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Kyu Hoon Lee

Hanyang University · Medicine

About the Lab

Professor Kyu Hoon Lee's research lab specializes in musculoskeletal and rheumatic diseases, with a focus on spinal disorders, hand and upper limb rehabilitation, and the genetic underpinnings of inflammatory arthritis. The lab investigates clinical interventions such as forest bathing, botulinum toxin therapy, and tendon reconstruction to improve function and quality of life in patients with chronic pain and post-stroke conditions. It also conducts genetic studies, particularly genome-wide analyses of copy number variations in ankylosing spondylitis, to uncover disease mechanisms and biomarkers. The lab integrates clinical rehabilitation with molecular genetics to develop personalized, evidence-based treatment strategies.

ankylosing spondylitisupper limb rehabilitationspasticitygenetic variantstendon reconstruction

Research Overview

Papers
92
Total Citations
557
Papers (5y)
10
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
10total
2021
2022
2023
2024
2025
Citations per year (5y)
20total
20212022202320242025

Selected Papers

15
1
Article|42 citations·2015
Relief of Chronic Posterior Neck Pain Depending on the Type of Forest Therapy: Comparison of the Therapeutic Effect of Forest Bathing Alone Versus Forest Bathing With Exercise
Boram Kang, Taikon Kim, Mi Jung Kim, Kyu Hoon Lee, Seungyoung Choi, Dong Hun Lee, Hyo Ryoung Kim, Byol Jun, Seen Young Park, Sung Jae Lee, Si-Bog Park
SJR Q1Annals of Rehabilitation MedicineOA

When patients with chronic posterior neck pain underwent a short-term forest bathing (less than 7 days) program, FBE was more effective in the reduction of the number of TRPs than FBA. However, all other pain measurement scales we evaluated showed no statistically significant difference between the two protocols.

PharmacologyMedicine
2
Article|37 citations·2009
Tendon transfer or tendon graft for ruptured finger extensor tendons in rheumatoid hands
U. S. Chung, Jae‐Hoon Kim, Wan-Sik Seo, Kyu Hoon Lee
SJR Q1Journal of Hand Surgery (European Volume)OA

We evaluated the clinical outcome of tendon reconstruction using tendon graft or tendon transfer and the parameters related to clinical outcome in 51 wrists of 46 patients with rheumatoid arthritis with finger extensor tendon ruptures. At a mean follow-up of 5.6 years, the mean metacarpophalangeal (MP) joint extension lag was 8 degrees (range, 0-45) and the mean visual analogue satisfaction scale was 74 (range, 10-100). Clinical outcome did not differ significantly between tendon grafting and te

SurgeryMedicine
3
Article|35 citations·2014
Genome‐Wide Copy Number Variation Analysis Identifies Deletion Variants Associated With Ankylosing Spondylitis
Seung‐Hyun Jung, Seon‐Hee Yim, Hae‐Jin Hu, Kyu Hoon Lee, Joo‐Hyun Lee, Dong‐Hyuk Sheen, Mi‐Kyoung Lim, Soon‐Young Kim, Sung‐Won Park, Sohee Kim, Kyudong Han, Tae‐Hwan Kim
SJR Q1Arthritis & Rheumatology

OBJECTIVE: To identify ankylosing spondylitis (AS)-associated copy number variations (CNVs) in Korean subjects and their synergistic roles in the development of AS. METHODS: A genome-wide association study (GWAS) was performed in 309 patients with AS and 309 control subjects, using a copy number variant (CNV) microarray. AS-associated CNV regions were replicated in 2 independent sets (625 patients and 891 control subjects) by quantitative polymerase chain reaction (PCR) and deletion-typing PCR.

RheumatologyMedicine
4
Article|34 citations·2013
Spinal Mobility, Vertebral Squaring, Pulmonary Function, Pain, Fatigue, and Quality of Life in Patients With Ankylosing Spondylitis
Hyungpil Cho, Taikon Kim, Tae‐Hwan Kim, Seunghun Lee, Kyu Hoon Lee
SJR Q1Annals of Rehabilitation MedicineOA

This study shows that both reduced spinal mobility and radiographic changes in the vertebral body may have a predictive value for pulmonary impairment in patients with AS. Likewise, pain and perceived physical condition may play an important role in the QOL, functional capacity, and fatigue level of these patients.

