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Myeonghun Han

Hanyang University · Medicine

About the Lab

Professor Myeonghun Han's research lab focuses on cerebrovascular diseases, particularly stroke and intracranial hemorrhages, with an emphasis on understanding the impact of environmental and meteorological factors on disease incidence and recurrence. The lab investigates clinical and epidemiological patterns of subarachnoid hemorrhage, chronic subdural hematoma, and other neurological conditions, integrating statistical modeling and population-based data to identify risk factors and improve patient outcomes. Their work also explores the role of neurogenesis and neural repair mechanisms in neurological disorders, bridging clinical neurology with translational neuroscience.

cerebrovascular diseasestroke incidencemeteorological factorsintracranial hemorrhageneurological outcomes

Research Overview

Papers
91
Total Citations
1,073
Papers (5y)
28
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
28total
2022
2023
2024
2025
2026
Citations per year (5y)
145total
20222023202420252026

Selected Papers

15
1
Article|92 citations·2016
Predictive factors for recurrence and clinical outcomes in patients with chronic subdural hematoma
Myung‐Hoon Han, Je Il Ryu, Choong Hyun Kim, Jae Min Kim, Jin Hwan Cheong, Hyeong-Joong Yi
SJR Q1Journal of neurosurgeryOA

OBJECTIVE Chronic subdural hematoma (CSDH) is a common type of intracranial hemorrhage in elderly patients. Many studies have suggested various factors that may be associated with the recurrence of CSDH. However, the results are inconsistent. The purpose of this study was to determine the associations among patient factors, recurrence, and clinical outcomes of CSDH after bur hole surgery performed during an 11-year period at twin hospitals. METHODS Kaplan-Meier analysis was performed to evaluate

NeurologyMedicine
2
Article|85 citations·2015
Effect of Seasonal and Monthly Variation in Weather and Air Pollution Factors on Stroke Incidence in Seoul, Korea
Myung‐Hoon Han, Hyeong-Joong Yi, Youngsoo Kim, Young-Seo Kim
SJR Q1Stroke

BACKGROUND AND PURPOSE: The purpose of the present study was to determine whether seasonal and monthly variations in stroke incidence exist and whether they are related to meteorologic and air pollution parameters under similar weather and environmental conditions in selected areas of Seongdong district, Seoul, South Korea. METHODS: From January 1, 2004, to December 31, 2013, 3001 consecutive stroke events were registered in residents of selected areas of Seongdong district, Seoul, South Korea.

Health, Toxicology and MutagenesisEnvironmental Science
3
Article|58 citations·2016
Association between hemorrhagic stroke occurrence and meteorological factors and pollutants
Myung‐Hoon Han, Hyeong-Joong Yi, Yong Ko, Young-Soo Kim, Young‐Jun Lee
SJR Q2BMC NeurologyOA

BACKGROUND: The purpose of this study is to determine whether intracerebral hemorrhage and subarachnoid hemorrhage have different incidence patterns based on monthly variations in meteorological and air pollution parameters in the Seongdong district of Seoul, South Korea. METHODS: From January 1, 2004 to December 31, 2014, 1,477 consecutive hemorrhagic stroke events (>19 years old) were registered among residents of the Seongdong district, Seoul, South Korea. The authors calculated the relative

Health, Toxicology and MutagenesisEnvironmental Science
4
Article|29 citations·2017
Monthly variations in aneurysmal subarachnoid hemorrhage incidence and mortality: Correlation with weather and pollution
Myung‐Hoon Han, Jinhee Kim, Kyu-Sun Choi, Choong Hyun Kim, Jae Min Kim, Jin Hwan Cheong, Hyeong-Joong Yi, Seon Heui Lee
SJR Q1PLoS ONEOA

We showed distinct patterns of seasonal and monthly variation in the occurrence and mortality of SAH. Our findings suggest that meteorological factors may play an important role in monthly variations in the occurrence of aneurysmal SAH.

