Lee Hyun Kim

Background: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by arterial and venous thrombosis or pregnancy morbidity in patients with persistent antiphospholipid antibodies. However, nationwide population-based epidemiology studies regarding APS are still unavailable. Methods: We analyzed claims data extracted from the Korean Health Insurance and Review Agency (HIRA) covering more than 52 million Koreans, between January 1, 2008, and December 31, 2017. Patients di

The data regarding risk factors for death during tuberculosis (TB) treatment areinconsistent, and few studies examined this issue in Korea. The purpose of this study wasto evaluate baseline prognostic factors for death during treatment of adult patients withpulmonary TB in Korea. A multicenter retrospective cohort study of 2,481 patients whoreceived TB treatment at eight hospitals from January 2009 to December 2010 wasperformed. Successful treatment included cure (1,129, 45.5%) and treatment com

Purpose: Peramivir is the first intravenously administered neuramidase inhibitor for immediate delivery of an effective single-dose treatment in patients with influenza. However, limited data are available on intravenous (IV) peramivir treatment compared to oral oseltamivir for these patients. Materials and Methods: With a systematic review and meta-analysis, we compared the efficacy of IV peramivir with oral oseltamivirfor treatment of patients with seasonal influenza. MEDLINE, EMBASE, and Coch

Adding either macrolide or fluoroquinolone (FQ) to β-lactam has been recommended for patients with severe community-acquired pneumonia (CAP). However, due to the limited evidence available, there is a question as to the superiority of the two combination therapies. The MEDLINE, EMBASE, Cochrane Central Register, Scopus, and Web of Science databases were searched for systematic review and meta-analysis. A total of eight trials were analyzed. The total number of patients in the β-lactam plus macro

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia, which presents with a progressive worsening dyspnea, and thus a poor outcome. The members of the Korean Academy of Tuberculosis and Respiratory Diseases as well as the participating members of the Korea Interstitial Lung Disease Study Group drafted this clinical practice guideline for IPF management. This guideline includes a wide range of topics, including the epidemiology, pathogenesis, risk factors

The role of atypical bacteria and the effect of antibiotic treatments in acute bronchitis are still not clear. This study was conducted at 22 hospitals (17 primary care clinics and 5 university hospitals) in Korea. Outpatients (aged ≥ 18 yr) who had an acute illness with a new cough and sputum (≤ 30 days) were enrolled in 2013. Multiplex real-time polymerase chain reaction (RT-PCR) was used to detect five atypical bacteria. A total of 435 patients were diagnosed as having acute bronchitis (vs. p

저자들은 좌상엽 기관지를 막아 종양을 형성하여 폐암으로 오인된 기관지내 아스페르길루스증 1예를 경험하였기에 보고하는 바이다.

Cough is one of the most common symptom of many respiratory diseases. The Korean Academy of Tuberculosis and Respiratory Diseases organized cough guideline committee and cough guideline was developed by this committee. The purpose of this guideline is to help clinicians to diagnose correctly and treat efficiently patients with cough. In this article, we have stated recommendation and summary of Korean cough guideline. We also provided algorithm for acute, subacute, and chronic cough. For chronic

A rapid response to corticosteroid treatment and a generally favourable outcome are characteristic features of BOOP (Bronchiolitis obliterans organizing pneumonia). However, with increasing experience of the clinical spectrum of this disease, it is now recognized that some patients are refractory to steroid, which is associated with a poor prognosis. Here, two cases of BOOP initially treated with predinisone and antibiotics without effects, but subsequently responded to secondary cyclosporine tr

Purpose: Monoclonal antibodies against type 2 inflammatory pathways are currently promising therapeutics for severe asthma. The aim of this study was to determine how well type 2 (T2) inflammation-specific agents targeting interleukins reduce the rate ofasthma exacerbations (AE) in patients with severe asthma. Materials and Methods: We performed a systematic review and meta-analysis in accordance with PRISMA guidelines. A systematicliterature search was conducted in PubMed, Embase, and the Cochr

Background: The Korea Interstitial Lung Disease Study Group has made a new nationwide idiopathic pulmonary fibrosis (IPF) registry because the routine clinical practice has changed due to new guidelines and newly developed antifibrotic agents in the recent decade. The aim of this study was to describe recent clinical characteristics of Korean IPF patients.Methods: Both newly diagnosed and following IPF patients diagnosed after the previous registry in 2008 were enrolled. Survival analysis was on

Background: To evaluate chest CT findings of pandemic influenza A/H1N1 pneumonia without co-infection. Methods: Among 56 patients diagnosed with pandemic influenza A/H1N1 pneumonia, chest CT was obtained in 22 between October 2009 and Februrary 2010. Since two patients were co-infected with bacteria, the other twenty were evaluated. Predominant parenchymal patterns were categorized into consolidation, ground glass opacity (GGO), and mixed patterns. Distribution of parenchymal abnormalities was a

저자들은 좌상엽 기관지를 막아 종양을 형성하여 폐암으로 오인된 기관지내 아스페르길루스증 1예를 경험하였기에 보고하는 바이다.

Background: The purpose of this study was to assess the effect of our new video-assisted asthma education program on patients’ knowledge regarding asthma and asthma control. Methods: Adult asthmatics who were diagnosed by primary care physicians and followed for at least 1 year were educated via smart devices and pamphlets. The education sessions were carried out three times at 2-week intervals. Each education period lasted at most 5 minutes. The effectiveness was then evaluated using questionna

목 적:증가된 혈중 및 조직의 plasminogen activator inhibitor type 1 (PAI-1)은 심근 경색증을 포함한 다양한 혈관합병증의 발생과 관련이 있음이 보고되었고 최근에는 이러한 PAI- 1 유전자의 일부 다형성이 PAI-1 활성화와 관련되어 있다고 알려지었으나 아직 한국인 당뇨병의 합병증에 미치는 영향에 대해서는 연구가 미비한 실정이다. 이에 저자들은 PAI-1의 유전적 다양성이 한국인 당뇨병성 신부전 발생에 미치는 영향을 연구하였다. 방 법:경희대학교 의료원에 2형 당뇨병으로 10년 이상 등록된 환자 중 당뇨병 진단 후 20년 이내에 말기신부전증으로 진행한 92명 (남/여:28/64, 평균연령 61.2세)과 정상 신기능을 보이는 당뇨병 대조군 85명 (남/여:24/61, 평균연령 63.3세)을 대상으로 PAI-1 유전자의 다형성 중 promoter -675 부위의 4G/5G 다형성과 promoter -845 부위의 A/G 다형성을 비교하였다. 결 과: