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Jae Seung Lee

Yonsei University · Medicine

About the Lab

Professor Jae Seung Lee's research lab specializes in clinical and translational studies focusing on abdominal and hepatobiliary diseases, with a strong emphasis on imaging-based diagnostics, interventional radiology, and molecular mechanisms underlying liver cancer and pulmonary complications. The lab investigates conditions such as nutcracker syndrome in pediatric hematuria, biliary intraductal papillary neoplasms, and hepatocellular carcinoma (HCC), particularly in relation to treatment response evaluation using advanced imaging criteria like mRECIST. Additionally, the lab explores the role of molecular pathways—such as AMPK signaling—in lung inflammation and emphysema, linking basic science with clinical outcomes. Their work bridges radiological diagnostics, oncology, and molecular pathophysiology to improve patient management and outcomes.

hepatocellular carcinomamRECISTnutcracker syndromepostoperative pulmonary complicationsAMPK signaling

Research Overview

Papers
443
Total Citations
5,591
Papers (5y)
87
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
87total
2022
2023
2024
2025
2026
Citations per year (5y)
482total
20222023202420252026

Selected Papers

15
1
Article|134 citations·2005
Factors affecting spontaneous resolution of hematuria in childhood nutcracker syndrome
Jae Il Shin, Jee Min Park, Soon Min Lee, Youn Ho Shin, Ji Hong Kim, Jae Seung Lee, Myung‐Joon Kim
SJR Q1Pediatric NephrologyOA
SurgeryMedicine
2
Article|133 citations·2006
Effect of renal Doppler ultrasound on the detection of nutcracker syndrome in children with hematuria
Jae Il Shin, Jee Min Park, Jae Seung Lee, Myung‐Joon Kim
SJR Q1European Journal of PediatricsOA

To assess the detection rate of nutcracker syndrome in children with isolated hematuria, renal Doppler ultrasound examinations were routinely performed on 216 consecutive children (176 microscopic hematuria and 40 gross hematuria). Renal Doppler ultrasound was also performed on 32 healthy normal children. The peak velocity (PV) was measured at the hilar portion of the left renal vein (LRV) and at the LRV between the aorta and the superior mesenteric artery. The PV at the aortomesenteric portion

SurgeryMedicine
3
Article|64 citations·2005
Can azathioprine and steroids alter the progression of severe Henoch-Schönlein nephritis in children?
Jae Il Shin, Jee Min Park, Youn Ho Shin, Ji Hong Kim, Jae Seung Lee, Pyung Kil Kim, Hyeon Joo Jeong
SJR Q1Pediatric NephrologyOA
Pulmonary and Respiratory MedicineMedicine
4
Article|63 citations·2005
Cyclosporin A therapy for severe Henoch-Schönlein nephritis with nephrotic syndrome
Jae Il Shin, Jee Min Park, Youn Ho Shin, Ji Hong Kim, Pyung Kil Kim, Jae Seung Lee, Hyeon Joo Jeong
SJR Q1Pediatric NephrologyOA
Pulmonary and Respiratory MedicineMedicine
5
Article|47 citations·2010
The clinicopathological features of biliary intraductal papillary neoplasms according to the location of tumors
Sung C. Choi, Jong Kyun Lee, Jong Kyun Lee, Jae Hong Jung, Jae Seung Lee, Jae Seung Lee, Kwang Hyuck Lee, Kyu Taek Lee, Poong‐Lyul Rhee, Kee‐Taek Jang, Seong Ho Choi, Jin Seok Heo
SJR Q1Journal of Gastroenterology and Hepatology

BACKGROUND AND AIM: In this study, we analyzed the clinical and pathological features of biliary intraductal papillary neoplasms (IPN-B) according to the location of the tumors. METHODS: A total of 55 patients with IPN-B were analyzed. We divided them into three groups: common bile duct (CBD), hilar, and intrahepatic duct (IHD) groups. The clinical and laboratory findings, cell types, depth of invasion, malignancy, existence of stones, lymph node metastasis, recurrence, and survival rate were an

SurgeryMedicine
6
Article|45 citations·2016
Pulmonary complications after abdominal surgery in patients with mild-to-moderate chronic obstructive pulmonary disease
Tae Hoon Kim, Jae Seung Lee, Sei Won Lee, Yeon‐Mok Oh
SJR Q1International Journal of COPDOA

Postoperative pulmonary complications (PPCs) are one of the most important causes of postoperative morbidity and mortality after abdominal surgery. Although chronic obstructive pulmonary disease (COPD) has been considered a risk factor for PPCs, it remains unclear whether mild-to-moderate COPD is a risk factor. This retrospective cohort study included 387 subjects who underwent abdominal surgery with general anesthesia in a tertiary referral hospital. PPCs included pneumonia, pulmonary edema, pu

Pulmonary and Respiratory MedicineMedicine
7
Article|44 citations·2015
Role of AMP-Activated Protein Kinase (AMPK) in Smoking-Induced Lung Inflammation and Emphysema
Jae Seung Lee, Sun Joo Park, You Sook Cho, Jin Won Huh, Yeon‐Mok Oh, Sang‐Do Lee
SJR Q2Tuberculosis & respiratory diseasesOA

