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Joon Seong Park

Seoul National University · Medicine

About the Lab

Professor Joon Seong Park's research lab specializes in clinical and translational oncology, with a focus on gastrointestinal and hepatobiliary cancers. The lab investigates treatment strategies, prognostic factors, and molecular mechanisms underlying diseases such as hepatocellular carcinoma, pancreatic cancer, and ampulla of Vater carcinoma. Key research directions include the impact of therapeutic modalities on metastatic disease, the role of biomarkers like LOXL2 in cancer progression, and surgical outcomes with innovative techniques such as TachoSil patch use in pancreatectomy. The lab also explores nutritional support strategies in postoperative recovery, particularly early enteral feeding after pancreatic surgery.

pancreatic canceradrenal metastasisLOXL2surgical oncologypostoperative nutrition

Research Overview

Papers
304
Total Citations
5,467
Papers (5y)
77
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
77total
2022
2023
2024
2025
2026
Citations per year (5y)
429total
20222023202420252026

Selected Papers

15
1
Article|227 citations·2001
Role-based access control on the web
Joon Seong Park, Ravi Sandhu, Gail‐Joon Ahn
ACM Transactions on Information and System Security

Current approaches to access control on the Web servers do not scale to enterprise-wide systems because they are mostly based on individual user identities. Hence we were motivated by the need to manage and enforce the strong and efficient RBAC access control technology in large-scale Web environments. To satisfy this requirement, we identify two different architectures for RBAC on the Web, called user-pull and server-pull . To demonstrate feasibility, we implement each architecture by integrati

Sociology and Political ScienceSocial Sciences
2
Article|141 citations·2009
Clinical validation and risk factors for delayed gastric emptying based on the International Study Group of Pancreatic Surgery (ISGPS) Classification
Joon Seong Park, Ho Kyoung Hwang, Jae Keun Kim, Sin Il Cho, Dong Sup Yoon, Woo Jung Lee, Sang Hoon
SJR Q1SurgeryOA
OncologyMedicine
3
Article|69 citations·2007
What is the best treatment modality for adrenal metastasis from hepatocellular carcinoma?
Joon Seong Park, Dong Sup Yoon, Kyung Sik Kim, Jin Sub Choi, Woo Jung Lee, Hoon Sang Chi, Byong Ro Kim
SJR Q1Journal of Surgical OncologyOA

PURPOSE: This study aimed to analyze the effect of each therapeutic modality to clarify the treatment strategy for adrenal metastases from hepatocellular carcinoma (HCC). METHODS: Adrenal metastasis from HCC was observed in 45 patients. Fifteen patients who were determined to have multi-organ metastasis including the adrenal glands were excluded, and the remaining 30 patients were reviewed. RESULTS: The location of adrenal metastasis was right side, left side, and both in 17, 9, and 4 patients,

SurgeryMedicine
4
Article|68 citations·2015
Use of TachoSil® patches to prevent pancreatic leaks after distal pancreatectomy: a prospective, multicenter, randomized controlled study
Joon Seong Park, Doo‐Ho Lee, Jin‐Young Jang, Youngmin Han, Dong Sup Yoon, Jae Keun Kim, Ho‐Seong Han, Yoo‐Seok Yoon, Dae Wook Hwang, Chang Moo Kang, Ho Kyoung Hwang, Woo Jung Lee
SJR Q1Journal of Hepato-Biliary-Pancreatic SciencesOA

BACKGROUND: We performed a prospective, multicenter, randomized controlled study to investigate the clinical outcomes, including postoperative pancreatic fistulas (POPF), after using the TachoSil® patch in distal pancreatectomy (NCT01550406). METHODS: Between June 2012 and September 2014, 101 patients at five centers were randomized into Control (n = 53) and TachoSil (n = 48) groups. In all patients, the pancreas was resected using a stapler with Endo-GIA™ staples. The TachoSil patch was wrapped