Health, Toxicology and MutagenesisEnvironmental Science
5
Review|28 citations·2016
Current Opinion on the Role of Neurogenesis in the Therapeutic Strategies for Alzheimer Disease, Parkinson Disease, and Ischemic Stroke; Considering Neuronal Voiding Function
Myung‐Hoon Han, Eun Hye Lee, Seong‐Ho Koh
SJR Q2International Neurourology JournalOA

Neurological diseases such as Alzheimer, Parkinson, and ischemic stroke have increased in occurrence and become important health issues throughout the world. There is currently no effective therapeutic strategy for addressing neurological deficits after the development of these major neurological disorders. In recent years, it has become accepted that adult neural stem cells located in the subventricular and subgranular zones have the ability to proliferate and differentiate in order to replace

Developmental NeuroscienceNeuroscience
6
Article|25 citations·2021
Association between tumor size and peritumoral brain edema in patients with convexity and parasagittal meningiomas
Chansub Shin, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Yu Deok Won, Yong Ko, Myung‐Hoon Han
SJR Q1PLoS ONEOA

BACKGROUND AND PURPOSE: Peritumoral brain edema (PTBE) is a common complication in meningioma and disruption of the tumor-brain barrier in meningioma is crucial for PTBE formation. To evaluate the association between meningioma size and PTBE, we measured meningioma volumes using the 3D slicer in patients with convexity and parasagittal meningiomas. METHODS: Receiver operating characteristic curve analysis was used to determine the optimal cut-off meningioma volume values for predicting PTBE occu

EpidemiologyMedicine
7
Article|24 citations·2016
Increased Short-Term Mortality in Patients with Spontaneous Intracerebral Hemorrhage and its Association with Admission Glucose Levels and Leukocytosis
Young-Jin Kim, Myung‐Hoon Han, Choong-Hyun Kim, Jae-Min Kim, Jin Hwan Cheong, Je-Il Ryu
SJR Q2World Neurosurgery
NeurologyMedicine
8
Article|23 citations·2018
Opportunistic osteoporosis screening via the measurement of frontal skull Hounsfield units derived from brain computed tomography images
Min Kyun Na, Yu Deok Won, Choong Hyun Kim, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Myung‐Hoon Han
SJR Q1PLoS ONEOA

Clinical brain CT scans can assist in the detection of osteoporosis, and patients with an HU value < 610 as determined via brain CT may be considered for further evaluation for possible osteoporosis.

Orthopedics and Sports MedicineMedicine
9
Article|21 citations·2016
Current Opinion on the Role of Neurogenesis in the Therapeutic Strategies for Alzheimer Disease, Parkinson Disease, and Ischemic Stroke; Considering Neuronal Voiding Function
한명훈, 이은혜, 고성호

Neurological diseases such as Alzheimer, Parkinson, and ischemic stroke have increased in occurrence and become important health issues throughout the world. There is currently no effective therapeutic strategy for addressing neurological deficits after the development of these major neurological disorders. In recent years, it has become accepted that adult neural stem cells located in the subventricular and subgranular zones have the ability to proliferate and differentiate in order to replace

10
Article|20 citations·2022
High DKK3 expression related to immunosuppression was associated with poor prognosis in glioblastoma: machine learning approach
Myung‐Hoon Han, Kyueng‐Whan Min, Yung‐Kyun Noh, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Yu Deok Won, Seong‐Ho Koh, Jae Kyung Myung, Ji Young Park, Mi Jung Kwon
SJR Q1Cancer Immunology ImmunotherapyOA

BACKGROUND: Glioblastoma multiforme (GBM) is an aggressive malignant primary brain tumor. Wnt/β-catenin is known to be related to GBM stemness. Cancer stem cells induce immunosuppressive and treatment resistance in GBM. We hypothesized that Wnt/β-catenin-related genes with immunosuppression could be related to the prognosis in patients with GBM. METHODS: We obtained the clinicopathological data of 525 patients with GBM from the brain cancer gene database. The fraction of tumor-infiltrating immun

