Junhee Seok

A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry new drug candidates forward into clinical trials. Systematic studies evaluating how well murine models mimic human inflammatory diseases are nonexistent. Here, we show that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses

In contemporary business landscapes, concerns about environmental, social, and governance (ESG) issues are increasingly prominent. Despite the rising public interest in ESG, empirical research assessing its efficacy remains sparse. This research investigates the subtle connection between ESG initiatives and firm value, highlighting the mediating role of customer satisfaction. Utilizing an industry-fixed effects model, our research analyzes an unbalanced panel dataset comprising 168 firms over fi

BACKGROUND: Understanding the transcriptional regulatory networks that map out the coordinated dynamic responses of signaling proteins, transcription factors and target genes over time would represent a significant advance in the application of genome wide expression analysis. The primary challenge is monitoring transcription factor activities over time, which is not yet available at the large scale. Instead, there have been several developments to estimate activities computationally. For exampl

Abstract The simulation and design of electronic devices such as transistors is vital for the semiconductor industry. Conventionally, a device is intuitively designed and simulated using model equations, which is a time-consuming and expensive process. However, recent machine learning approaches provide an unprecedented opportunity to improve these tasks by training the underlying relationships between the device design and the specifications derived from the extensively accumulated simulation d

Purpose This study clarifies the relationship between corporate social responsibility (CSR) news reports and firm value and identifies the mechanisms that constitute this relationship. Specifically, it identifies the roles of word of mouth (WOM) and traditional advertising in this relationship. Design/methodology/approach The data set used for the analysis covers 77 firms in Korea from 2012 to 2015. The random-effects model is applied to verify three hypotheses. Using a three-step regression ana

SUMMARY: High-throughput genome-wide studies of alternatively spliced mRNA transcripts have become increasingly important in clinical research. Consequently, easy-to-use software tools are required to process data from these studies, for example, using exon and junction arrays. Here, we introduce JETTA, an integrated software package for the calculation of gene expression indices as well as the identification and visualization of alternative splicing events. We demonstrate the software using dat

Mutual information, a general measure of the relatedness between two random variables, has been actively used in the analysis of biomedical data. The mutual information between two discrete variables is conventionally calculated by their joint probabilities estimated from the frequency of observed samples in each combination of variable categories. However, this conventional approach is no longer efficient for discrete variables with many categories, which can be easily found in large-scale biom

Conventional predictive Artificial Neural Networks (ANNs) commonly employ deterministic weight matrices; therefore, their prediction is a point estimate. Such a deterministic nature in ANNs causes the limitations of using ANNs for medical diagnosis, law problems, and portfolio management in which not only discovering the prediction but also the uncertainty of the prediction is essentially required. In order to address such a problem, we propose a predictive probabilistic neural network model, wh

Abstract Owing to the recent explosive expansion of deep learning, several challenging problems in a variety of fields have been handled by deep learning, yet deep learning methods have been limited in their application to the network estimation problem. While network estimation has a possibility to be a useful method in various domains, deep learning-based network estimation has a limitation in that the number of variables must be fixed and the estimation cannot be performed by convolutional la

High quality, comprehensive, and direct knowledge bases, when combined with appropriate bioinformatic algorithms, can significantly improve the discovery of gene regulatory relationships from high throughput gene expression data.

Abstract When designing new optical devices, many simulations must be conducted to determine the optimal design parameters. Therefore, fast and accurate simulations are essential for designing optical devices. In this work, we introduce a deep learning approach that accelerates a simulator solving frequency-domain Maxwell equations. Our model achieves high accuracy while predicting transmittance per wavelength in 2D slit arrays under certain conditions to achieve 160,000 times faster results tha