Skip to main content

Jun-Nyoung Heo

Yonsei University · Medicine

About the Lab

Professor Jun-Nyoung Heo's research lab specializes in applying artificial intelligence and machine learning to improve clinical decision-making in acute cerebrovascular diseases, particularly ischemic stroke and COVID-19. The lab focuses on developing predictive models using readily available clinical data to forecast patient outcomes, intensive care needs, and treatment responses. Key research directions include outcome prediction, risk stratification, and diagnostic AI tools leveraging imaging and histopathologic data. The lab emphasizes real-world applicability, especially in resource-limited or high-acuity settings such as military hospitals and pandemic response systems.

stroke predictionAI in medicineCOVID-19 triagemachine learningclinical outcome prediction

Research Overview

Papers
94
Total Citations
1,421
Papers (5y)
66
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
66total
2022
2023
2024
2025
2026
Citations per year (5y)
482total
20222023202420252026

Selected Papers

15
1
Article|635 citations·2019
Machine Learning–Based Model for Prediction of Outcomes in Acute Stroke
JoonNyung Heo, Jihoon G. Yoon, Hyungjong Park, Young Dae Kim, Hyo Suk Nam, Ji Hoe Heo, Ji Hoe Heo, Ji Hoe Heo
SJR Q1StrokeOA

Background and Purpose- The prediction of long-term outcomes in ischemic stroke patients may be useful in treatment decisions. Machine learning techniques are being increasingly adapted for use in the medical field because of their high accuracy. This study investigated the applicability of machine learning techniques to predict long-term outcomes in ischemic stroke patients. Methods- This was a retrospective study using a prospective cohort that enrolled patients with acute ischemic stroke. Fav

EpidemiologyMedicine
2
Article|65 citations·2020
An Easy-to-Use Machine Learning Model to Predict the Prognosis of Patients With COVID-19: Retrospective Cohort Study
Hyung‐Jun Kim, Deokjae Han, Jeong-Han Kim, Daehyun Kim, Beomman Ha, Woong Seog, Yeon-Kyeng Lee, Dosang Lim, Sung Ok Hong, Mi-Jin Park, JoonNyung Heo
SJR Q1Journal of Medical Internet ResearchOA

BACKGROUND: Prioritizing patients in need of intensive care is necessary to reduce the mortality rate during the COVID-19 pandemic. Although several scoring methods have been introduced, many require laboratory or radiographic findings that are not always easily available. OBJECTIVE: The purpose of this study was to develop a machine learning model that predicts the need for intensive care for patients with COVID-19 using easily obtainable characteristics-baseline demographics, comorbidities, an

Infectious DiseasesMedicine
3
Article|41 citations·2021
Prediction of patients requiring intensive care for COVID-19: development and validation of an integer-based score using data from Centers for Disease Control and Prevention of South Korea
JoonNyung Heo, Deokjae Han, Hyung‐Jun Kim, Daehyun Kim, Yeon-Kyeng Lee, Dosang Lim, Sung Ok Hong, Mi-Jin Park, Beomman Ha, Woong Seog
SJR Q1Journal of Intensive CareOA

BACKGROUND: Unavailability or saturation of the intensive care unit may be associated with the fatality of COVID-19. Prioritizing the patients for hospitalization and intensive care may be critical for reducing the fatality of COVID-19. This study aimed to develop and validate a new integer-based scoring system for predicting patients with COVID-19 requiring intensive care, using only the predictors available upon triage. METHODS: This is a retrospective study using cohort data from the Korean C

Infectious DiseasesMedicine
4
Article|28 citations·2024
Radiomics using non-contrast CT to predict hemorrhagic transformation risk in stroke patients undergoing revascularization
JoonNyung Heo, Yongsik Sim, Byung Moon Kim, Dong Joon Kim, Young Dae Kim, Hyo Suk Nam, Yoon Seong Choi, Seung‐Koo Lee, Eung Yeop Kim, Beomseok Sohn
SJR Q1European Radiology
Radiology, Nuclear Medicine and ImagingMedicine
5
Article|18 citations·2020
COVID-19 Outcome Prediction and Monitoring Solution for Military Hospitals in South Korea: Development and Evaluation of an Application
JoonNyung Heo, Ji Ae Park, Deokjae Han, Hyung‐Jun Kim, Daeun Ahn, Beomman Ha, Woong Seog, Yu Rang Park
SJR Q1Journal of Medical Internet ResearchOA