Molecular BiologyBiochemistry, Genetics and Molecular Biology
11
Article|19 citations·2018
Association Between Possible Osteoporosis and Shunt-Dependent Hydrocephalus After Subarachnoid Hemorrhage
Myung‐Hoon Han, Yu Deok Won, Min Kyun Na, Choong Hyun Kim, Jae Min Kim, Je Il Ryu, Hyeong-Joong Yi, Jin Hwan Cheong
SJR Q1Stroke

Background and Purpose- Pathological obstruction in arachnoid granulations after subarachnoid hemorrhage (SAH) can impede cerebrospinal fluid flow outward to the venous sinus and causing hydrocephalus. Because bone and arachnoid granulations share the same collagen type, we evaluated the possible relation between bone mineral density and shunt-dependent hydrocephalus after SAH. Methods- We measured Hounsfield units of the frontal skull on admission brain computed tomography in patients with SAH.

NeurologyMedicine
12
Article|18 citations·2016
Factors That Predict Risk of Cervical Instability in Rheumatoid Arthritis Patients
Myung‐Hoon Han, Je Il Ryu, Choong Hyun Kim, Jae Min Kim, Jin Hwan Cheong, Koang Hum Bak, Hyoung-Joon Chun, Hyeong-Joong Yi, Jae Bum Jun, Jaewoo Chung
SJR Q1Spine

STUDY DESIGN: Retrospective data analysis. OBJECTIVE: To identify factors affecting the atlantodental interval, the Ranawat value, and subaxial translation after rheumatoid arthritis (RA) diagnosis. In addition, factors predictive for cervical spine instability (CSI) development after RA diagnosis were examined. SUMMARY OF BACKGROUND DATA: Development of CSI affects the prognosis and mortality of RA patients. Previous studies described that obesity is associated with reduced radiographic joint d

SurgeryMedicine
13
Article|17 citations·2018
The frontal skull Hounsfield unit value can predict ventricular enlargement in patients with subarachnoid haemorrhage
Yu Deok Won, Min Kyun Na, Choong Hyun Kim, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Myung‐Hoon Han
SJR Q1Scientific ReportsOA

Hydrocephalus is a common complication following subarachnoid haemorrhage (SAH) arising from spontaneous aneurysm rupture. The Hounsfield unit (HU) value from computed tomography scans may reflect bone mineral density, which correlates with body mass index, which in turn is related to post-SAH ventricle size changes. We herein investigated potential associations between frontal skull HU values and ventricle size changes after SAH. HU values from four different areas in the frontal bone were aver

NeurologyMedicine
14
Article|15 citations·2016
Association between Diurnal Variation of Ozone Concentration and Stroke Occurrence: 24-Hour Time Series Study
Myung‐Hoon Han, Hyeong-Joong Yi, Young-Seo Kim, Yong Ko, Youngsoo Kim
SJR Q1PLoS ONEOA

The results show diurnal patterns of ischemic stroke occurrence based on upper and lower median ozone levels for a 24-hour period, which extends understanding of the association between stroke occurrence and environmental influences.

Health, Toxicology and MutagenesisEnvironmental Science
15
Article|13 citations·2017
Early variations of laboratory parameters predicting shunt-dependent hydrocephalus after subarachnoid hemorrhage
Min Kyun Na, Yu Deok Won, Choong Hyun Kim, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Myung‐Hoon Han
SJR Q1PLoS ONEOA

Despite the exploratory nature of this study, we found that higher sodium, lower potassium, and higher glucose levels were predictive values for shunt-dependent hydrocephalus from postoperative day (POD) 1 to POD 12-16 after subarachnoid hemorrhage. Strict correction of electrolyte imbalance seems necessary to reduce shunt-dependent hydrocephalus. Further large studies are warranted to confirm our findings.

Cellular and Molecular NeuroscienceNeuroscience

Research Areas

NeurologySurgeryEpidemiologyPhysiologyMolecular BiologyGenetics

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