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Jeong Hwa Lee

Seoul National University · Medicine

About the Lab

Professor Jeong Hwa Lee's research lab focuses on molecular and cellular mechanisms in cancer biology, particularly the role of key regulatory proteins such as TSG-6 and BAG3 in tumor progression and immune modulation. The lab investigates the tumor microenvironment, including immune cell activation and stromal interactions, using in vitro and in vivo models. Additionally, the lab explores endocrine and metabolic dysregulation in disease models, particularly in adrenal and thymic pathologies. A translational approach is applied to understand disease mechanisms and identify potential therapeutic targets in oncology and inflammatory disorders.

cancer biologytumor microenvironmentTSG-6BAG3inflammatory disease

Research Overview

Papers
178
Total Citations
928
Papers (5y)
38
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
38total
2022
2023
2024
2025
2026
Citations per year (5y)
30total
20222023202420252026

Selected Papers

15
1
Article|200 citations·1999
Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death
Jeong‐Hwa Lee, Takeshi Takahashi, Noriko Yasuhara, J. Inazawa, Shinji Kamada, Yoshihide Tsujimoto
SJR Q1Oncogene
Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
Article|51 citations·2008
HSP27 regulates cell adhesion and invasion via modulation of focal adhesion kinase and MMP-2 expression
Joong‐Won Lee, Joong-Won Lee, Hee‐Jin Kwak, Je‐Jung Lee, Je‐Jung Lee, Yong-Nyun Kim, Sang Eun Lee, Sang Eun Lee, Myung‐Jin Park, Seung Eun Jung, Seok‐Il Hong, Jeong‐Hwa Lee
SJR Q1European Journal of Cell Biology
Molecular BiologyBiochemistry, Genetics and Molecular Biology
3
Article|21 citations·2010
한국어 학습자를 위한 효과적인 토론 수업 방안-모국어 화자와 한국어 학습자 토론 담화 분석을 중심으로-
이정화

본고는 한국어 말하기 교육에서 토론 수업의 중요성을 밝히고 효과적인 토론 수업 방안을 모색하는 데 그 목적이 있다. 한국어 학습자의 학습 동기 별 토론 교육에 대한 학습자 요구를 조사한 결과 학습 동기에 따른 차이 없이 모든 학습자가 토론 교육에 대한 중요성을 고루 인식하고 있다는 것을 알 수 있었다. 또한 학문 목적으로 한국어를 배우고 한국의 대학에 재학 중인 한국어 학습자들을 대상으로 한 조사를 통해 학문 목적 학습자에게 토론 교육은 대학 학습 기술 개발을 위해서도 필수적임을 밝혔다. 본고의 최종적인 목표라 할 수 있는 효과적인 토론 수업 모형을 개발하기 위해 한국어 모어 화자와 한국어 학습자 토론 담화를 녹취, 비교 분석하였다. 두 집단의 토론 전략과 토론 표현 사용 양상을 검토한 결과 지금까지 한국어 학습자 토론 교육에서 강조되어 왔던 토론 표현의 지나친 사용이 오히려 토론의 자연스러운 전개를 저해하고 있는 것으로 관찰되었다. 두 집단의 토론 담화에서 보이는 가장 큰 차이는

4
Article|11 citations·2012
PCA-based high-dimensional noisy data clustering via control of decision errors
Jeong‐Hwa Lee, Chi‐Hyuck Jun
SJR Q1Knowledge-Based Systems
Artificial IntelligenceComputer Science
5
Article|6 citations·2023
Tumour necrosis factor stimulated gene 6 intrinsically regulates PD‐L1 expressions in breast cancer cells, leading to modulation of tumour microenvironment
Jeong‐Hwa Lee, Ju‐Hyun An, Hwa‐Young Youn
SJR Q1Veterinary and Comparative Oncology

Recent studies have shown that tumour cells express tumour necrosis factor-inducible gene 6 (TSG-6) and its protein, which is known to play a key role in regulating excessive immune responses and proliferation and growth of mesenchymal stem cells (MSCs). It has not been confirmed whether the inhibition of TSG-6 for tumour cells can suppress tumour cell growth and regulate the activation of immune cells in the tumour microenvironment (TME). TSG-6-specific small interfering RNA was transfected int