RheumatologyMedicine
5
Article|31 citations·2018
Botulinum Toxin Injections and Electrical Stimulation for Spastic Paresis Improve Active Hand Function Following Stroke
Jong-Min Lee, Jean‐Michel Gracies, Si-Bog Park, Kyu Hoon Lee, Jiyeong Lee, Joon‐Ho Shin
SJR Q1ToxinsOA

Botulinum toxin type A (BTX-A) injections improve muscle tone and range of motion (ROM) among stroke patients with upper limb spasticity. However, the efficacy of BTX-A injections for improving active function is unclear. We aimed to determine whether BTX-A injections with electrical stimulation (ES) of hand muscles could improve active hand function (AHF) among chronic stroke patients. Our open-label, pilot study included 15 chronic stroke patients. Two weeks after BTX-A injections into the fin

NeurologyMedicine
6
Article|27 citations·2010
The effect of an arm sling on energy consumption while walking in hemiplegic patients: a randomized comparison
Seung Hoon Han, Taikon Kim, Seong Ho Jang, Mi Jung Kim, Si-Bog Park, Seoung Ic Yoon, Bong-Kun Choi, Michael Y. Lee, Kyu Hoon Lee
SJR Q1Clinical RehabilitationOA

OBJECTIVE: To evaluate the effect of an arm sling on gait speed and energy efficiency of patients with hemiplegia. DESIGN: A randomized crossover design. SETTING: A rehabilitation department of a university hospital. SUBJECTS: Thirty-seven outpatients with hemiplegia were included in this study. INTERVENTIONS: All patients walked on a 20-m walkway twice on the same day, randomly with and without an arm sling, at a self selected speed. MAIN MEASURES: The heart rate, gait speed, oxygen cost and ox

Physical Therapy, Sports Therapy and RehabilitationHealth Professions
7
Article|26 citations·2014
Correlations Between Electrically Quantified Pain Degree, Subjectively Assessed Visual Analogue Scale, and the McGill Pain Questionnaire: A Pilot Study
Jun‐Ho Kim, Kyung Soo Lee, Sang Won Kong, Taikon Kim, Mi Jung Kim, Si-Bog Park, Kyu Hoon Lee
SJR Q1Annals of Rehabilitation MedicineOA

Numerical values measured with PV showed consistent results with repeated calculations. Electrically measured QPD showed an excellent correlation with MPQ but not with VAS. These results demonstrate that PV is a significantly reliable device for quantifying the intensity of low back pain.

PharmacologyMedicine
8
Article|20 citations·2012
The relationship between peripheral arthritis and anti-cyclic citrullinated peptide antibodies in ankylosing spondylitis
Jin-Ok Kim, Ji‐Seon Lee, Ji‐Young Choi, Kyu Hoon Lee, Yong Bum Kim, Dae‐Hyun Yoo, Tae‐Hwan Kim
SJR Q2Joint Bone Spine
RheumatologyMedicine
9
Article|17 citations·2015
Change in Musculoskeletal Pain in Patients With Work-Related Musculoskeletal Disorder After Tailored Rehabilitation Education: A One-Year Follow-Up Survey
Dong Hun Lee, Boram Kang, Seungyoung Choi, Taikon Kim, Seong Ho Jang, Kyu Hoon Lee, Mi Jung Kim, Si-Bog Park, Seung Hoon Han
SJR Q1Annals of Rehabilitation MedicineOA

OBJECTIVE: To apply tailored rehabilitation education to video display terminal (VDT) workers with musculoskeletal pain and to assess changes in musculoskeletal pain after rehabilitation education. METHODS: A total of 8,828 VDT workers were screened for musculoskeletal disorders using a self-report questionnaire. Six hundred twenty-six VDT workers selected based on their questionnaires were enrolled in musculoskeletal rehabilitation education, which consisted of education on VDT syndrome and con

PharmacologyMedicine
10
Article|17 citations·2006
Cyclooxygenase-2 genotype and rheumatoid arthritis.
Kyu Hoon Lee, Hee Sang Kim, Ahmed El‐Sohemy, Marilyn C. Cornelis, Wan Sik Uhm, Sang‐Cheol Bae
PubMed

