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Lee-Ire Lee

Yonsei University · Medicine

About the Lab

Professor Lee-Ire Lee's research lab specializes in pediatric critical care and nephrology, with a focus on identifying novel biomarkers for early diagnosis of urinary tract infections and renal complications in children. The lab investigates systemic inflammatory and vascular disorders such as systemic capillary leak syndrome (SCLS) in oncology patients, aiming to improve clinical outcomes through better understanding of disease mechanisms and treatment responses. Key research directions include the role of acute-phase reactants like mean platelet volume (MPV) in pediatric infections and the impact of cancer therapies on rare but life-threatening conditions.

pediatric nephrologycapillary leak syndromeurinary tract infectionbiomarkers in childrenoncology complications

Research Overview

Papers
29
Total Citations
394
Papers (5y)
15
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
15total
2022
2023
2024
2025
2026
Citations per year (5y)
12total
20222023202420252026

Selected Papers

15
1
Review|79 citations·2017
Clinical Presentation, Management, and Prognostic Factors of Idiopathic Systemic Capillary Leak Syndrome: A Systematic Review
Tae Seong Eo, Kyung Ju Chun, Su Jung Hong, Ji Young Kim, I Re Lee, Keum Hwa Lee, Michael Eisenhut, Andreas Kronbichler, Jae Il Shin
SJR Q1The Journal of Allergy and Clinical Immunology In PracticeOA
SurgeryMedicine
2
Review|58 citations·2019
Incidence of Capillary Leak Syndrome as an Adverse Effect of Drugs in Cancer Patients: A Systematic Review and Meta-Analysis
Gwang Hun Jeong, Keum Hwa Lee, I Re Lee, Ji Hyun Oh, Dongwook Kim, Jae‐Won Shin, Andreas Kronbichler, Michael Eisenhut, Hans J. van der Vliet, Omar Abdel‐Rahman, Brendon Stubbs, Marco Solmi
SJR Q1Journal of Clinical MedicineOA

Capillary leak syndrome (CLS) is a rare disease with profound vascular leakage, which can be associated with a high mortality. There have been several reports on CLS as an adverse effect of anti-cancer agents and therapy, but the incidence of CLS according to the kinds of anti-cancer drugs has not been systemically evaluated. Thus, the aim of our study was to comprehensively meta-analyze the incidence of CLS by different types of cancer treatment or after bone marrow transplantation (BMT). We se

SurgeryMedicine
3
Article|58 citations·2016
Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection
Song Yi Han, I Re Lee, Se Jin Park, Ji Hong Kim, Jae Il Shin
Korean Journal of PediatricsOA

NLR can be used as a diagnostic marker of APN with DMSA defect, showing better results than those of conventional markers for VUR prediction.

Pediatrics, Perinatology and Child HealthMedicine
4
Review|54 citations·2016
Peripheral Brain-Derived Neurotrophic Factor Levels in Alzheimer’s Disease and Mild Cognitive Impairment: a Comprehensive Systematic Review and Meta-analysis
Bo Yi Kim, Seon Heui Lee, Petra L. Graham, Francesco Angelucci, Alejandro Lucía, Hélios Pareja-Galeano, Thomas Leyhe, Yuda Turana, I Re Lee, Ji Hye Yoon, Jae Il Shin
SJR Q1Molecular NeurobiologyOA
Cellular and Molecular NeuroscienceNeuroscience
5
Review|41 citations·2021
Changes in undergraduate medical education due to COVID-19: a systematic review.
I Re Lee, Hae Won Kim, Y Lee, Ai Koyanagi, Louis Jacob, Shinki An, Jae Il Shin, Lee Smith
PubMedOA

OBJECTIVE: This study aims to provide medical educators with insights into the current status and prospects of undergraduate medical education, which has been affected by the COVID-19 pandemic. MATERIALS AND METHODS: We conducted a database search of PubMed, Embase, and ERIC and identified articles on COVID-19-related undergraduate medical education. We independently reviewed titles and abstracts and extracted data on the geographic location of the study, area of specialty, phase in medical scho

Clinical PsychologyPsychology
6
Article|37 citations·2015
Mean platelet volume in young children with urinary tract infection
I Re Lee, Jae Il Shin, Se Jin Park, Ji Young Oh, Ji Hong Kim
SJR Q1Scientific ReportsOA

Mean platelet volume (MPV) has not yet been well-established in urinary tract infection (UTI). The purpose of this study was to evaluate the role of MPV as an acute phase reactant in children with UTI. Data from 118 young children (<2 years) with UTI between 2012 and 2013 were grouped as acute pyelonephritis (APN) and lower UTI according to the dimercaptosuccinic acid (DMSA) scan abnormalities. MPV, platelet distribution width (PDW) platelet count, and other infection markers (white blood cell [

Pediatrics, Perinatology and Child HealthMedicine
7
Review|32 citations·2018
Systemic Capillary Leak Syndrome (Clarkson Syndrome) in Cancer Patients: A Systematic Review
Jae Il Shin, Jae Il Shin, Keum Hwa Lee, I Re Lee, Ji Hyun Oh, Dong Wook Kim, Jae Won Shin, Jae‐Won Shin, Tae Seong Eo, Andreas Kronbichler, Michael Eisenhut, Hans J. Van der Vliet
SJR Q1Journal of Clinical MedicineOA

Systemic capillary leak syndrome (SCLS) is a rare disease characterized by shock caused by capillary hyperpermeability. The disease can occur in cancer patients and effective therapeutic strategies have not been established yet. The aim of the study was to analyze the clinical and laboratory data, treatment modalities, and mortality rate of patients and to identify contributing factors leading to mortality of SCLS in cancer. We searched MEDLINE (inception to July 2018) and of 4612 articles, we i

SurgeryMedicine
8
Article|17 citations·2016
Hypertensive crisis in children: an experience in a single tertiary care center in Korea
Keum Hwa Lee, I Re Lee, Se Jin Park, Ji Hong Kim, Ji Young Oh, Jae Il Shin
SJR Q1Clinical HypertensionOA

Close blood pressure monitoring and careful examinations should be mandatory in children with underlying disease, especially renal diseases and cancer. Furthermore, both nicardipine and labetalol may be effective antihypertensive drug in lowering high blood pressure in children with hypertensive crisis.

