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Ji Yeoun Lee

Seoul National University · Medicine

About the Lab

Professor Ji Yeoun Lee's research lab focuses on developmental neuroscience and pediatric health, with a strong emphasis on early childhood language development, neurocognitive outcomes in pediatric cerebrovascular diseases such as moyamoya disease, and postoperative complications in pediatric and adult surgical populations. The lab investigates the interplay between family environment, parental behaviors, and child language acquisition, while also exploring the biological mechanisms underlying cerebrovascular disorders and their impact on cognitive function. A key direction involves identifying genetic and cellular factors—such as endothelial progenitor cell dysfunction—in the pathogenesis of moyamoya disease.

child language developmentneurocognitive outcomesmoyamoya diseasepediatric surgerygene expression profiling

Research Overview

Papers
331
Total Citations
6,740
Papers (5y)
63
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
63total
2022
2023
2024
2025
2026
Citations per year (5y)
190total
20222023202420252026

Selected Papers

15
1
Article|85 citations·2008
아동초기 사회경제적 지위(SES)와 가정환경이 언어발달에 미치는 영향
이지연, 곽금주

본 연구는 소득, 부모 학력 및 가정환경의 물리적 측면과 행동적 측면이 아동의 언어발달에 미치는 영향과 3세 때 가정환경의 영향이 4세에도 지속되는지를 알아보는 것이 목적이었다. 3세에는 266명이 참여하였으며, 이중에서 92명이 4세에도 참여하였다. 3세에는 가정환경(HOME)과 아동발달검사(K-CDI)의 언어 소검사를 실시하였으며, 4세에는 피바디 그림어휘검사(PPVT)를 사용하여 이해어휘를 측정하였다. 3세의 가정환경은 물리적 영역과 행동적 영역으로 나누어졌으며, 각 영역은 다시 두 개의 범주로 세분되었다. 그 결과, 첫째, 3세의 수입, 학력, 가정환경의 행동적 영역과 물리적 영역 모두 3세 언어발달과 정적 상관이 있었으며, 4세 어휘와는 유의한 상관이 없었다. 둘째, 어머니의 학력과 가정환경의 행동적 영역은 표현언어를 예측하였으며, 행동적 영역의 학습적 행동과 물리적 영역의 학습자극은 언어이해를 예측하였다. 소득계층별로 저소득층은 어머니의 학력과 물리적 학습자극이 그리고 중

2
Article|71 citations·2004
어머니의 책읽기 상호작용 유형이 영아의 초기 어휘발달에 미치는 영향
이지연, 이근영, 장유경

본 연구는 어머니의 언어적 상호작용 유형이 영아의 어휘발달에 어떤 영향을 미치는가를 알아보고자 하였다. 13~36개월(N=40) 영아를 대상으로 어머니가 글 없는 그림책을 읽어 주는 동안 나타나는 어머니의 언어적 행동을 5가지 언어적 상호작용 유형으로 범주화하고, 영아의 어휘능력은 발화수, 어휘수, 어휘 종류수를 측정하였다. 그 결과, 어머니의 언어적 상호작용 유형 중 피드백은 영아의 어휘 종류수를 유의하게 설명하였다. 또한 저연령에서는 피드백과 주의환기가 많을수록 어휘발달이 촉진되고, 고연령에서는 피드백이 많고 설명이 적을수록 어휘발달에 긍정적인 효과가 있는 것으로 나타났다. 본 연구의 결과는 피드백과 같이 영아의 반응에 대해 언어적인 반응을 보이는 어머니의 상호작용 유형이 영아의 언어발달에 중요하며, 연령에 따라 다른 상호작용 방법이 언어발달에 도움을 준다는 것을 시사한다.