BACKGROUND: COVID-19 has officially been declared as a pandemic, and the spread of the virus is placing sustained demands on public health systems. There are speculations that the COVID-19 mortality differences between regions are due to the disparities in the availability of medical resources. Therefore, the selection of patients for diagnosis and treatment is essential in this situation. Military personnel are especially at risk for infectious diseases; thus, patient selection with an evidence

Health Information ManagementHealth Professions
6
Review|17 citations·2025
Application of Artificial Intelligence in Acute Ischemic Stroke: A Scoping Review
JoonNyung Heo
SJR Q2NeurointerventionOA

Artificial intelligence (AI) is revolutionizing stroke care by enhancing diagnosis, treatment, and outcome prediction. This review examines 505 original studies on AI applications in ischemic stroke, categorized into outcome prediction, stroke risk prediction, diagnosis, etiology prediction, and complication and comorbidity prediction. Outcome prediction, the most explored category, includes studies predicting functional outcomes, mortality, and recurrence, often achieving high accuracy and outp

EpidemiologyMedicine
7
Article|17 citations·2023
Prediction of cerebral hemorrhagic transformation after thrombectomy using a deep learning of dual-energy CT
JoonNyung Heo, Youngno Yoon, Hyun Jin Han, Jung‐Jae Kim, Keun Young Park, Byung Moon Kim, Dong Joon Kim, Young Dae Kim, Hyo Suk Nam, Seung‐Koo Lee, Beomseok Sohn
SJR Q1European Radiology
EpidemiologyMedicine
8
Article|16 citations·2023
Cancer Prediction With Machine Learning of Thrombi From Thrombectomy in Stroke: Multicenter Development and Validation
JoonNyung Heo, Hyungwoo Lee, Young Seog, Sungeun Kim, Jang‐Hyun Baek, Hyungjong Park, Kwon–Duk Seo, Gyu Sik Kim, Han‐Jin Cho, Minyoul Baik, Joonsang Yoo, Jinkwon Kim
SJR Q1StrokeOA

BACKGROUND: We aimed to develop and validate machine learning models to diagnose patients with ischemic stroke with cancer through the analysis of histopathologic images of thrombi obtained during endovascular thrombectomy. METHODS: This was a retrospective study using a prospective multicenter registry which enrolled consecutive patients with acute ischemic stroke from South Korea who underwent endovascular thrombectomy. This study included patients admitted between July 1, 2017 and December 31

OncologyMedicine
9
Article|15 citations·2020
A Patient Self-Checkup App for COVID-19: Development and Usage Pattern Analysis
JoonNyung Heo, MinDong Sung, Sangchul Yoon, Jinkyu Jang, Wonwoo Lee, Deokjae Han, Hyung‐Jun Kim, Han‐Kyeol Kim, Ji Hyuk Han, Woong Seog, Beomman Ha, Yu Rang Park
SJR Q1Journal of Medical Internet ResearchOA

BACKGROUND: Clear guidelines for a patient with suspected COVID-19 infection are unavailable. Many countries rely on assessments through a national hotline or telecommunications, but this only adds to the burden of an already overwhelmed health care system. In this study, we developed an algorithm and a web application to help patients get screened. OBJECTIVE: This study aims to aid the general public by developing a web-based application that helps patients decide when to seek medical care duri

General Health ProfessionsHealth Professions
10
Article|12 citations·2024
Combined use of anticoagulant and antiplatelet on outcome after stroke in patients with nonvalvular atrial fibrillation and systemic atherosclerosis
JoonNyung Heo, Hyungwoo Lee, Il Hyung Lee, In Hwan Lim, Soon-Ho Hong, Joonggyeong Shin, Hyo Suk Nam, Young Dae Kim
SJR Q1Scientific ReportsOA

This study aimed to investigate whether there was a difference in one-year outcome after stroke between patients treated with antiplatelet and anticoagulation (OAC + antiplatelet) and those with anticoagulation only (OAC), when comorbid atherosclerotic disease was present with non-valvular atrial fibrillation (NVAF). This was a retrospective study using a prospective cohort of consecutive patients with ischemic stroke. Patients with NVAF and comorbid atherosclerotic disease were assigned to the