Cardiology and Cardiovascular MedicineMedicine
9
Article|9 citations·2022
An analysis of student essays on medical leadership and its educational implications in South Korea
I Re Lee, Hanna Jung, Yewon Lee, Jae Il Shin, Shinki An
SJR Q1Scientific ReportsOA

To examine medical students' perceptions of leadership and explore their implications for medical leadership education. We conducted a qualitative analysis of the essays submitted by students in the medical leadership course from 2015 to 2019. We categorised the essays by the characteristics of the selected model leaders (N = 563) and types of leadership (N = 605). A statistically significant proportion of students selected leaders who were of the same gender as themselves (P < 0.001), graduate

Public Health, Environmental and Occupational HealthMedicine
10
Article|3 citations·2021
Medical Educators’ Response to Changes in Medical Education due to COVID‐19
I Re Lee, Hanna Jung, Yewon Lee, Jae Il Shin, Shinki An
Korean Medical Education ReviewOA

To analyze medical professors’ evaluation of their online education experiences in an attempt to support faculty members and indicate the future direction of medical education. Faculty members who taught online in the first semester of 2020 at Yonsei University College of Medicine in South Korea were surveyed. The results of the survey were analyzed in June 2020. There were 88 respondents (35.1% of 251): 59 professors (67.0%), 16 associate professors (18.2%), and 13 assistant professors (14.8%).

Information SystemsComputer Science
11
Article|2 citations·2015
Hyponatremia May Reflect Severe Inflammation in Children with Kawasaki Disease
I Re Lee, Se Jin Park, Ji Young Oh, Gwang Cheon Jang, Uria Kim, Jae Il Shin, Kee Hyuck Kim
SJR Q4Childhood Kidney DiseasesOA

The aim of the present study was to investigate the risk factors for the development of coronary artery lesions (CALs) and to determine whether hyponatremia is associated with CALs in children with Kawasaki disease (KD). Methods: We retrospectively analyzed the data of 105 children with KD who were admitted to Ilsan Hospital between January 2000 and July 2011. Results: Erythrocyte sedimentation rate (P = 0.013), total bilirubin levels (P = 0.017) were higher and serum sodium levels (P = 0.027) w

SurgeryMedicine
12
Article|2 citations·2022
Design of a Model to Structure Longitudinal Data for Medical Education Based on the I-E-O Model
Hanna Jung, I Re Lee, Hae Won Kim, Shinki An
Korean Medical Education ReviewOA

The purpose of this study was to establish a model for constructing longitudinal data for medical school, and to structure cohort and longitudinal data using data from Yonsei University College of Medicine (YUCM) according to the established input-environment-output (I-E-O) model. The study was conducted according to the following procedure. First, the data that YUCM has collected was reviewed through data analysis and interviews with the person in charge of each questionnaire. Second, the opini

Public Health, Environmental and Occupational HealthMedicine
13
Article|1 citations·2026
Cross-Population Validation of the Pediatric CKD Risk-Prediction Tool
Peong Gang Park, J W Kim, Naye Choi, Ji Hyun Kim, Seon Hee Lim, Joo Hoon Lee, Min Ji Park, Hee Sun Baek, Min Hyun Cho, I Re Lee, Jae Il Shin, Kyoung Hee Han
SJR Q1Kidney International ReportsOA

Introduction This study aimed to externally validate the performance of the kidney replacement therapy risk prediction calculator for chronic kidney disease in children in an ethnically distinct East Asian population. Methods We externally validated the kidney replacement therapy risk prediction calculator for chronic kidney disease in children using data from the KoreaN Cohort Study on Outcomes in Pediatric Chronic Kidney Disease. Six parametric survival models from the generalized gamma family

NephrologyMedicine
14
Review|1 citations·2020
A Critical Review of Medical Humanities Education Curriculum Development Based on Kern’s Curriculum Development Model
I Re Lee, Shinki An
Korean Medical Education ReviewOA

Medical humanities education (MHE) is as essential as basic medical sciences and clinical medicine education. Despite the importance of MHE, MHE curriculum development (CD) has proven to be challenging. This critical review examines the MHE CD at one medical school. The critical review methodology was developed based on Kern’s six step CD model to systematically examine the CD of “Doctoring and Medical Humanities (DMH)” at the Yonsei University College of Medicine. Five review questions were dev

Public Health, Environmental and Occupational HealthMedicine
15
Article|0 citations·2021
Medical Educators’ Response to Changes in Medical Education due to COVID‐19
이이레, 정한나, 이예원, 김혜원, 신재일, 안신기
http://www.kmer.or.kr/pds/journal/thesis/20211101093927-GOQZW.pdf

To analyze medical professors’ evaluation of their online education experiences in an attempt to support faculty members and indicate the future direction of medical education. Faculty members who taught online in the first semester of 2020 at Yonsei University College of Medicine in South Korea were surveyed. The results of the survey were analyzed in June 2020. There were 88 respondents (35.1% of 251): 59 professors (67.0%), 16 associate professors (18.2%), and 13 assistant professors (14.8%).

Research Areas

SurgeryPublic Health, Environmental and Occupational HealthNephrologySociology and Political SciencePediatrics, Perinatology and Child HealthCellular and Molecular Neuroscience

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