OncologyMedicine
5
Article|68 citations·2012
Postoperative Nutritional Effects of Early Enteral Feeding Compared with Total Parental Nutrition in Pancreaticoduodectomy Patients: A Prosepective, Randomized Study
Joon Seong Park, Hye-Kyung Chung, Ho Kyoung Hwang, Jae Keun Kim, Dong Sup Yoon
SJR Q2Journal of Korean Medical ScienceOA

The benefits of early enteral feeding (EEN) have been demonstrated in gastrointestinal surgery. But, the impact of EEN has not been elucidated yet. We assessed the postoperative nutritional status of patients who had undergone pancreaticoduodenectomy (PD) according to the postoperative nutritional method and compared the clinical outcomes of two methods. A prospective randomized trial was undertaken following PD. Patients were randomly divided into two groups; the EEN group received the postoper

OncologyMedicine
6
Article|67 citations·2007
Factors influencing recurrence after curative resection for ampulla of vater carcinoma
Joon Seong Park, Dong Sup Yoon, Kyung Sik Kim, Jin Sub Choi, Woo Jung Lee, Hoon Sang Chi, Byong Ro Kim
SJR Q1Journal of Surgical OncologyOA

BACKGROUND: Carcinoma of the ampulla of Vater has a relatively higher resection rate, lower recurrence rate, and more favorable prognosis than other malignant tumors of the periampullary region. Because of the relative low incidence of carcinoma of the ampulla of Vater, there have been few reports on the patterns and risk factors of recurrence after curative resection. The aim of this study was to evaluate the patterns and risk factors of recurrence after curative resection of ampulla of Vater c

OncologyMedicine
7
Article|57 citations·2016
Emerging role of LOXL2 in the promotion of pancreas cancer metastasis
Joon Seong Park, Ji-hae Lee, Yun Sun Lee, Jae Keun Kim, Seung Myung Dong, Dong Sup Yoon
SJR Q2OncotargetOA

Lysyl oxidase-like 2 (LOXL2) is associated with invasiveness and metastasis in cancer. We analyzed the prognostic impact of LOXL2 in pancreatic cancer patients and investigated the role of LOXL2 in pancreatic cancer cell lines. Immunohistochemical analysis was performed in samples from 80 patients and showed LOXL2 expression in 81.2% of patients with pancreatic cancer. Regarding recurrence patterns, LOXL2-positive tumors showed a significantly higher rate of distant recurrence. The 1-year and 3-

Molecular BiologyBiochemistry, Genetics and Molecular Biology
8
Article|56 citations·2019
Preoperative CT texture features predict prognosis after curative resection in pancreatic cancer
Hyung Sun Kim, Young Jae Kim, Kwang Gi Kim, Joon Seong Park
SJR Q1Scientific ReportsOA

Pancreatic cancer is a lethal disease, and resistance to chemotherapy is a critical factor influencing the postoperative prognosis. Tumour heterogeneity is an important indicator of chemoresistance. Therefore, we analysed tumour heterogeneity in preoperative computed tomography scans by performing texture analysis using the grey-level run-length matrix and analysed the correlation of survival with the value obtained in these analyses. We analysed 116 consecutive patients who underwent curative r

OncologyMedicine
9
Article|52 citations·2006
Dual Inverter Strategy for High Speed Operation of HEV Permanent Magnet Synchronous Motor
Joon Seong Park, Kwanghee Nam
Conference record

Bi-directional buck-boost DC/DC converter is normally utilized for high speed operation of motors for hybrid electric vehicles (HEV). In this work, a dual inverter strategy is proposed for HEV motor with the purpose of accommodating high speed operation without increasing battery voltage. By setting the secondary inverter to take care of only reactive voltage component, the secondary inverter do not carry voltage source other than capacitor bank. DC link voltage regulation is achieved through th

Electrical and Electronic EngineeringEngineering
10
Article|45 citations·2020
Cancer-initiating cells in human pancreatic cancer organoids are maintained by interactions with endothelial cells
Jae-Il Choi, Sung Ill Jang, Jaehyun Hong, Chul Hoon Kim, Soon Sung Kwon, Joon Seong Park, Jong‐Baeck Lim
SJR Q1Cancer LettersOA

