlight the need for measures to prevent critical progression of COVID-19, such as

Seasonal influences may not affect advanced myocardial injury in STEMI patients undergoing primary PCI.

This study aimed to investigate the diverse clinical manifestations and simple early biomarkers predicting mortality of COVID-19 patients admitted to the emergency department (ED). A total of 710 patients with COVID-19 were enrolled from 6,896 patients presenting to the ED between January 2022 and March 2022. During the study period, a total of 478 patients tested positive for COVID-19, among whom 222 (46.4%) presented with extrapulmonary manifestations of COVID-19; 49 (10.3%) patients displayed

Despite appropriate coronary revascularization, old age was associated with greater extent of myocardial injury in STEMI patients.

Bi<sub>2</sub>Te<sub>3</sub>-based alloys have been extensively studied as thermoelectric materials near room temperature. In this study, the electrical, thermal, and thermoelectric transport properties of a series of Co-doped <i>n</i>-type Cu<sub>0.008</sub>Bi<sub>2</sub>Te<sub>2.6</sub>Se<sub>0.4</sub> polycrystalline alloys (Cu<sub>0.008</sub>Bi<sub>2−x</sub>Co<sub>x</sub>Te

Question answering(QA) can vastly improve the quality and effectiveness of knowledge acquisition on the Web. Web search provides a list of documents targeted based on the keywords coined by the users; users need to investigate further the documents to obtain the very knowledge they wanted. QA can come up with the knowledge itself ready to be conceived directly by the users. We present a framework for building QA systems on the open Web, based on semantic Web services(SWS). In our framework, natu

INTRODUCTION: Despite curative surgery for lung cancer, 30% to 55% of patients experience recurrence or death, which highlights the importance of adjuvant treatment. Adjuvant osimertinib therapy effectively prolongs disease-free and overall survival in patients with lung cancer harboring common epidermal growth factor receptor (EGFR) mutations. To identify potential candidates for adjuvant osimertinib, it is crucial to understand the rates and identify risk factors of recurrence. METHODS: This m

Background . Distinct bacterial strains may affect the prognosis of patients with chronic respiratory diseases. However, little is known about the clinical significance of respiratory bacteria in patients with chronic pulmonary aspergillosis (CPA), a progressive and debilitating disease caused by Aspergillus spp. Objectives . This study aimed to analyze data obtained from CPA patients and their sputum or bronchial washing samples and investigate the prevalence and composition of respiratory bact