Jaemyung Lee
Yonsei University
About the Lab
Professor Jaemyung Lee's research lab specializes in biomedical materials and renal medicine, focusing on the development of functional hydrogels for clinical diagnostics and the pathophysiology of kidney-related disorders. Key research directions include designing colorimetric sensors for hazardous substances like hydrofluoric acid, investigating vascular access complications in hemodialysis patients, and exploring molecular mechanisms of nephrotoxicity in renal transplantation. The lab integrates materials science with clinical nephrology to address critical challenges in dialysis access, drug-induced kidney injury, and early detection of renal diseases.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
7Colorimetric HF-sensitive hydrogel beads were prepared using alginate hydrogel as a host matrix and apyrocatechol violet (PV)–titanium(IV) bis(ammonium lactato)dihydroxide (TALH) complex as a HFsensingdye. The PV–TALH complex dye was released into a HF solution from the host matrices andturned the transparent HF solution yellow. From the results of control experiments, this yellow color wasexclusively observed when the beads were exposed to HF. The color change allowed the detection of HFwith th
배 경 : 말기신부전 환자에서 발생하는 심남염은 부적절한 투석, 감염, 부갑상선 호르몬 이상, 결체조직질환, 혈소판 기능손상, 심근경색, 투석시 사용되는 항용고제나 약제 그리고 면역학적 요소로 인한 순환 면역 복합체 및 보체 등과 연관되어 나타날 수 있으며, 요독성 심낭영의 발생 빈도는 약 20% 정도로 말기신부전 환자의 유병률과 사망률을 높이는 중요한 합병증의 하나로 알려져 있다. 일반적으로 심낭염의 원인과 심낭삼출책의 정도는 치료에 대한 반응과 예후에도 차이가 있으며 심낭삼출액의 진단과 추적관찰에는 심초음파촬영이 유용한 것으로 알려져 있다. 이에 저자들은 정기적 혈액투석 중 요독성 심낭염의 소견을 보여 심초음파를 시행한 환자의 임상 양상을 알아보고자 하였다. 방 법 :심초음파 검사상 요독성 심낭염이 의심된 환자 35예의 진료기록을 검토하여 심남 삼출량의 정도에 따라 미세소량군과 중등-대량군으로 나누어 두 군간의 진단 당시의 검사결과 및 심출 정도에 따른 임상적 특징을 비교하였다.
Purpose: We designed this study to find out the risk factors affecting the patency rate after creation of an arteriovenous fistula (AVF) for hemodialysis. Methods: Between March 1997 and December 2001, a total of 397 AVF operations in 314 patients were performed by a single surgeon using the same surgical technique and principles. One hundred and forty cases (35.3%) were reoperations due to previous AVF failure. Artificial vessels (=PTFE, polytetrafluoroethylene) were used for the AVF in 39 case
The term of giant hydronephrosis in adults, is applied when the collecting system contains more than 1,000 mL of fluid. The commonest cause of asymptomatic giant hydronephrosis in early adult life is congenital ureteropelvic stenosis. Giant hydronephrosis in adults is uncommon and often clinically misdiagnosed, because clinical characteristics are vague and generalized symptom. We presented a giant hydronephrosis associated with ureter stricture on 31 years old male.
Dysfunction of vascular access remains a leading cause of morbidity in patients receiving maintenance hemodialysis, accounting for 10-25% of their hospitalization. The main cause of vascular access dysfunction is thrombosis which is related to venous stenosis. The pathogenetic mechanism of venous stenosis includes cytokines, coagulation factors, growth factors and adhesion molecules. Two such cytokines, monocyte chemoattractant protein-1(MCP-1) and interleukin-6(IL-6), are known to be important
목 적:현재 가장 널리 사용되는 면역억제제 중의 하나인 Cyclosporin A (CsA)가 신이식의 성적을 향상시켰으나 신독성으로 인해 이식신의 장기적인 생존율에는 영향을 미치지 못하고 있다. CsA에 의해 생성이 증가된 Transforming growth factor-β (TGF-β)와 Endothelin-1 (ET-1)이 주요한 신독성의 매개인자로 밝혀졌다. 최근 Azathioprine 대용으로 Mycophenolate mofetil (MMF)이 널리 사용되어 CsA와 MMF를 병합투여 시 면역억제기능이 상승하지만 CsA의 신독성을 매개하는 인자에 대한 연구는 없다. 이에 본 연구에서는 허혈-재관류 모델 백서에서 CsA와 MMF를 단독 또는 병합투여 시 CsA 신독성의 중요한 매개인자인 TGF-β1과 ET-1의 생성과 발현에 어떤 영향을 미치는지 알아보고자 하였다. 방 법:단일 신장 백서의 혈관경 (renal pedicle)을 30분간 클램프한 후 재관류하여 허혈-재관류 손상을
The association of malignancy with glomerulonephritis is well known. The most frequent observed renal lesions associated with malignancy are the membranous glomerulonephritis on carcinoma and minimal change nephrotic syndrome on Hodgkin's disease. Recently, IgA nephropathy associated with liver disease, connective tissue disease, gastrointestinal disease, dermatologic disease, hematologic disease and malignancy were reported. But the relationship between malignancy and IgA nephropathy is not cle
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