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Rena Lee

Ewha Womans University · Physics and Astronomy

About the Lab

Professor Rena Lee's research lab specializes in advanced medical imaging and radiation therapy optimization, focusing on improving image-guided radiotherapy, respiratory motion management, and image reconstruction techniques. The lab investigates innovative image fusion methods—such as CT-3D ultrasound and CT-MR fusion—for accurate target localization and treatment planning. It also explores radiation-free patient setup technologies, including 3D optical surface imaging, and develops advanced reconstruction algorithms using tensor framelet regularization for low-dose CT imaging. The lab integrates statistical process control and quality assurance frameworks to enhance treatment delivery accuracy and safety across various cancer sites.

image-guided radiotherapy3D optical surface imagingiterative CT reconstructionrespiratory motion managementimage fusion

Research Overview

Papers
173
Total Citations
1,616
Papers (5y)
19
Primary Field
Physics and Astronomy

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
19total
2021
2022
2023
2024
2025
Citations per year (5y)
37total
20212022202320242025

Selected Papers

15
1
Article|33 citations·2018
Surgery vs. radiotherapy for locally advanced hypopharyngeal cancer in the contemporary era: A population‐based study
Yi‐Jun Kim, Rena Lee
SJR Q1Cancer MedicineOA

OBJECTIVES: To compare overall survival (OS) in locally advanced hypopharyngeal cancer treated with surgery or definitive chemoradiotherapy in the contemporary era. METHODS: From 2010 to 2015, data for patients diagnosed with hypopharyngeal cancer (T2-T4aM0) and treated with total pharyngectomy with lymph node dissection (surgery group) or definitive radiotherapy and chemotherapy (chemoradiotherapy group) was retrieved from the SEER database. Multivariate analyses were performed in each subgroup

OtorhinolaryngologyMedicine
2
Article|19 citations·2014
Accuracy of surface registration compared to conventional volumetric registration in patient positioning for head‐and‐neck radiotherapy: A simulation study using patient data
Youngjun Kim, Ruijiang Li, Yong Hum Na, Rena Lee, Lei Xing
SJR Q1Medical PhysicsOA

PURPOSE: 3D optical surface imaging has been applied to patient positioning in radiation therapy (RT). The optical patient positioning system is advantageous over conventional method using cone-beam computed tomography (CBCT) in that it is radiation free, frameless, and is capable of real-time monitoring. While the conventional radiographic method uses volumetric registration, the optical system uses surface matching for patient alignment. The relative accuracy of these two methods has not yet b

RadiationPhysics and Astronomy
3
Article|10 citations·2013
Accuracy of volume measurement using 3D ultrasound and development of CT-3D US image fusion algorithm for prostate cancer radiotherapy
Jihye Baek, Jangyoung Huh, Myungsoo Kim, So Hyun An, Yoonjin Oh, Dongyoung Kim, K. Chung, Sungho Cho, Rena Lee
SJR Q1Medical Physics

3D US could be used in the volume measurement of human bladders and prostates. CT-3D US image fusion could be used in monitoring the target position in each fraction of external beam radiation therapy. Moreover, the feasibility of replacing the CT-MR image fusion to the CT-3D US in radiotherapy treatment planning was verified.

RadiationPhysics and Astronomy
4
Article|10 citations·2014
Motion management within two respiratory-gating windows: feasibility study of dual quasi-breath-hold technique in gated medical procedures
Taeho Kim, Siyong Kim, Yang-Kyun Park, Kaylin K Youn, Paul Keall, Rena Lee
SJR Q1Physics in Medicine and Biology

A dual quasi-breath-hold (DQBH) technique is proposed for respiratory motion management (a hybrid technique combining breathing-guidance with breath-hold task in the middle). The aim of this study is to test a hypothesis that the DQBH biofeedback system improves both the capability of motion management and delivery efficiency. Fifteen healthy human subjects were recruited for two respiratory motion measurements (free breathing and DQBH biofeedback breathing for 15 min). In this study, the DQBH b

RadiationPhysics and Astronomy
5
Article|4 citations·2003
유럽, 미국, 일본의 선형가속기 정도관리 비교
이레나, 이수진, 최진호
6
Article|3 citations·2017
Statistical Process Control Analysis for Patient Quality Assurance of Intensity Modulated Radiation Therapy
이레나, 김규보, 조삼주, 임상욱, 이석, 심장보, 허현도, 이상훈, 안소현

This study applied statistical process control to set and verify the quality assurances (QA) tolerance standard for our hospital’s characteristics with the criteria standards that are applied to all the treatment sites with this analysis. Gamma test factor of delivery quality assurances (DQA) was based on 3%/3 mm. Head and neck, breast, prostate cases of intensity modulated radiation therapy (IMRT) or volumetric arc radiation therapy (VMAT) were selected for the analysis of the QA treatment site

7
Article|3 citations·2017
Statistical process control analysis for patient quality assurance of intensity modulated radiation therapy
Rena Lee, Kyubo Kim, Samju Cho, Sangwook Lim, Suk Lee, Jang Bo Shim, Hyun Do Huh, Suk Lee, Sohyun Ahn
SJR Q3Journal of the Korean Physical Society

