Ji-won Shim
Seoul National University · Immunology and Microbiology
About the Lab
Professor Ji-won Shim's research lab focuses on the metabolic regulation of innate immunity, particularly in invertebrate models such as *Drosophila melanogaster*. The lab investigates how immune cells reprogram their metabolism during activation and development, integrating metabolic flux analysis with single-cell omics to uncover mechanisms underlying immune cell fate decisions. A central theme is understanding mitochondrial metabolism in hematopoietic-like cells, especially during immune responses such as lamellocyte differentiation. The lab also emphasizes the development and standardization of *Drosophila* research methodologies to ensure reproducible and reliable experimental outcomes.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
2Abstract Innate immune cells rapidly reprogram their metabolism upon activation, yet the metabolic basis of this flexibility in invertebrate systems remains largely unexplored. Here, we investigate the metabolic landscape of Drosophila larval hemocytes, functional analogs of vertebrate myeloid cells, across developmental stages, genotypes, and immune activation states, by combining metabolic flux measurements with single-cell transcriptomics. Under homeostatic conditions, hemocytes rely predomin
Drosophila melanogaster is a powerful genetic model organism due to its short life cycle, simple husbandry, and versatile genetic toolkit. Reliable experimental outcomes, however, depend on standardized husbandry and stock maintenance practices that are often underemphasized in research protocols. Here, we provide a concise, practical guide covering essential procedures for Drosophila culture conditions, anesthetization, phenotypic sorting, genetic crosses, developmental synchronization, and use
Research Areas
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