Jin-Kyu Lee

Biomaterials with suitable surface modification strategies are contributing significantly to the rapid development of the field of bone tissue engineering. Despite these encouraging results, utilization of biomaterials is poorly translated to human clinical trials potentially due to lack of knowledge about the interaction between biomaterials and the body defense mechanism, the "immune system". The highly complex immune system involves the coordinated action of many immune cells that can produce

Organic dye-incorporated smart silica-coated core–shell magnetic nanoparticles (MNP@SiO2) having dual-functionality (-PEG/NH2, see Figure) were easily fabricated, and the amine moieties on the NP surface were modified with maleimide functionality for specific covalent immobilization of biopolymers and bioactive small molecules. The sequence-independent immobilization of antibodies (Ab) is highlighted; Ab-modified MNP@SiO2 particles exhibit specific recognition for floating tumor cells or target

Aminofunctional trialkoxysilanes such as aminopropyltrimethoxysilane (APTMS) and (3‐trimethoxysilylpropyl)diethylenetriamine (DETAS) were employed as a surface modification molecule for generating monolayer modification on the surface of silica (SiO 2 ) nanoparticles. We were able to quantitatively analyze the number of amine functional groups on the modified SiO 2 nanoparticles by acid‐base back titration method and determine the effective number of amine functional groups for the successive ch

A new synthetic method has been developed to prepare fluorescent silica nanoparticles without employing isothiocyanated dye molecules and (3-aminopropyl)triethoxysilane (APS) for the thiourea linkage formation; the resulting fluorescent silica nanoparticles show excellent photochemical, thermal and pH stabilities and a good biocompatibility with over 85% viability from various cell types.

Zellen in Bewegung: Multifunktionelle, biokompatible Nanopartikel mit einer einzigartigen Kombination von magnetischen und Fluoreszenzeigenschaften wurden hergestellt. Anschließend wurde ihre Aufnahme durch Zellen untersucht und ein externer „Magnetmotoreffekt“ auf die Nanopartikel-haltigen Zellen nachgewiesen (siehe Schema). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for

The use of engineered scaffolds or stem cells is investigated widely in the repair of injured musculoskeletal tissue. However, the combined regeneration of hierarchical osteochondral tissue remains a challenge due to delamination between cartilage and subchondral bone or difficulty in spatial control over differentiation of transplanted stem cells. Here, two types of composite spheroids are prepared using adipose-derived stem cells (hADSCs) and nanofibers coated with either transforming growth f

We have developed a simple, efficient, and highly reproducible method to fabricate the large-area biomimetic superhydrophobic polymer surfaces having hierarchical structures of micrometer-sized irregular steps and nanometer-sized fibrils. Commercial Al plates (99.0%) were etched using Beck's dislocation etchant (mixture of HCl and HF) for different time periods in order to alter the structure of the etched Al surfaces from micrometer-sized to highly rough nanometer-sized irregular steps. These h

Singlet oxygen is a toxic chemical but powerful oxidant, exploited in many chemical and biological applications. However, the lifetime of singlet oxygen in air under atmospheric conditions is yet to be known. This has limited safe usage of singlet oxygen in air, despite being a strong antimicrobial agent with the unique property of relaxing to breathable oxygen after serving its purpose. Here, we solve this long-standing problem by combining experimental and theoretical research efforts; we gene

New generation dual-mode imaging probes for MRI and Raman imaging techniques are developed, inspired by the hyper intense contrast enhancing capability in T1 -weighted MRI and characteristic Raman signal of natural melanin. MDA-MB-231cells labeled with dual-mode imaging probe are successfully detected in both T1-weighted MRI and Raman imaging.

We have successfully fabricated triacetylcellulose (TAC) polymer-silica nanocomposite films having up to 40 wt % of incorporated silica nanoparticles by deliberately designing a surface ligand that has a structure similar to that of polymer repeating units and effectively modifying the surface of silica nanoparticles through chemical bonding. Cross-sectional TEM analysis reveals no significant aggregation in all TAC-silica nanocomposite films. Thermal analysis results suggested that TAC-silica n

A novel metal–semiconductor and/or heterodimensional nanohybrid material (CdS–MoS2) is synthesized by hybridizing catalytically important materials (i.e., zero-dimensional CdS quantum dots and two-dimensional, unilamellar MoS2 sheets). According to our high-resolution transmission electron microscopic (HRTEM) analyses on the present nanohybrid, ca. 6.5 nm CdS quantum dots are successfully immobilized in the interlayer space of MoS2 sheets. The microscopic internal structure of the CdS–MoS2 nanoh