OBJECTIVE: To determine the association between cyclooxygenase-2 (COX-2) genotypes and risk and severity of rheumatoid arthritis (RA) in a Korean population. METHODS: A total of 258 Korean patients with RA and 400 control subjects were recruited from Hanyang University Hospital. Subjects were genotyped for the -765G/C polymorphism of the COX-2 gene by RFLP-PCR analysis. Odds ratios (OR) and 95% confidence intervals (CI) were calculated to estimate risk. Severity of RA was assessed by anatomical

PharmacologyMedicine
11
Article|16 citations·2011
Lack of association between promoter polymorphisms of HLA-G gene and rheumatoid arthritis in Korean population
S. K. Kim, Jin Hoon Chung, D. H. Kim, Dong Hwan Yun, Seung‐Jae Hong, Kyu Hoon Lee
SJR Q2Rheumatology International
ImmunologyImmunology and Microbiology
12
Article|15 citations·2017
Muscle Mass, Strength, Mobility, Quality of Life, and Disease Severity in Ankylosing Spondylitis Patients: A Preliminary Study
Seung Chan Kim, Yeong Guk Lee, Si-Bog Park, Tae‐Hwan Kim, Kyu Hoon Lee
SJR Q1Annals of Rehabilitation MedicineOA

OBJECTIVE: To determine if there is muscle mass reduction in patients with ankylosing spondylitis (AS) compared to the general population and to examine the relationship between skeletal muscle mass, quality of life (QOL), strength, and mobility in patients with AS. METHODS: A total of 30 AS patients were enrolled in this study. Skeletal muscle mass was measured by bioelectrical impedance analysis, and it was expressed as the skeletal muscle mass index (SMI). QOL was assessed using the EuroQOL (

RheumatologyMedicine
13
Article|15 citations·2011
Acute Retropharyngeal Calcific Tendinitis in an Unusual Location: a Case Report in a Patient with Rheumatoid Arthritis and Atlantoaxial Subluxation
Seunghun Lee, Kyung Bin Joo, Kyu Hoon Lee, Wan-Sik Uhm
SJR Q1Korean Journal of RadiologyOA

Retropharyngeal calcific tendinitis is defined as inflammation of the longus colli muscle and is caused by the deposition of calcium hydroxyapatite crystals, which usually involves the superior oblique fibers of the longus colli muscle from C1-3. Diagnosis is usually made by detecting amorphous calcification and prevertebral soft tissue swelling on radiograph, CT or MRI. In this report, we introduce a case of this disease which was misdiagnosed as a retropharyngeal tuberculous abscess, or a musc

Infectious DiseasesMedicine
14
Article|15 citations·2014
A randomized comparison of energy consumption when using different canes, inpatients after stroke
Yeon-Gyu Jeong, Yeon Jae Jeong, Taikon Kim, Seung Hoon Han, Seong Ho Jang, Yoon Shin Kim, Kyu Hoon Lee
SJR Q1Clinical Rehabilitation

OBJECTIVES: To investigate the differences in oxygen consumption associated with gait in hemiplegic patients according to the type of cane they use. DESIGN: A randomized crossover design. SETTING: University hospital-based rehabilitation center, Korea. SUBJECTS: Thirty consecutive patients (mean ± SD age, 56.3 ± 3.2 years) with chronic stroke, 17 (56.7%) males and 13 (43.3%) females. INTERVENTIONS: At approximately the same time of day for three consecutive days, each participant completed a wal

Physical Therapy, Sports Therapy and RehabilitationHealth Professions
15
Article|14 citations·2016
Comparison of Balance, Proprioception and Skeletal Muscle Mass in Total Hip Replacement Patients With and Without Fracture: A Pilot Study
Seunghwi Jo, Si-Bog Park, Mi Jung Kim, Taikon Kim, Kyeong Il Park, Junhyun Sung, Un Jin Park, Yee Suk Kim, Byeong-Jik Kang, Kyu Hoon Lee
SJR Q1Annals of Rehabilitation MedicineOA

OBJECTIVE: To determine whether there was a difference in balance, proprioception, and skeletal muscle mass among patients who undergo hip fracture surgery relative to and elective total hip replacement (THR). METHODS: Thirty-one THR patients were enrolled. The patients were categorized into two groups: fracture group (n=15) and non-fracture group (n=16). Berg Balance Scale (BBS) was used to balance the proprioception of the hip joint while a joint position sense (JPS) test was used to evaluate

SurgeryMedicine

Research Areas

Aerospace EngineeringRheumatologyPharmacologySurgeryRehabilitationOncology

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