Minsup Sim
Sungkyunkwan University · Medicine
About the Lab
Professor Minsup Sim's research lab specializes in critical care medicine, with a primary focus on improving outcomes in patients with life-threatening conditions such as cardiac arrest, sepsis, and shock. The lab investigates hemodynamic and metabolic markers—such as lactate levels, ScvO2, and extracorporeal life support—to predict neurological outcomes and guide resuscitation strategies. Key research directions include optimizing therapeutic hypothermia protocols, evaluating compliance with sepsis resuscitation bundles, and assessing long-term skill retention in basic life support among medical trainees. The lab emphasizes evidence-based, protocol-driven interventions in emergency and critical care settings.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15OBJECTIVE: We investigated whether the survival of patients with inhospital cardiac arrest could be extended by extracorporeal cardiopulmonary resuscitation supported with extracorporeal membrane oxygenation compared with those of conventional cardiopulmonary resuscitation. DESIGN: : A retrospective, single-center, observational study. SETTING: A tertiary care university hospital. PATIENTS: We retrospectively analyzed a total of 406 adult patients with witnessed inhospital cardiac arrest receivi
INTRODUCTION: Several methods have been proposed to evaluate neurological outcome in out-of-hospital cardiac arrest (OHCA) patients. Blood lactate has been recognized as a reliable prognostic marker for trauma, sepsis, or cardiac arrest. The objective of this study was to examine the association between initial lactate level or lactate clearance and neurologic outcome in OHCA survivors who were treated with therapeutic hypothermia. METHODS: This retrospective cohort study included patients who u
Oxygenation category, as represented by initial Scvo2 and lactate levels, was significantly associated with 28-day mortality in patients with severe sepsis or septic shock. Associations between Scvo2 ≥70% and 28-day survival were observed only in patients without severe lactic acidosis.
The Surviving Sepsis Campaign guidelines recommend implementing a 6-h resuscitation bundle, which has been associated with reduced mortality of patients presenting with severe sepsis or septic shock. However, this resuscitation bundle has not yet become a widely implemented treatment protocol. It is still unclear what factors are associated with the rate of compliance with the resuscitation bundle. In this study, we evaluated the potential factors associated with implementation and compliance of
OBJECTIVE: To investigate the level of basic life support (BLS) skill retention of medical interns 6 and 12 months after BLS education and analyse the correlation between clinical experience of cardiopulmonary resuscitation (CPR) and BLS skill retention. MATERIALS AND METHODS: The baseline performance of BLS skills in medical doctors during their internship was tested immediately after the BLS provider course. The subjects were divided into two groups, which were tested using the same method aft
We aimed to compare outcomes of sepsis patients according to their hemodynamic presentation: cryptic shock (CS), cryptic to overt shock (COS), and overt shock (OS). We analyzed the sepsis registry for adult patients who presented to the emergency department (ED) of a tertiary hospital and met the criteria for severe sepsis or septic shock between August 2008 and March 2012. We classified the patients as having CS, COS, or OS. "Cryptic shock" was defined as severe sepsis with a lactate level of 4
OBJECTIVES: We describe our 3-year experience with endotracheal intubation (ETI) outcomes during a multidisciplinary emergency department (ED)-based quality improvement (QI) program. METHODS: This was a single-center, observational study taking place during a QI program. We used a registry for airway management performed in the ED from April 2014 to February 2017. The QI program focused on procedural standardization, airway management education, and comprehensive preparation of airway equipment.
Traditional BLS training is less effective in individuals aged >or=40 years.
Survivors of out-of-hospital cardiac arrest (OHCA) have high mortality and morbidity. An acute coronary event is the most common cause of sudden cardiac death. For this reason, coronary angiography is an important diagnostic and treatment strategy for patients with postcardiac arrest. This study aimed to identify the correlation between postreturn of spontaneous circulation (ROSC) on an electrocardiogram (ECG) and results of coronary angiography of OHCA survivors.We collected data from our OHCA
Objective. We conducted this study to evaluate the clinical outcomes of patients with severe sepsis and septic shock who were treated with ketamine for endotra-cheal intubation.Methods. A single-center, retrospective study was carried out to compare the out-comes of patients with severe sepsis and septic shock who received a ketamine or non-ketamine agent for rapid sequence intubation (RSI). We analyzed the sepsis registry for adult patients who presented to the emergency department (ED), met th
Research Areas
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