Background: AMP-activated protein kinase (AMPK) not only functions as an intracellular energy sensor and regulator, but is also a general sensor of oxidative stress. Furthermore, there is recent evidence that it participates in limiting acute inflammatory reactions, apoptosis and cellular senescence. Thus, it may oppose the development of chronic obstructive pulmonary disease. Methods: To investigate the role of AMPK in cigarette smoke-induced lung inflammation and emphysema we first compared ci

Molecular BiologyBiochemistry, Genetics and Molecular Biology
8
Article|44 citations·2020
The Modified Response Evaluation Criteria in Solid Tumors (RECIST) Yield a More Accurate Prognoses Than the RECIST 1.1 in Hepatocellular Carcinoma Treated with Transarterial Radioembolization
Jae Seung Lee, Hong Jun Choi, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang‐Hyub Han, Song‐Ee Baek, Yong Eun Chung, Mi‐Suk Park, Myeong‐Jin Kim, Hyungjin Rhee
SJR Q1Gut and LiverOA

Response evaluations that use the mRECIST provide more accurate prognoses than those that use the RECIST 1.1 in HCC patients treated with TARE.

HepatologyMedicine
9
Article|39 citations·2019
A survey on transarterial chemoembolization refractoriness and a real-world treatment pattern for hepatocellular carcinoma in Korea
Jae Seung Lee, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Sang Hoon Ahn, Jin Sil Seong, Kwang‐Hyub Han, Do Young Kim
SJR Q1Clinical and Molecular HepatologyOA

Treatment of HCC is often based on the clinical judgment of clinicians because of the heterogeneity among individuals. Experts need to continue discussions on the standardization and sub-classification of HCC treatment guidelines in Korea.

HepatologyMedicine
10
Article|34 citations·2005
Factors affecting histological regression of crescentic Henoch–Schönlein nephritis in children
Jae Il Shin, Jee Min Park, Ji Hong Kim, Jae Seung Lee, Hyeon Joo Jeong
SJR Q1Pediatric NephrologyOA
Pulmonary and Respiratory MedicineMedicine
11
Article|33 citations·2006
Doppler ultrasonographic indices in diagnosing nutcracker syndrome in children
Jae Il Shin, Jee Min Park, Jae Seung Lee, Myung‐Joon Kim
SJR Q1Pediatric NephrologyOA
SurgeryMedicine
12
Article|31 citations·1997
Simplified Anatomic Method of Double-Eyelid Operation: Septodermal Fixation Technique
Jae Seung Lee, Weon-Jin Park, Myoung-Soo Shin, Chul Hong Song
SJR Q1Plastic & Reconstructive Surgery

Conventionally, it has been argued that the aponeurosis meets the orbital septum below the upper tarsal border in Orientals. However, we have shown that the aponeurosis fused with the orbital septum above the upper tarsal border in 502 patients, which contradicts the classic concept. In 457 patients there were distinct layers of fascia anterior to the orbital septum that originate from the septum and insert onto the pretarsal aponeurotic expansion. In Oriental eyelids, the preaponeurotic fat and

DermatologyMedicine
13
Article|27 citations·2021
Liver Stiffness-Based Risk Prediction Model for Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease
Jae Seung Lee, Dong Hyun Sinn, Soo Young Park, Hye Jung Shin, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Joo Hyun Oh, Jung Il Lee, Seung Up Kim
SJR Q1CancersOA

Non-alcoholic fatty liver disease (NAFLD) is associated with an increased hepatocellular carcinoma (HCC) risk. We established and validated a liver stiffness (LS)-based risk prediction model for HCC development in patients with NAFLD. A total of 2666 and 467 patients with NAFLD were recruited in the training and validation cohorts, respectively. NAFLD was defined as controlled attenuated parameter ≥238 dB/m by transient elastography. Over a median of 64.6 months, HCC developed in 22 (0.8%) subje

EpidemiologyMedicine
14
Article|26 citations·2020
Empirical Treatment With Carbapenem vs Third-generation Cephalosporin for Treatment of Spontaneous Bacterial Peritonitis
Sun Woong Kim, Jun Sik Yoon, Jun Yong Park, Yong Jin Jung, Jae Seung Lee, Jae Seung Lee, Ji‐Soo Song, Han Ah Lee, Yeon Seok Seo, Minjong Lee, Jin Myung Park, Dae Hee Choi
SJR Q1Clinical Gastroenterology and HepatologyOA
PharmacologyMedicine
15
letter|25 citations·2007
Follow-up and Treatment of Nutcracker Syndrome
Jae Il Shin, Seoung Yon Baek, Jae Seung Lee, Myung‐Joon Kim
SJR Q2Annals of Vascular SurgeryOA
SurgeryMedicine

Research Areas

Pulmonary and Respiratory MedicineEpidemiologySurgeryHepatologyNephrologyInternal Medicine

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