Jin-ju Cha

The concentration of adenosine in the normal kidney increases markedly during renal hypoxia, ischemia, and inflammation. A recent study reported that an A3 adenosine receptor (A3AR) antagonist attenuated the progression of renal fibrosis. The adriamycin (ADX)-induced nephropathy model induces podocyte injury, which results in severe proteinuria and progressive glomerulosclerosis. In this study, we investigated the preventive effect of a highly selective A3AR antagonist (LJ1888) in ADX-induced ne

The spexin-based GALR2 agonist (NS200) is a novel drug, which has shown antidepressant andanxiolytic action in a recent experimental study. In this study, we investigated the effects ofNS200 on renal injury in an animal model of type 2 diabetes. Eight-week-old diabetic db/dbmice were administered NS200 for 12 weeks. NS200 was intraperitoneally administered at adose of 1.0 mg/kg/day. Metabolic parameters and structural and molecular changes in thekidneys were compared among the three groups: non-

Background: Obesity-related metabolic disorders are closely associated with inflammation induced by innate immunity. Toll-like receptors (TLRs) play a pivotal role in the innate immune system by activating proinflammatory signaling pathways. GIT27 (4,5-dihydro-3-phenyl-5-isoxasole acetic acid) is an active immunomodulatory agent that primarily targets macrophages and inhibits secretion of tumor necrosis factor α [as well as interleukin (IL)-1β, IL-10, and interferon γ]. However, the effect of TL

Puromycin treatment can cause glomerular injury to the kidney, leading to proteinuria. However,the pathogenesis of acute kidney injury and subsequent regeneration after puromycinadministration in animal models remain unclear. In this work, we examined the characteristicsof kidney injury and subsequent regeneration following puromycin treatment in adult zebrafish. We intraperitoneally injected 100 μg of puromycin into zebrafish; sacrificed them at 1, 3, 5, 7, or14 days post-injection (dpi); and e

목 적 : 우울증 환자에서 염증 반응의 증가가 관찰되며, 심혈관계 합병증이 증가한다는 것이 알려져 있다. 또한 만성신부전 환자의 주된 사망 원인은 심혈관계 합병증이며, 우울 증상은 만성신부전 환자에서 흔히 관찰되는 증상이다. 이 연구의 목적은 유지 혈액투석을 받고 있는 만성신부전 환자에서 우울 증상과 다양한 염증 표지자 및 심혈관계 합병증의 위험 요소들과의 연관 관계를 밝히는 것이다. 방 법 : 고려대학교 안암 병원에서 유지 혈액투석을 받고 있는 53명의 환자들을 대상으로 연구하였다. Beck 우울증 척도(BDI)가 11 이상인 환자들을 우울 증상군으로, 10 이하인 환자들을 대조군으로 정의하였다. 의무기록을 통해 각 군의 환자들의 특성과 검사소견을 수집하였으며, 각 환자군에서 혈중 IL-10, TNF-ㄷ 농도를 측정하고, IL-10 과 TNF-α 프로모터 영역의 유전형 변이를 분석하였다. 결 과 : TNF-α , CRP 및 ferritin의 농도는 우울 증상군에서 유의하게 높았으

Purpose: Cardiovascular diseases are a common cause of mortality in patients with end stage renal disease and are associated with vascular calcification (VC) and arterial stiffness. In addition to high turnover bone disease, there is substantial evidence that low levels of serum intact PTH (iPTH) are associated with vascular calcium deposition. The objective was to evaluate the association of iPTH levels with VC, arterial stiffness, and to identify risk factors contributing to VCs and arterial s

A renal infarct is too rare a disease for early diagnosis and treatment. Furthermore, it presents nonspecific symptoms in many patients. Cardiac diseases such as valvular heart disease and arterial fibrillation are the most common causes of renal infarct. Vascular disease such as renal artery dissection or aortic dissection, trauma, inflammation, vasculitis, malignancy and antiphospholipid syndrome have been also known as possible causes of renal infarct. In acute pancreatitis, adjacent vessels

Background Aging is a risk factor for development of chronic kidney disease and diabetes mellitus with commonly shared features of chronic inflammation and increased oxidative stress. Here, we investigated the effect of pan-Nox-inhibitor, APX-115, on renal function in aging diabetic mice. Methods Diabetes was induced by intraperitoneal injection of streptozotocin at 50 mg/kg/day for 5 days in 52-week-old C57BL/6J mice. APX-115 was administered by oral gavage at a dose of 60 mg/kg/day for 12 week

A 27-year-old woman presented with severe hypertension and nephrotic range proteinuria. She had a blunt renal trauma 4 weeks ago and was treated by the left main renal artery ligation. The plasma renin activity, angiotension II and aldosterone levels were very high and the abdominal angiography showed the occlusion of the left main renal artery with relatively preserved blood flow in upper pole of the left kidney. In captopril renal scan, relatively preserved perfusion in upper pole of left kidn

The introduction of plasma exchange has significantly improved the outcome of thrombotic thrombocytopenic purpura (TTP) and the survival rate was increased from 10 to 80-90%. TTP refractory to plasma exchange therapy, however, is still a therapeutic challenge. We describe here a patient who partially responded to plasma exchange therapy, but remained dependent on plasma infusions. To discontinue plasma therapy, several attempts using agents such as rituximab, vincristine, and cyclosporine A had

Pseudomyxoma peritonei is a rare clinical condition that causes the accumulation of mucinous ascites, which gradually results in the compression of intra-abdominal organs. Most published reports of pseudomyxoma peritonei concern the mass effect of the resulting ascites, which presents as abdominal pain or intestinal ileus in severe cases. However, few reports of renal complications of the disease have been published. Here, we present a case of oliguric acute kidney injury caused by external comp

면역글로불린 G4 연관성 질환(IgG4-related disease, IgG4-RD) 은 최근 보고된 새로운 질병군으로 다발 장기를 침범하는특징을 가진 섬유염증성 질환이다[1,2]. 이 질환군은 다수의면역글로불린 G4 양성세포가 조직내 침투해 있는 병리 소견을 보이며, 여러 보고들에 의해 췌장, 담도, 침샘, 뇌수막, 림프선, 폐, 신장 등을 침범하는 것이 알려져 있다[3,4]. IgG4-RD의치료는 아직까지 확립된 바가 없으며, 치료에 대한 무작위가부족한 상태로 현재의 치료는 증례보고 및 전문가 의견에의존하고 있다[1]. 저자는 재발성 IgG4-RD 환자에서 마이코페놀릭산(mycophenolic acid, MPA) 투약을 통해 성공적으로질병의 활성이 조절되어 장기간 유지된 증례를 경험하여 보고하고자 한다.