Cardiology and Cardiovascular MedicineMedicine
11
Article|11 citations·2023
Impact of Left Atrial or Left Atrial Appendage Thrombus on Stroke Outcome: A Matched Control Analysis
JoonNyung Heo, Hyungwoo Lee, Il Hyung Lee, Hyo Suk Nam, Young Dae Kim
SJR Q1Journal of StrokeOA

BACKGROUND AND PURPOSE: Left atrial or left atrial appendage (LA/LAA) thrombi are frequently observed during cardioembolic evaluation in patients with ischemic stroke. This study aimed to investigate stroke outcomes in patients with LA/LAA thrombus. METHODS: This retrospective study included patients admitted to a single tertiary center in Korea between January 2012 and December 2020. Patients with nonvalvular atrial fibrillation who underwent transesophageal echocardiography or multi-detector c

Cardiology and Cardiovascular MedicineMedicine
12
Article|10 citations·2022
Automated Composition Analysis of Thrombus from Endovascular Treatment in Acute Ischemic Stroke Using Computer Vision
JoonNyung Heo, Young Seog, Hyungwoo Lee, Il Hyung Lee, Sungeun Kim, Jang-Hyun Baek, Hyungjong Park, Kwon–Duk Seo, Gyu Sik Kim, Han‐Jin Cho, Minyoul Baik, Joonsang Yoo
SJR Q1Journal of StrokeOA
EpidemiologyMedicine
13
Article|9 citations·2018
Abstract 194: Machine Learning-Based Model Can Predict Stroke Outcome
JoonNyung Heo, Jihoon G. Yoon, Hyungjong Park, Young Dae Kim, Hyo Suk Nam, Ji Hoe Heo
SJR Q1Stroke

Introduction: Prediction of outcome in stroke patients can help both physicians and patients in making treatment decisions and managing prognostic expectations. Machine learning techniques are being increasingly used in the field of medical research. Hypothesis: We hypothesized that models developed with machine learning techniques are useful for predicting long-term functional outcomes in patients with acute ischemic stroke. Methods: The model was developed with a prospective cohort of acute is

EpidemiologyMedicine
14
Preprint|5 citations·2020
Prediction of patients requiring intensive care for COVID-19: development and validation of an integer-based score using data from Centers for Disease Control and Prevention of South Korea.
JoonNyung Heo, Deokjae Han, Hyung‐Jun Kim, Daehyun Kim, Yeon-Kyeng Lee, Dosang Lim, Sung Ok Hong, Mi-Jin Park, Beomman Ha, Woong Seog
Research SquareOA

Abstract Background Unavailability or saturation of the intensive care unit may be associated with the fatality of COVID-19. Prioritizing the patients for hospitalization and intensive care may be critical for reducing the fatality of COVID-19. This study aimed to develop and validate a new integer-based scoring system for predicting patients with COVID-19 requiring intensive care, using only the predictors available upon triage. Methods This is a retrospective study using cohort data from the K

Infectious DiseasesMedicine
15
Article|2 citations·2025
Automated ischemic stroke lesion detection on non-contrast brain CT: a large-scale clinical feasibility test AI stroke lesion detection on NCCT
JoonNyung Heo, Wi‐Sun Ryu, Jong‐Won Chung, Chi Kyung Kim, Joon-Tae Kim, Myung-Jae Lee, Dongmin Kim, Leonard Sunwoo, Johanna M. Ospel, Nishita Singh, Hee‐Joon Bae, Beom Joon Kim
SJR Q2Frontiers in NeuroscienceOA

Background Non-contrast CT (NCCT) is widely used imaging modality for acute stroke imaging but often fails to detect subtle early ischemic changes. Such underestimation can lead clinicians to overlook tissue-level information. This study aimed to develop and externally validate automated software for detecting ischemic lesions on NCCT and to assess its clinical feasibility in stroke patients undergoing endovascular thrombectomy. Methods In this retrospective, multicenter cohort study (May 2011–A

EpidemiologyMedicine

Research Areas

EpidemiologyCardiology and Cardiovascular MedicineRadiology, Nuclear Medicine and ImagingPulmonary and Respiratory MedicineNeurologyInfectious Diseases

Dive deeper into Jun-Nyoung Heo's research on Nubint

Open this lab's papers in the app to read with AI, summarize, and cite in your writing.