Min-sun Cho

Mer signaling participates in a novel inhibitory pathway in TLR activation. The purpose of the present study was to examine the role of Mer signaling in the down-regulation of TLR4 activation-driven immune responses in mice, i.t.-treated with LPS, using the specific Mer-blocking antibody. At 4 h and 24 h after LPS treatment, expression of Mer protein in alveolar macrophages and lung tissue decreased, sMer in BALF increased significantly, and Mer activation increased. Pretreatment with anti-Mer a

Src tyrosine kinases (TKs) are signaling proteins involved in cell signaling pathways toward cytoskeletal, membrane and nuclear targets. In the present study, using a selective Src TK inhibitor, PP1, we investigated the roles of Src TKs in the key pulmonary responses, NF-kappaB activation, and integrin signaling during acute lung injury in BALB/C mice intratracheally treated with LPS. LPS resulted in c-Src phosphorylation in lung tissue and the phospho-c-Src was predominantly localized in recrui

Background: The aim of study was to determine the relative frequency of malignant lymphoma according to World Health Organization (WHO) classification in Korea. Methods: A total of 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site of involvement and immunophenotypes were obtained. Results: The relative frequency of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) was 95.4% and 4.6%, respectively. B-cell l

Rheumatoid vasculitis is a rare, but most serious extra-articular complications of long-standing, seropositive rheumatoid arthritis (RA). Vasculitis of hepatic artery is an extremely rare but severe manifestation of rheumatoid vasculitis. A 72-year-old woman who presented with polyarthralgia for 2 months was diagnosed with early RA. Since she had manifestations of livedo reticularis, and liver dysfunction which was atypical for RA patients, a percutaneous needle liver biopsy was performed reveal

We suggest that primary or total tumor burden, solid adenocarcinoma morphology, tumor necrosis, and frequent mitosis could predict ctDNA shedding in pulmonary adenocarcinoma.

High-mobility group box 1 (HMGB1), an abundant nuclear protein that triggers host immune responses, is an endogenous danger signal involved in the pathogenesis of various infectious agents. However, its role in hepatitis C virus (HCV) infection is not known. Here, we show that HMGB1 protein is translocated from the nucleus to cytoplasm and subsequently is released into the extracellular milieu by HCV infection. Secreted HMGB1 triggers antiviral responses and blocks HCV infection, a mechanism tha

BACKGROUND: Although altered levels of adiponectin have been reported as a potential risk factor in colorectal cancer (CRC), the importance of the role played by adiponectin in colorectal carcinogenesis has not been established. We sought to examine the expression pattern of adiponectin and adiponectin receptors (AdipoRs) in the normal-adenoma-carcinoma sequence and to assess the implications of adiponectin in colorectal carcinogenesis. METHODS: Serum adiponectin concentrations, and the mRNA and

Abstract Context. —Kikuchi disease is a self-limiting febrile lymphadenopathy characterized by a patchy area of apoptosis. Kikuchi disease is thought to be caused by a virus, but this has not been clearly demonstrated. Human herpesviruses 6 and 7 (HHV-6 and HHV-7) are lymphotropic viruses that can induce apoptosis in infected lymphocytes. Recently, HHV-8 was reported to be a possible etiologic agent of Kikuchi disease. Objective. —To investigate the incidence of HHV-6, HHV-7, and HHV-8 infection

본 논문은 아이돌 콘텐츠의 트랜스미디어 스토리텔링 방식을 EXO와 BTS 콘텐츠를 중심으로 서사적, 매체적 측면에서 분석하였다. 서사적 측면에서 EXO는 로망스 양식의 캐릭터를 재현하며 현실과 분리된 초인으로 형상화된다. 반면 BTS는 하위모방 양식의 캐릭터를 재현하며 문제적 현실을 반영하는 대리자로 형상화된다. 이러한 재현 방식은 사용자를 서사에 몰입시키고, 캐릭터에 몰입하는 과정을 통해 사용자는 문제적 현실로부터 형성된 불안을 해소한다. 한편 두 콘텐츠는 다양한 매체를 활용하여 파편화된 서사를 제공한다. 팬덤은 이야기 파편들을 적극적으로 연결함으로써 서사를 완성시키며, 나아가 아이돌 콘텐츠의 스토리월드를 구축하고 확장한다. 이때 팬덤은 관심사를 중심으로 결집한 소규모 집단들로 구성되어있다. 팬덤 내 다양한 목소리는 스토리월드 구축에 반영되기 때문에 아이돌 콘텐츠의 스토리월드는 필연적으로 다성적이며, 끊임없이 확장된다.

본 연구는 오픈 월드 기반 어드벤처 게임에 나타난 포스트휴먼적 특징과 그 의미를 분석했다. 오픈 월드 기반 어드벤처 게임은 플레이어 캐릭터의 비인간적 신체와 정보의 제약을 통해 포스트휴먼 주체를 재현한다. 이때 비선형적인 오픈 월드의 특성에 따라 플레이어는 퀘스트 수행을 위해 모든 공간을 면밀히 탐색하고 이를 반복한다. 더불어 플레이어가 수행 가능한 상호작용은 갈등과 충돌이 아닌 이동, 문제 해결, 커뮤니케이션으로 제한되며 이러한 제약은 플레이를 진행해야만 파악 가능하다. 이처럼 플레이어는 포스트휴먼 주체가 되는 사건을 단계적으로 경험한다. 이를 통해 플레이어는 혼종적 주체성을 체현하고 나아가 인간과 비인간의 공존에 대한 존재론적 사유를 시도하게 된다.

Background : Regulatory T cells (Tregs) may contribute to the immunological hyporesponsiveness against hepatitis B virus (HBV), and this can result in chronic infection. Tregs suppress the T cell responses directed against HBV and they protect hepatocytes by down-regulating the immune responses that cause liver damage, but the role of Tregs has not been well characterized. Methods : Fifty four patients were selected and classified into three groups (12 were in the immune-tolerance phase, 35 were

Objectives DNA methylation of promoter-associated CpG islands is an epigenetic modification of DNA associanted with gene silencing. p73 is a member of the p 53 family which is a tumor suppressor gene producing apoptosis and cell cycel arrest. We investigated the methylation pattern of p73 on the cases diagnosed at Ewha university hospital between 1993-2002. Material and Methods Sixteen cases of NK/T cell lymphomas and 7 cases of normal controls, which were 2 cases of peripheral blood mononuclear