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Minsup Sim

Sungkyunkwan University · Medicine

About the Lab

Professor Minsup Sim's research lab specializes in critical care medicine, with a primary focus on improving outcomes in patients with life-threatening conditions such as cardiac arrest, sepsis, and shock. The lab investigates hemodynamic and metabolic markers—such as lactate levels, ScvO2, and extracorporeal life support—to predict neurological outcomes and guide resuscitation strategies. Key research directions include optimizing therapeutic hypothermia protocols, evaluating compliance with sepsis resuscitation bundles, and assessing long-term skill retention in basic life support among medical trainees. The lab emphasizes evidence-based, protocol-driven interventions in emergency and critical care settings.

cardiac arrestsepsislactateresuscitationcritical care

Research Overview

Papers
167
Total Citations
2,624
Papers (5y)
27
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
27total
2021
2022
2023
2024
2025
Citations per year (5y)
149total
20212022202320242025

Selected Papers

15
1
Article|417 citations·2010
Extracorporeal cardiopulmonary resuscitation in patients with inhospital cardiac arrest: A comparison with conventional cardiopulmonary resuscitation*
Tae Gun Shin, Jin‐Ho Choi, Ik Joon Jo, Min Seob Sim, Hyoung Gon Song, Yeon Kwon Jeong, Yong-Bien Song, Joo‐Yong Hahn, Seung‐Hyuk Choi, Hyeon‐Cheol Gwon, Eun‐Seok Jeon, Kiick Sung
SJR Q1Critical Care Medicine

OBJECTIVE: We investigated whether the survival of patients with inhospital cardiac arrest could be extended by extracorporeal cardiopulmonary resuscitation supported with extracorporeal membrane oxygenation compared with those of conventional cardiopulmonary resuscitation. DESIGN: : A retrospective, single-center, observational study. SETTING: A tertiary care university hospital. PATIENTS: We retrospectively analyzed a total of 406 adult patients with witnessed inhospital cardiac arrest receivi

Emergency MedicineMedicine
2
Article|230 citations·2016
Neutrophil-to-lymphocyte ratio as a prognostic marker in critically-ill septic patients
Sung Yeon Hwang, Tae Gun Shin, Ik Joon Jo, Kyeongman Jeon, Gee Young Suh, Tae Rim Lee, Hee Yoon, Won Chul, Min Seob Sim
SJR Q1The American Journal of Emergency Medicine
EpidemiologyMedicine
3
Article|167 citations·2013
Two-year survival and neurological outcome of in-hospital cardiac arrest patients rescued by extracorporeal cardiopulmonary resuscitation
Tae Gun Shin, Ik Joon Jo, Min Seob Sim, Yong-Bien Song, Jung-Hoon Yang, Joo‐Yong Hahn, Seung‐Hyuk Choi, Hyeon‐Cheol Gwon, Eun‐Seok Jeon, Kiick Sung, Young Tak Lee, Jin‐Ho Choi
SJR Q1International Journal of Cardiology
Emergency MedicineMedicine
4
Article|71 citations·2013
Better lactate clearance associated with good neurologic outcome in survivors who treated with therapeutic hypothermia after out-of-hospital cardiac arrest
Tae Rim Lee, Mun Ju Kang, Won Chul Cha, Tae Gun Shin, Min Seob Sim, Ik Joon Jo, Keun Jeong Song, Yeon Kwon Jeong, Jun Hwi Cho
SJR Q1Critical CareOA

INTRODUCTION: Several methods have been proposed to evaluate neurological outcome in out-of-hospital cardiac arrest (OHCA) patients. Blood lactate has been recognized as a reliable prognostic marker for trauma, sepsis, or cardiac arrest. The objective of this study was to examine the association between initial lactate level or lactate clearance and neurologic outcome in OHCA survivors who were treated with therapeutic hypothermia. METHODS: This retrospective cohort study included patients who u

Emergency MedicineMedicine
5
Article|62 citations·2016
Better prognostic value with combined optic nerve sheath diameter and grey-to-white matter ratio on initial brain computed tomography in post-cardiac arrest patients
Minjung Kathy Chae, Eunsil Ko, Jeong Hoon Lee, Tae Rim Lee, Hee Yoon, Sung Yeon Hwang, Won Chul, Tae Gun Shin, Min Seob Sim, Ik Joon Jo, Keun Jeong Song, Joong Eui Rhee
SJR Q1Resuscitation
NeurologyMedicine
6
Article|62 citations·2015
Comprehensive Interpretation of Central Venous Oxygen Saturation and Blood Lactate Levels During Resuscitation of Patients With Severe Sepsis and Septic Shock in the Emergency Department
Tae Gun Shin, Ik Joon Jo, Sung Yeon Hwang, Kyeongman Jeon, Gee Young Suh, Euna Choe, Young Kun Lee, Tae Rim Lee, Won Chul, Min Seob Sim
SJR Q1Shock

Oxygenation category, as represented by initial Scvo2 and lactate levels, was significantly associated with 28-day mortality in patients with severe sepsis or septic shock. Associations between Scvo2 ≥70% and 28-day survival were observed only in patients without severe lactic acidosis.