3
Article|66 citations·2010
Neurocognitive Profiles of Children with Moyamoya Disease before and after Surgical Intervention
Ji Yeoun Lee, Ji Hoon Phi, Kyu‐Chang Wang, Byung-Kyu Cho, Min‐Sup Shin, Seung‐Ki Kim
SJR Q2Cerebrovascular Diseases

BACKGROUND: Clinical research on moyamoya disease (MMD) has focused on symptomatic outcome such as transient ischemic attacks. Neurocognitive function in children critically affects social outcome and is closely related to quality of life. This study is the first to analyze the neurocognitive profiles of children with MMD before and after surgery. METHODS: Sixty-five patients were selected out of 137 who underwent surgery for MMD between 2006 and 2008. The preoperative and postoperative neurocog

RheumatologyMedicine
4
Article|58 citations·2012
Enlarging arachnoid cyst: a false alarm for infants
Ji Yeoun Lee, Jin Wook Kim, Ji Hoon Phi, Seung‐Ki Kim, Byung-Kyu Cho, Kyu‐Chang Wang
SJR Q2Child s Nervous System
Cellular and Molecular NeuroscienceNeuroscience
5
Article|55 citations·2010
Is MRI a reliable tool to locate the electrode after deep brain stimulation surgery? Comparison study of CT and MRI for the localization of electrodes after DBS
Ji Yeoun Lee, Jin Wook Kim, Jee‐Young Lee, Yong Hoon Lim, Cheolyoung Kim, Dong Gyu Kim, Beom Seok Jeon, Sun Ha Paek
SJR Q1Acta Neurochirurgica
NeurologyMedicine
6
Article|40 citations·2014
Delayed posterior circulation insufficiency in pediatric moyamoya disease
Ji Yeoun Lee, Young Hun Choi, Jung‐Eun Cheon, Jin Chul Paeng, Hye Won Ryu, Ki Joong Kim, Ji Hoon Phi, Kyu‐Chang Wang, Byung-Kyu Cho, Jong‐Hee Chae, Seung‐Ki Kim
SJR Q1Journal of Neurology
RheumatologyMedicine
7
Article|39 citations·2013
Posterior cerebral artery involvement in moyamoya disease: initial infarction and angle between PCA and basilar artery
Ji Yeoun Lee, Seung-Ki Kim, Jung‐Eun Cheon, Jung Won Choi, Ji Hoon Phi, In-One Kim, Byung Kyu Cho, Kyu‐Chang Wang
SJR Q2Child s Nervous SystemOA
RheumatologyMedicine
8
Article|37 citations·2011
Risk Factors of Postoperative Pneumonia after Lung Cancer Surgery
이지연, 진상만, 이창훈, 이병준, 강창현, 임재준, 김영태, 양석철, 유철규, 한성구, 김주현, 심영수
Journal of Korean Medical Science

The purpose of this study was to investigate risk factors of postoperative pneumonia (POP)after lung cancer surgery. The 417 lung cancer patients who underwent surgical resection in a tertiary referral hospital were included. Clinical, radiological and laboratory data were reviewed retrospectively. Male and female ratio was 267:150 (median age, 65 yr). The incidence of POP was 6.2% (26 of 417) and in-hospital mortality was 27% among those patients. By univariate analysis, age ≥ 70 yr (P < 0.001)

9
Article|35 citations·2008
Intracranial Pial Arteriovenous Fistulas
Ji Yeoun Lee, Young‐Je Son, Jeong Eun Kim
SJR Q2Journal of Korean Neurosurgical SocietyOA

Intracranial pial arteriovenous fistula (AVF) is a rare cerebrovascular lesion that has only recently been recognized as a distinct pathological entity. A 41-year-old woman (Patient 1) presented with the sudden development of an altered mental state. Brain CT showed an acute subdural hematoma. A red sylvian vein was found intraoperatively. A pial AVF was revealed on postoperative angiography, and surgical disconnection of the AVF was performed. A 10-year-old boy (Patient 2) presented with a 10-d

NeurologyMedicine
10
Article|34 citations·2015
Deregulation of Retinaldehyde Dehydrogenase 2 Leads to Defective Angiogenic Function of Endothelial Colony–Forming Cells in Pediatric Moyamoya Disease
Ji Yeoun Lee, Youn Joo Moon, Hae‐Ock Lee, Ae-Kyung Park, Seung-Ah Choi, Kyu‐Chang Wang, Jung Woo Han, Je‐Gun Joung, Hyun Seung Kang, Jeong Eun Kim, Ji Hoon Phi, Woong‐Yang Park
SJR Q1Arteriosclerosis Thrombosis and Vascular Biology

OBJECTIVE--: Moyamoya disease (MMD) is a common cause of childhood stroke, in which the abnormal function of the endothelial colony-forming cell (ECFC) plays a key role in the pathogenesis of the disease. This study was designed to identify genes involved in MMD pathogenesis using gene expression profiling and to understand the defective function of MMD ECFCs. APPROACH AND RESULTS--: We compared gene expression profiles of ECFCs isolated from patients with MMD and normal controls. Among the diff

