Jeong-Geun Lee
Yonsei University · Biochemistry, Genetics and Molecular Biology
About the Lab
Professor Jeong-Geun Lee's research lab focuses on cellular and molecular mechanisms underlying adipogenesis and obesity, with a particular emphasis on mechanobiology and hormonal regulation. The lab investigates how mechanical stimuli such as fluid shear stress and bioactive molecules like melatonin influence transcriptional regulation in preadipocytes, aiming to identify novel therapeutic targets for metabolic disorders. Additionally, the lab explores the role of extracellular mucus in feeding dynamics of marine protists, highlighting interdisciplinary interests in both biomedical and environmental microbiology. These studies integrate cell biology, biophysics, and translational research to address obesity and related diseases.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
9Noctiluca scintillans secrets mucus around its tentacle and feeds on the materials trapped in it. The food removal rates in the suspensions of Tetraselmis tetrathelle and Gymnodinium nagasakiense were calculated using a model for filter feeder which is based on the change in food level during the feeding experiment. The clearance rate by starved Noctiluca varied depending upon the food level and experimental duration. With T. tetrathelle, the rate decreased as the food level increased over 4×10⁵
FloWise flow diverter is safe and effective for the treatment of unruptured wide-neck aneurysms.
[This corrects the article DOI: 10.1371/journal.pone.0244102.].
Clinical Research Information Service Identifier: KCT0005660.
Adipocytes are the main constituent of adipose tissue. Understanding the molecular basis of adipogenesis is pivotal to finding the therapeutic targets for treatment of obesity. Melatonin is associated with obesity and its mechanism is currently under intensive investigation. The objective of this study was to investigate the effect of melatonin on adipogenesis in differentiating preadipocytes. 3T3-L1 preadipocytes were cultured in Dulbecco’s modified Eagle’s medium (DMEM) containing 5% calf seru
Adipocytes affect obesity through the regulation of lipid metabolism. Physical loading is an important regulator of fat tissue. There are ongoing in vitro studies inducing mechanotransduction on 3T3-L1 preadipocytes with mechanical stimulus in order to treat obesity by inhibiting adipogenesis and provoking cell death. In this study, our goal was to suggest a new therapy for obesity by investigating whether fluid shear stress (FSS) changes transcription factors on 3T3-L1 related with adipogenesis
Obesity is a worldwide disease caused by the excessive proliferation of adipocytes. Multiple factors, including melatonin and physical loading, are involved in the control of obesity. Melatonin has been shown to induce apoptosis on preadipocytes while physical loading such as fluid shear stress (FSS) affects the proliferation and differentiation of adipocytes. Here, we studied the combined effects of melatonin and FSS on 3T3-L1 preadipocytes. For physical loading, preadipocytes were stimulated w
You have accessJournal of UrologyBladder Cancer: Basic Research IV1 Apr 2014MP39-05 SYNERGISTIC ANTITUMOR EFFECT OF SAHA AND CISPLATIN IN CISPLATIN RESISTANT BLADDER CANCER CELL LINE Ha Rim Kook, Young Ju Lee, Jae Seung Yeon, Han Sol Lee, Choong Hee Noh, Kwang Mo Kim, Ki Beom Kim, Jung Keun Lee, Sangchul Lee, Seong Jin Jeong, Sung Kyu Hong, Seok-Soo Byun, Eunsik Lee, and Sang Eun Lee Ha Rim KookHa Rim Kook More articles by this author , Young Ju LeeYoung Ju Lee More articles by this author , Jae
Research Areas
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