EpidemiologyMedicine
7
Article|58 citations·2012
Factors Influencing Compliance With Early Resuscitation Bundle in the Management of Severe Sepsis and Septic Shock
Mun Ju Kang, Tae Gun Shin, Ik Joon Jo, Kyeongman Jeon, Gee Young Suh, Min Seob Sim, So Yeon Lim, Keun Jeong Song, Yeon Kwon Jeong
SJR Q1Shock

The Surviving Sepsis Campaign guidelines recommend implementing a 6-h resuscitation bundle, which has been associated with reduced mortality of patients presenting with severe sepsis or septic shock. However, this resuscitation bundle has not yet become a widely implemented treatment protocol. It is still unclear what factors are associated with the rate of compliance with the resuscitation bundle. In this study, we evaluated the potential factors associated with implementation and compliance of

EpidemiologyMedicine
8
Article|47 citations·2012
The duration of acute health problems in people involved with the cleanup operation of the Hebei Spirit oil spill
Ji Ung Na, Min Seob Sim, Ik Joon Jo, Hyoung Gon Song
SJR Q1Marine Pollution Bulletin
PollutionEnvironmental Science
9
Article|26 citations·2011
Basic life support skill retention of medical interns and the effect of clinical experience of cardiopulmonary resuscitation
Ji Ung Na, Min Seob Sim, Ik Joon Jo, Hyoung Gon Song, Keun Jeong Song
SJR Q1Emergency Medicine Journal

OBJECTIVE: To investigate the level of basic life support (BLS) skill retention of medical interns 6 and 12 months after BLS education and analyse the correlation between clinical experience of cardiopulmonary resuscitation (CPR) and BLS skill retention. MATERIALS AND METHODS: The baseline performance of BLS skills in medical doctors during their internship was tested immediately after the BLS provider course. The subjects were divided into two groups, which were tested using the same method aft

Emergency MedicineMedicine
10
Article|22 citations·2014
Association Between Hemodynamic Presentation and Outcome in Sepsis Patients
Sung Yeon Hwang, Tae Gun Shin, Ik Joon Jo, Kyeongman Jeon, Gee Young Suh, Tae Rim Lee, Won Chul, Min Seob Sim, Keun Jeong Song, Yeon Kwon Jeong
SJR Q1Shock

We aimed to compare outcomes of sepsis patients according to their hemodynamic presentation: cryptic shock (CS), cryptic to overt shock (COS), and overt shock (OS). We analyzed the sepsis registry for adult patients who presented to the emergency department (ED) of a tertiary hospital and met the criteria for severe sepsis or septic shock between August 2008 and March 2012. We classified the patients as having CS, COS, or OS. "Cryptic shock" was defined as severe sepsis with a lactate level of 4

EpidemiologyMedicine
11
Article|18 citations·2018
Quality Improvement Program Outcomes for Endotracheal Intubation in the Emergency Department
Sung Yeon Hwang, Joo Hyun Park, Hee Yoon, Won Chul Cha, Ik Joon Jo, Min Seob Sim, Keun Jeong Song, Hyo Jung Woo, Sung Geun Jeong, Tae Gun Shin
SJR Q1Journal of Patient Safety

OBJECTIVES: We describe our 3-year experience with endotracheal intubation (ETI) outcomes during a multidisciplinary emergency department (ED)-based quality improvement (QI) program. METHODS: This was a single-center, observational study taking place during a QI program. We used a registry for airway management performed in the ED from April 2014 to February 2017. The QI program focused on procedural standardization, airway management education, and comprehensive preparation of airway equipment.

Anesthesiology and Pain MedicineMedicine
12
Article|11 citations·2009
Basic cardiac life support education for non-medical hospital employees
Min Seob Sim, Ik Joon Jo, Hyoung Gon Song
SJR Q1Emergency Medicine Journal

Traditional BLS training is less effective in individuals aged >or=40 years.

Emergency MedicineMedicine
13
Article|10 citations·2015
Early central diabetes insipidus: An ominous sign in post–cardiac arrest patients
Minjung Kathy Chae, Jeong Hoon Lee, Tae Rim Lee, Hee Yoon, Sung Yeon Hwang, Won Chul, Tae Gun Shin, Min Seob Sim, Ik Joon Jo, Keun Jeong Song, Joong Eui Rhee, Yeon Kwon Jeong
SJR Q1Journal of Critical Care
Emergency MedicineMedicine
14
Article|10 citations·2017
Role of coronary angiography for out-of-hospital cardiac arrest survivors according to postreturn of spontaneous circulation on an electrocardiogram
Tae Rim Lee, Sung Yeon Hwang, Won Chul, Tae Gun Shin, Min Seob Sim, Ik Joon Jo, Keun Jeong Song, Joong Eui Rhee, Yeon Kwon Jeong
SJR Q3MedicineOA

Survivors of out-of-hospital cardiac arrest (OHCA) have high mortality and morbidity. An acute coronary event is the most common cause of sudden cardiac death. For this reason, coronary angiography is an important diagnostic and treatment strategy for patients with postcardiac arrest. This study aimed to identify the correlation between postreturn of spontaneous circulation (ROSC) on an electrocardiogram (ECG) and results of coronary angiography of OHCA survivors.We collected data from our OHCA

Emergency MedicineMedicine
15
Article|6 citations·2018
Ketamine use for endotracheal intubation in severe sepsis and septic shock
SEOK WOO JO, SUNG YEON HWANG, Ik Joon Jo, T.R. Lee, Hee Yoon, WON CHUL CHA, Min Seob Sim, Tae Gun Shin
SJR Q3Signa VitaeOA

Objective. We conducted this study to evaluate the clinical outcomes of patients with severe sepsis and septic shock who were treated with ketamine for endotra-cheal intubation.Methods. A single-center, retrospective study was carried out to compare the out-comes of patients with severe sepsis and septic shock who received a ketamine or non-ketamine agent for rapid sequence intubation (RSI). We analyzed the sepsis registry for adult patients who presented to the emergency department (ED), met th

Critical Care and Intensive Care MedicineMedicine

Research Areas

Emergency MedicineEpidemiologyPulmonary and Respiratory MedicineCardiology and Cardiovascular MedicineSurgeryAnesthesiology and Pain Medicine

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