Jung Ho-Sam

AIMS: Effects of the blockade of renin-angiotensin system (RAS), by angiotensin-converting enzyme inhibitor (ACEi), type 1 angiotensin II receptor blocker (ARB), or a combination of both, were evaluated in Adriamycin (ADR)-induced glomerulopathy. METHODS: Male Sprague-Dawley rats (180-250 g) were induced of glomerulopathy by treatment with ADR (2 mg/kg, i.v.). Six weeks later, they were treated with cilazapril (1 mg/kg/day) and/or losartan (10 mg/kg/day) for an additional 6 weeks. RESULTS: The u

Laminin, a kind of multidomain glycoproteins, is mainly localized in the basement membranes of various tissues. It is known that laminin plays an important part in mammalian lung morphogenesis. The authors have undertaken this study to investigate the changes in the distribution of laminin, and to find out cells which synthesize laminin during the organogenesis and differentiation of the lung. The fetal and neoantal rats (Sprague-Dawley strain) were used as experimental animals. The immunohisto-

In order to investigating the pulmonary toxicity of the O-chlorobenzyledene malononitrile (CS), lacrimating agent, of CS was inhalated to Sprague-Dawley rats in the plastic chamber for 20 minutes. The ultrastructural changes of type II pneumocytes in the lung were observed with Hitachi 600 transmission electron microscope. The results obtained were as follows: 1. 3 hours after exposure to CS the fusion of surface microvilli, dilatation of cristernae of the rough endoplasmic reticulum, atrophy of

The ischemia and reperfusion injury of the skeletal muscles is caused by generation of reactive oxygen during ischemia and reperfusion. It is well known that over 4 hours of ischemia injures the skeletal muscles irreversibly. The author has demonstrated the effects of SOD (superoxide dismutase), DMTU (dimethyl thiourea) and ischemic preconditioning on ultrastructural changes of the muscle fibers in the rectus femoris muscles after 4 hours of ischemia and 1 day and 3 days of reperfusion. A total

Vincristine, a kind of anticancerous drugs, interferes with development of microtubles and synthesis of nucleic acid and proteins in cells, and destructs cytoplasmic membrane so that mitosis of cancer cells is inhibited. Unfortunately these anticancerous effects by vioneristime are not limited to specific cancer cells, so several side effects are produced. This study was performed to explore the effects of vincristine on the fine structure of cytoplasmic organelles and cartilagenous matrix in pr

세포 및 조직의 접합물질인 laminin은 신장의 신사구체 기저막을 구성하는 당단백 물질로 알려져 있으며, 상피조직, 신경조직 및 근육조직의 기저막에 분포되어 있어 조직내 세포의 재생, 극성 및 물질수용 동 필수적이고 미세한 역할을 한다고 보고되어 있다. 정상 신장에서는 제 4형 아교질, heparan sulfate proteoglycan 및 fibronectin 등과 함께 가시구조를 이루고 있다. 최근 많은 학자들은 여러 종류의 사구체질환에서 특히, membranous lupus nephriis, 막성증식성신사구체염, 사구체경화증 등에서 기저막내 laminin 의 분포가 변동된다고 주장한 바 있다. 이에 저자들은 신장에 독성이 큰 것으로 알려진 adriamycin을 실험동물에 투여하였을 때 신사구체기저막동에서 laminin의 분포 변동과 신사구체의 형태적 변화와의 관계 여부를 규명하고자 하였다. 본 실험에 사용한 실험동물은 SD계 체중 150g내외의 흰쥐로 대조군과 실험군으로 나뉘

Adriamycin is a one of anthracyclin antibiotics isolated from the culture media of Streptomyces peucetius var casius. The formation of reactive oxygen metabolite by redox cycling during the metabolism and the inhibition of DNA synthesis results in antineoplastic effects of adriamycin. The authors have demonstrated the effects of SOD(superoxide dismutase) or DMTU (dimethyl thiourea), which are used as an antioxidant, on the ultrastructural changes of the gastric chief cells after the administrati

Immunohistochemical and Electron Microscopic Study on the Depigmentation Effect of MelanostonHo-Sam Chung, Chul Oh1, Byung-Chan Kang1, Ho-Kwon Jung1