BiotechnologyBiochemistry, Genetics and Molecular Biology
6
Article|5 citations·2005
Improvement Strategies for Optimum Usage of Community Facilities by the Rural Elderly in Korea
Jeong‐Hwa Lee, Kyeong-Ha Kang, Nam-Su Jung, Gong-Ju Park, Soon-Duck Yoon
Journal of Korean Society of Rural Planning

Rural Korea has been becoming heavily aged societies from the end of 20th century due to the massive depopulation of young generation and extension of the average span of human beings. Although rural communities in Korea had been traditionally based on closely webbed social relations, almost all of community self-help organizations disappeared in recent time with very strong urbanization trend. However, almost all rural villages in Korea have the village seniors' union -'NO-IN-HOE' in Korean spe

Management, Monitoring, Policy and LawEnvironmental Science
7
Article|5 citations·2011
Deletion of thebisgene results in a marked increase in the production of corticosterone that is associated with thymic atrophy in mice
Dong‐Ye Youn, Jung‐Sook Yoon, Yong Kwan Kim, Chung Eun Yeum, Seong‐Beom Lee, Ho‐Joong Youn, Yoshihide Tsujimoto, Jeong‐Hwa Lee
SJR Q1American Journal of Physiology-Endocrinology and Metabolism

Bis (Bag3) is known to be involved in cell survival, migration, the regulating of chaperones, and protein quality control. We reported recently on the production of bis gene-deleted mice, which show early lethality within 3 wk after birth with a phenotype showing severe malnutrition and shrinkage of the thymus. In this report, we provide evidence to show that an intrinsic problem of adrenal gland is the the primary cause for the severe atrophy of the thymus in bis(-/-) mice. The bis(-/-) mice sh

Endocrinology, Diabetes and MetabolismMedicine
8
Article|4 citations·2008
Membranous glomerulonephritis associated with pancreatic tuberculosis
Jeong‐Hwa Lee, Jun-Ho Song, Ye-Ree Park, Jinyoung Kim, Chul-Woo Yang, Yong‐Soo Kim, Byung-Kee Bang
SJR Q2The Korean Journal of Internal MedicineOA

A 51-year old man presented with generalized edema for 10 days. He was admitted to the hospital for a renal biopsy, and a pancreatic mass was incidentally detected by ultrasonography. The renal biopsy was consistent with membranous glomerulonephritis and the pancreas biopsy revealed chronic granulomatous inflammation with multinucleated giant cells, which was suggestive of tuberculosis of the pancreas. The patient was initially treated with a steroid and anti-tuberculosis drugs, but the proteinu

SurgeryMedicine
9
Article|3 citations·2003
The Effects of the Social Support Network on the Psychological Well-Being of the Rural Elderly in Korea
Jeong‐Hwa Lee, Gyoung-Hae Han, Gong-Ju Park, Hanki Lee
Journal of Korean Society of Rural Planning

As the proportion of the elderly population in rural area is growing rapidly, the quality of life of the rural elderly is becoming a major concern. According to Rowe and Kahn(1997), active and productive engagement in society is a central component of successful aging. Yet, the effect of various social support network on psychological well-being of the rural elderly is not well known. This study is an attempt to empirically examine the connection between social support network and psychological

Management, Monitoring, Policy and LawEnvironmental Science
10
Article|3 citations·2025
ChatGPT-assisted writing: Learners’ perceptions of AI feedback and influencing factors
Jeong‐Hwa Lee
SJR Q2Korean Journal of English Language and Linguistics

This study explored the effects of using ChatGPT 3.5 (ChatGPT) on the attitudes and perceptions of English writing by 17 intermediate and 17 advanced university students. Paired t-test results for pre- and post-surveys found that both groups experienced a significant increase (intermediate: t=-3.392, p=.004; advanced: t=-3.050, p=.008) in confidence towards English. ChatGPT was found to be beneficial for creating ideas, strengthening vocabulary, and enhancing writing abilities by the two groups.

