John Ames
Sungkyunkwan University · Biochemistry, Genetics and Molecular Biology
About the Lab
Professor John Ames's research lab specializes in integrating long-term ecological field studies with advanced genomics to investigate the evolutionary processes shaping natural populations. The lab focuses on understanding how dispersal, gene flow, genetic drift, and natural selection interact to shape genetic structure and allele frequency dynamics in wild populations, using the Florida Scrub-Jay as a model system. By combining detailed pedigree data with high-throughput genomic analyses, the lab develops and applies novel statistical and bioinformatic methods to address fundamental questions in population genetics and evolutionary biology. Additionally, the lab contributes to materials science by studying nanoscale microstructures and thermoelectric properties in complex chalcogenide materials.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Geographically limited dispersal can shape genetic population structure and result in a correlation between genetic and geographic distance, commonly called isolation-by-distance. Despite the prevalence of isolation-by-distance in nature, to date few studies have empirically demonstrated the processes that generate this pattern, largely because few populations have direct measures of individual dispersal and pedigree information. Intensive, long-term demographic studies and exhaustive genomic su
A central goal of population genetics is to understand how genetic drift, natural selection, and gene flow shape allele frequencies through time. However, the actual processes underlying these changes—variation in individual survival, reproductive success, and movement—are often difficult to quantify. Fully understanding these processes requires the population pedigree, the set of relationships among all individuals in the population through time. Here, we use extensive pedigree and genomic info
Exceptionally high thermoelectric figure of merit (zT>2), has been reported for (Ag1−ySbTe2)0.05(PbTe)0.95, which may involve the nanoscale microstructure. However, conflicting reports on the same materials claim only zT of 1 or less. Here we show that (Ag1−ySbTe2)0.05(PbTe)0.95 materials are multiphase on the scale of millimeters despite appearing homogeneous by x-ray diffraction and routine electron microscopy. Using a scanning Seebeck microprobe, we find significant variation of Seebec
Abstract Background The female-specific W chromosomes and male-specific Y chromosomes have proven difficult to assemble with whole-genome shotgun methods, creating a demand for new approaches to identify sequence contigs specific to these sex chromosomes. Here, we develop and apply a novel method for identifying sequences that are W-specific. Results Using the Illumina Genome Analyzer, we generated sequence reads from a male domestic chicken (ZZ) and mapped them to the existing female (ZW) genom
Restriction site-associated DNA sequencing or genotyping-by-sequencing (GBS) approaches allow for rapid and cost-effective discovery and genotyping of thousands of single-nucleotide polymorphisms (SNPs) in multiple individuals. However, rigorous quality control practices are needed to avoid high levels of error and bias with these reduced representation methods. We developed a formal statistical framework for filtering spurious loci, using Mendelian inheritance patterns in nuclear families, that
ABSTRACT A central goal of population genetics is to understand how genetic drift, natural selection, and gene flow shape allele frequencies through time. However, the actual processes underlying these changes - variation in individual survival, reproductive success, and movement - are often difficult to quantify. Fully understanding these processes requires the population pedigree, the set of relationships among all individuals in the population through time. Here, we use extensive pedigree and
AbstractSystems of oppression-racism, colonialism, misogyny, cissexism, ableism, heteronormativity, and more-have long shaped the content and practice of science. But opportunities to reckon with these influences are rarely found within academic science, even though such critiques are well developed in the social sciences and humanities. In this special section, we attempt to bring cross-disciplinary conversations among ecology, evolution, behavior, and genetics on the one hand and critical pers
Abstract Geographically limited dispersal can shape genetic population structure and result in a correlation between genetic and geographic distance, commonly called isolation-bydistance. Despite the prevalence of isolation-by-distance in nature, to date few studies have empirically demonstrated the processes that generate this pattern, largely because few populations have direct measures of individual dispersal and pedigree information. Intensive, long-term demographic studies and exhaustive ge
Isolation caused by anthropogenic habitat fragmentation can destabilize populations. Populations relying on the inflow of immigrants can face reduced fitness due to inbreeding depression as fewer new individuals arrive. Empirical studies of the demographic consequences of isolation are critical to understand how populations persist through changing conditions. We used a 34-year demographic and environmental dataset from a population of cooperatively breeding Florida Scrub-Jays (Aphelocoma coerul
Sex differences in plumage color in hybrid canaries are controlled by a single enzyme
Sex-biased demography, including sex-biased survival or migration, can alter allele frequency changes across the genome. In particular, we can expect different patterns of genetic variation on autosomes and sex chromosomes due to sex-specific differences in life histories, as well as differences in effective population size, transmission modes, and the strength and mode of selection. Here, we demonstrate the role that sex differences in life history played in shaping short-term evolutionary dyna
Abstract Cooperatively breeding species frequently live in family groups of related individuals, with helpers delaying their own reproduction and participating in alloparental care, predator vigilance, and territory defense. It remains challenging to disentangle the roles of the indirect fitness benefits of helping kin and the potential direct fitness benefits helpers receive in the evolution of cooperative breeding. While many studies test for associations between helper relatedness and helping
Abstract Background Few studies have investigated the relationship between subjective cognitive concerns and objective cognitive decline in the oldest‐old or examined gender differences. We evaluated this association and stratification by gender in a diverse cohort of adults ages 90+. Methods LifeAfter90 is an ongoing cohort of adults ages 90+. Verbal episodic memory (VEM) and executive function (EF) were assessed every 6‐months since 2018 using the Spanish and English Neuropsychological Assessm
Research Areas
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