Pancreatic ductal adenocarcinoma (PDAC) shows poor prognosis and high malignancy due to the presence of cancer-initiating cells (CICs) and characteristics of the tumor microenvironment (TME). Organoids are useful for studying PDAC, and establishing organoids is dependent on stem cell growth factors, including Wnt signaling. Herein, using a conventional organoid culture system, we demonstrated that CD44(+)CD24(+) and CD44(+)CD24(+)EpCAM(+) CICs were enriched >65% in a PDAC patient-derived organoi

OncologyMedicine
11
Article|42 citations·2019
Big data and analysis of risk factors for gallbladder disease in the young generation of Korea
Hyung Sun Kim, Seong Kyung Cho, Changsoo Kim, Joon Seong Park
SJR Q1PLoS ONEOA

In this study, obesity-related factors (BMI, waist size, thigh circumference, and cholesterol, LDL, and HDL levels) correlated with GB disease in the young generation of Korea.

Pulmonary and Respiratory MedicineMedicine
12
Article|40 citations·2014
The role of abdominal drainage to prevent of intra-abdominal complications after laparoscopic cholecystectomy for acute cholecystitis: prospective randomized trial
Joon Seong Park, Joo Hee Kim, Jae Keun Kim, Dong Sup Yoon
SJR Q1Surgical EndoscopyOA
Pulmonary and Respiratory MedicineMedicine
13
Article|38 citations·2023
SLC38A5 Modulates Ferroptosis to Overcome Gemcitabine Resistance in Pancreatic Cancer
Myeong‐Jin Kim, Hyung Sun Kim, Hyung Sun Kim, Hyeon Woong Kang, Da Eun Lee, Woosol Chris Hong, Ju-Hyun Kim, Min‐Soo Kim, Jae‐Ho Cheong, Hyo Jung Kim, Hyo Jung Kim, Joon Seong Park
SJR Q1CellsOA

Pancreatic cancer is characterized by a poor prognosis, with its five-year survival rate lower than that of any other cancer type. Gemcitabine, a standard treatment for pancreatic cancer, often has poor outcomes for patients as a result of chemoresistance. Therefore, novel therapeutic targets must be identified to overcome gemcitabine resistance. Here, we found that SLC38A5, a glutamine transporter, is more highly overexpressed in gemcitabine-resistant patients than in gemcitabine-sensitive pati

Pulmonary and Respiratory MedicineMedicine
14
Article|37 citations·2007
Actual Recurrence Patterns and Risk Factors Influencing Recurrence After Curative Resection with Stage II Gallbladder Carcinoma
Joon Seong Park, Dong Sup Yoon, Kyung Sik Kim, Jin Sub Choi, Woo Jung Lee, Hoon Sang Chi, Byong Ro Kim
SJR Q1Journal of Gastrointestinal SurgeryOA
SurgeryMedicine
15
Article|34 citations·2012
Current Status of Laparoscopic Liver Resection in Korea
Joon Seong Park, Ho‐Seong Han, Dae Wook Hwang, Yoo‐Seok Yoon, Jai Young Cho, Yang‐Seok Koh, Choon Hyuck David Kwon, Kyung Sik Kim, Sang Bum Kim, Young-Hoon Kim, Hyung‐Chul Kim, Chong Woo Chu
SJR Q2Journal of Korean Medical ScienceOA

Since laparoscopic liver resection was first introduced in 2001, Korean surgeons have chosen a laparoscopic procedure as one of the treatment options for benign or malignant liver disease. We distributed and analyzed a nationwide questionnaire to members of the Korean Laparoscopic Liver Surgery Study Group (KLLSG) in order to evaluate the current status of laparoscopic liver resection in Korea. Questionnaires were sent to 24 centers of KLLSG. The questionnaire consisted of operative procedure, h

HepatologyMedicine

Research Areas

OncologySurgeryMolecular BiologyPulmonary and Respiratory MedicineInformation SystemsHepatology

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