Health InformaticsMedicine
11
Article|3 citations·2021
Role of serum high-motility group box-1 (HMGB1) concentration as a prognostic factor in canine acute pancreatitis: A pilot study
Jeong‐Hwa Lee, Woo‐Jin Song, Ju‐Hyun An, Hyung‐Kyu Chae, Su-Min Park, Qiang Li, Hwa‐Young Youn
SJR Q1Research in Veterinary ScienceOA

High-mobility group box-1 (HMGB1) is an intranuclear molecule that is released extracellularly in cytotoxic conditions. In acute pancreatitis, extracellular HMGB1 acts as a stimulating factor in the mechanism associated with pancreatic injury. To evaluate the prognostic property of serum HMGB1 levels at the time of diagnosis of pancreatitis, the blood samples collected over 10 months from canine patients in Seoul National University Veterinary Medical Teaching Hospital (n = 29). The HMGB1 levels

GeneticsBiochemistry, Genetics and Molecular Biology
12
Article|2 citations·2010
쓰기 採點의 信賴度 確保 方案 -고급 한국어 학습자 主觀式 쓰기 문항 採點 實驗을 바탕으로-
이정화
어문연구(語文硏究)

본 硏究는 한국어 수업 교실에서 이루어지고 있는 쓰기 能力에 대한 成就度 評價를 대상으로 하여 評價 結果에 대한 信賴度를 確保하기 위한 방안을 모색하는 데 그 目的이 있다. 이를 위하여 먼저, 현재 韓國語 敎育機關들에서 사용하고 있는 쓰기 成就度 評價 항목들을 소개하고 보다 정밀한 評價 基準이 필요함을 지적하였다. 이어 쓰기 성취도 평가 주관식 문항에 대해 채점 基準을 달리 하는 경우와 採點者를 달리 하는 경우의 採點 結果를 비교하는 採點 實驗을 통하여 評價 基準과 採點 方式, 採點者에 따라 달라지는 評價 結果의 차이를 보이고 이를 統計的으로 해석함으로써, 採點者 訓練과 정밀한 評價 基準 樹立의 重要性을 보이고 있다. 쓰기 採點의 信賴度 確保를 위해서는 主觀式 문항의 客觀的 평가를 위한 機關 차원의 採點 基準 수립과 採點者 訓練이 필수적이다.

13
Article|2 citations·2007
Degos병이 합병된 전신홍반루푸스 1예
이정화, 류희정, 박영배, 최병용, 이은영, 이윤종, 이은봉, 송영욱

Degos' disease, malignant atrophic papulosis, is a rare disease characterized by a pathognomonic appearance of porcelain-white, atrophic papules with peripheral erythema and multiple occlusive thrombotic vascular pathology. It sometimes involves internal viscera such as the gastrointestinal tract, the central nervous system and kidney which may bring to death. Although several reports showed the associations between Degos' disease and antiphospholipid antibody or systemic lupus erythematosus, it

14
Article|2 citations·2020
블랙패션마니아의 추구이미지와 패션스타일
이정화, 하지수
한국의류산업학회지

This study classifies black fashion-mania by each type based on their motivation for wearing black fashion as well as verifies how they express their style. To achieve the objectives of this study, the research questions are as follows. First, the images of black fashion-manias are classified. Second, each type of black fashion enthusiasts’ motivations for wearing black fashion are verified. Last, black fashion-mania style are analyzed according to image types. In order to answer the research qu

15
Article|1 citations·2005
A case of antiphospholipid syndrome with Crohn's disease
Jeong‐Hwa Lee, Jong-Hyub Lee, Sang‐Hyun Kim, Jong‐Hyun Kim, Jung-Up Hwang, Chaekyu Kim, Seong-Ho Choi
SJR Q2The Korean Journal of Internal MedicineOA

Antiphospholipid syndrome has received considerable attention due to its association with a number of serious clinical disorders including arterial and venous throboembolism, acute ischemic encephalopathy, and recurrent pregnancy loss. Thrombotic episodes are we ll recognized complication of Crohn's disease. Hypercoagulable state of the disease may be responsibl e for such thrombotic events. The association of IBD and autoimmune condition is also well recogn ized, even poorly understood. There m

RheumatologyMedicine

Research Areas

Molecular BiologyPlant ScienceSurgeryCancer ResearchPharmacologyGenetics

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