RheumatologyMedicine
11
Article|33 citations·2014
miRNA expression analysis in cortical dysplasia: Regulation of mTOR and LIS1 pathway
Ji Yeoun Lee, Ae-Kyung Park, Eun-Sun Lee, Woong‐Yang Park, Sung‐Hye Park, Jung Won Choi, Ji Hoon Phi, Kyu‐Chang Wang, Seung‐Ki Kim
SJR Q2Epilepsy Research
Cancer ResearchBiochemistry, Genetics and Molecular Biology
12
Article|32 citations·2017
Modification of surgical procedure for “probable” limited dorsal myeloschisis
Ji Yeoun Lee, Sangjoon Chong, Young Hun Choi, Ji Hoon Phi, Jung‐Eun Cheon, Seung-Ki Kim, Sung‐Hye Park, In-One Kim, Kyu‐Chang Wang
SJR Q1Journal of Neurosurgery PediatricsOA

OBJECTIVE Since the entity limited dorsal myeloschisis (LDM) was proposed, numerous confusing clinical cases have been renamed according to the embryopathogenesis. However, clinical application of this label appears to require some clarification with regard to pathology. There have been cases in which all criteria for the diagnosis of LDM were met except for the presence of a neural component in the stalk, an entity the authors call "probable" LDM. The present study was performed to meticulously

Public Health, Environmental and Occupational HealthMedicine
13
Article|32 citations·2016
다문화청소년의 차별경험이 생활만족도에 미치는 영향과 대처전략의 조절효과
이지연, 그레이스정

이 연구는 다문화가족에 대한 차별이 존재하는 한국사회에서 다문화청소년이 경험하는 차별이 생활만족도에 미치는 영향을 확인하고, 차별의 부정적인 영향을 스트레스 대처전략의 각 유형이 어떻게 조절하는가를 살펴보기 위해 수행되었다. 이를 위해 다문화청소년과 어머니 227쌍을 대상으로 수집한 자료를 활용하여 만10-15세 초기청소년 211명을 분석하였다. 다문화청소년의 생활만족도를 종속변수로, 이들이 경험한 차별의 강도를 독립변수로, 스트레스 대처전략의 각 유형을 점수화하여 조절변수로 하는 회귀분석을 실시한 결과는 다음과 같다. 첫째, 다문화청소년이 경험하는 차별의 강도는 생활만족도에 부정적인 영향을 미쳤다. 둘째, 적극적 문제해결은 다문화청소년의 생활만족도와 정적인 상관이 있었으나, 심한 차별의 상황에서는 적극적 문제해결이 오히려 생활만족도를 더 낮추었다. 셋째, 소극적 문제해결은 차별의 부정적인 영향을 더욱 증폭시켰다. 넷째, 차별이 심한 상황에서는 회피가 오히려 더 적응적인 결과를 가져

14
Article|31 citations·2017
Stimulation of osteoclast migration and bone resorption by C–C chemokine ligands 19 and 21
이지연, 박철규, 김형준, 이용덕, 이장희, 송영욱, 김홍희

Osteoclasts are responsible for the bone erosion associated with rheumatoid arthritis (RA). The upregulation of the chemokines CCL19 and CCL21 and their receptor CCR7 has been linked to RA pathogenesis. The purpose of this study was to evaluate the effects of CCL19 and CCL21 on osteoclasts and to reveal their underlying mechanisms. The expression of CCL19, CCL21 and CCR7 was higher in RA patients than in osteoarthritis patients. In differentiating osteoclasts, tumor necrosis factor-α, interleuki

15
Article|30 citations·2011
MGMT promoter gene methylation in pediatric glioblastoma: analysis using MS-MLPA
Ji Yeoun Lee, Chul‐Kee Park, Sung‐Hye Park, Kyu‐Chang Wang, Byung Kyu Cho, Seung‐Ki Kim
SJR Q2Child s Nervous System
GeneticsMedicine

Research Areas

GeneticsRheumatologyPublic Health, Environmental and Occupational HealthMolecular BiologySurgeryCellular and Molecular Neuroscience

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