This study applied statistical process control to set and verify the quality assurances (QA) tolerance standard for our hospital’s characteristics with the criteria standards that are applied to all the treatment sites with this analysis. Gamma test factor of delivery quality assurances (DQA) was based on 3%/3 mm. Head and neck, breast, prostate cases of intensity modulated radiation therapy (IMRT) or volumetric arc radiation therapy (VMAT) were selected for the analysis of the QA treatment site

RadiationPhysics and Astronomy
8
Article|3 citations·2019
Tensor framelet based iterative image reconstruction algorithm for low-dose multislice helical CT
Haewon Nam, Minghao Guo, Hengyong Yu, Keumsil Lee, Ruijiang Li, Bin Han, Lei Xing, Rena Lee, Hao Gao
SJR Q1PLoS ONEOA

In this study, we investigate the feasibility of improving the imaging quality for low-dose multislice helical computed tomography (CT) via iterative reconstruction with tensor framelet (TF) regularization. TF based algorithm is a high-order generalization of isotropic total variation regularization. It is implemented on a GPU platform for a fast parallel algorithm of X-ray forward band backward projections, with the flying focal spot into account. The solution algorithm for image reconstruction

Radiology, Nuclear Medicine and ImagingMedicine
9
Book Chapter|2 citations·2021
The Journey to Realisation
Rena Lee
OA
Management Science and Operations ResearchDecision Sciences
10
Article|1 citations·2010
Surgical Clips for Observation of Respiratory Motion of Breast via 2D Fluoroscopy and 3D CT scan
Rena Lee, Hyunsuk Suh
SJR Q3Journal of the Korean Physical Society
Pulmonary and Respiratory MedicineMedicine
11
Article|1 citations·2006
Analysis of the Movement of Surgical Clips Implanted in Tumor Bed during Normal Breathing for Breast Cancer Patients
Rena Lee, Eunah Chung, 서현숙, Kyungjalee, 이지혜
SJR Q2Radiation Oncology Journal
Complementary and alternative medicineMedicine
12
Book Chapter|1 citations·2017
Exploration and Exploitation of Ocean Mineral Resources: The Role of Sponsoring States
Rena Lee

In 2011, the Seabed Disputes Chamber of the International Tribunal for the Law of the Sea set out its opinion of the responsibilities and obligations of sponsoring states. In particular, it examined both the “due diligence” as well as the “direct” obligations of the sponsoring states. These obligations demonstrate the role played by the sponsoring states, which the Advisory Opinion has referred to as the “common-interest” role. One aspect of the common-interest role, which involves the implement

Management, Monitoring, Policy and LawEnvironmental Science
13
Article|1 citations·2008
Bladder Volume Variations in Patients Receiving Conformal Radiotherapy to Prostate
Rena Lee, 이지혜, Kyungjalee, 지영훈
SJR Q3Journal of Radiation Protection and Research
Pulmonary and Respiratory MedicineMedicine
14
Article|1 citations·2010
Surgical Clips for Observation of Respiratory Motion of the Breast Via 2D Fluoroscopy and 3D CT Scans
이레나, 서현숙

Many breathing techniques have been applied for an accurate treatment of the breast. A normal breathing technique that could provide an equally accurate treatment with less intervention and shorter treatment time is worth investigating by thoroughly observing the respiratory motion of the breast via 2D fluoroscopy and 3D CT scans with surgical clips for position verification of the tumor bed. A group of 22 patients with surgical clips implanted in the lumpectomy cavity during breast-conserving s

15
Article|1 citations·2008
전립선암 환자의 방사선 치료 시 방광 체적 변화
이레나, 이지혜, 이경자, 지영훈

목 적: 전립선암 환자의 방사선 치료 시 전립선의 위치 변화 및 비뇨기계 부작용을 줄이기 위해 방광의 체적을 일정하게 유지하도록 한 후 초음파를 이용하여 방광의 체적 변화를 측정 하였다. 대상 및 방법: 2002년 12월부터 2007년 8월 까지 이대 목동병원에서 전립선 암으로 진단받고 근치적 목적의 방사선 치료를 받은 환자 26명을 대상으로 하였다. 13명의 실험군 환자는 방광의 체적을 일정하게 유지하기 위하여 모의조사, CT 스캔, 및 치료 1시간 전에 450 cc의 물을 마시도록 하였다. 나머지 13 명의 대조군 환자에 대해서는 특별한 지시를 하지 않았다. 각 환자의 CT 영상에서 방광의 체적을 측정하였다. 3차원 입체 조형 치료 계획이 설계되었고 처방선량 70.2 Gy 조사할 경우 방광과 직장의 유효체적을 계산 하였다. 실험군에 속해 있는 환자에 대해 방사선 치료 전 방광의 체적을 초음파를 이용하여 6-8주 간 매주 측정하였고 방광의 체적 변화를 분석하였다. 결과: CT

Research Areas

RadiationStrategy and ManagementBiomedical EngineeringAerospace EngineeringPulmonary and Respiratory MedicineRadiology, Nuclear Medicine and Imaging

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