Skip to main content

Ryu Jae-joon

Korea University · Dentistry

About the Lab

Professor Ryu Jae-joon's research lab specializes in biomaterials and tissue engineering for oral and maxillofacial applications, with a strong focus on enhancing osseointegration and bone regeneration. The lab investigates advanced implant materials, including RGD-functionalized titanium surfaces and nitric oxide-releasing scaffolds, to improve osteogenic and angiogenic responses. Key research directions include the development of bioactive materials for guided bone regeneration, optimization of dental cement polymerization under clinical conditions, and the role of systemic diseases in temporomandibular joint disorders. The lab integrates in vitro biological evaluation with translational approaches to bridge materials innovation and clinical outcomes in dentistry.

bone regenerationnitric oxide releasedental implantsscaffold materialsosseointegration

Research Overview

Papers
157
Total Citations
3,043
Papers (5y)
23
Primary Field
Dentistry

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
23total
2022
2023
2024
2025
2026
Citations per year (5y)
75total
20222023202420252026

Selected Papers

15
1
Article|402 citations·2019
Printing accuracy, mechanical properties, surface characteristics, and microbial adhesion of 3D-printed resins with various printing orientations
Ji Suk Shim, Jong‐Eun Kim, Sang Hoon Jeong, Yeon‐Jo Choi, Jae‐Jun Ryu
SJR Q1Journal of Prosthetic Dentistry
Automotive EngineeringEngineering
2
Review|36 citations·2017
Types of devices used in ridge split procedure for alveolar bone expansion: A systematic review
Nayansi Jha, Eun Ha Choi, Nagendra Kumar Kaushik, Jae‐Jun Ryu
SJR Q1PLoS ONEOA

The aim of this systematic review was to evaluate instrumentation procedures of the alveolar ridge expansion technique (ARST) with or without Guided Bone Regeneration (GBR) and to identify the most used instruments for successful outcome. An electronic as well as manual literature search was conducted in several databases including Medline, Embase, and Cochrane Central Register of Controlled Trials, for articles written in English up to September 2016. The question in focus was to identify the t

Oral SurgeryDentistry
3
Article|31 citations·2013
Effects of Anodized Titanium with Arg-Gly-Asp (RGD) Peptide Immobilized Via Chemical Grafting or Physical Adsorption on Bone Cell Adhesion and Differentiation
Jae‐Jun Ryu, Kyeongsoon Park, Hyo-Sop Kim, Chang-Mo Jeong, Jung‐Bo Huh
SJR Q2The International Journal of Oral & Maxillofacial Implants

RGD-immobilized Ti substrates might be effective in improving the osseointegration of dental implants. In particular, the chemical grafting method of RGD immobilization is more favorable and is expected to provide positive outcomes with future animal and clinical studies.

Biomedical EngineeringEngineering
4
Article|29 citations·2017
Polymerization Mode of Self‐Adhesive, Dual‐Cured Dental Resin Cements Light Cured Through Various Restorative Materials
Ji Suk Shim, Jeong Kyung Kang, Nayansi Jha, Jae‐Jun Ryu
SJR Q1Journal of Esthetic and Restorative Dentistry

ABSTRACT Objective The aim of this study was to investigate the polymerization mode of self‐adhesive, dual‐cured resin cements light‐cured through overlying materials with different degree of translucency by measuring the degree of conversion (DC). Materials and Methods Three kinds of self‐adhesive, dual‐cured resin cements (G‐CEM LinkAce TM , Maxcem Elite TM , and BisCem ® ) were light‐cured through three different restorative materials that included porcelain‐fused metal (PFM), zirconia, and l

OrthodonticsDentistry
5
Article|29 citations·2022
Guided Bone Regeneration with a Nitric‐Oxide Releasing Polymer Inducing Angiogenesis and Osteogenesis in Critical‐Sized Bone Defects
Jong‐Eun Won, Won Jong Kim, Ji Suk Shim, Jae‐Jun Ryu
SJR Q1Macromolecular Bioscience

Synthetic scaffolds, as bone grafts, provide a favorable environment for the repair and growth of new bone tissue at defect sites. However, the lack of angio- and osteo-induction limits the usefulness of artificial scaffolds for bone regeneration. Nitric oxide (NO) performs essential roles in healing processes, such as regulating inflammation and addressing incomplete revascularization. In this study, a polymer capable of controlled NO release is developed to promote the osteogenic capacity in a

Biomedical EngineeringEngineering
6
Article|23 citations·2020
Correlation between TM joint disease and rheumatic diseases detected on bone scintigraphy and clinical factors
Ji Suk Shim, Chulhan Kim, Jae‐Jun Ryu, Sung Jae Choi
SJR Q1Scientific ReportsOA

The aim of this study was to evaluate the effect of rheumatic disease as a risk factor for temporomandibular disease (TMD). A total of 143 outpatients reporting symptoms indicating rheumatic disease at their first visit to the rheumatology clinic were included. We evaluated the temporomandibular joint (TMJ) with scintigraphic images, and standard questionnaires were administered for the symptomatic assessment for all patients. The patients were classified into 'healthy controls' or as per their

Complementary and Manual TherapyHealth Professions
7
Article|18 citations·2018
The influence of bone graft procedures on primary stability and bone change of implants placed in fresh extraction sockets
Sang-Ho Jun, Chang‐Joo Park, Suk-Hyun Hwang, Youn Ki Lee, Cong Zhou, Hyon-Seok Jang, Jae‐Jun Ryu
SJR Q2Maxillofacial Plastic and Reconstructive SurgeryOA

This study was to evaluate the effect of bone graft procedure on the primary stability of implants installed in fresh sockets and assess the vertical alteration of peri-implant bone radiographically. Twenty-three implants were inserted in 18 patients immediately after tooth extraction. The horizontal gap between the implant and bony walls of the extraction socket was grafted with xenografts. The implant stability before and after graft procedure was measured by Osstell Mentor as implant stabilit

Oral SurgeryDentistry
8
Article|18 citations·2018
Antimicrobial activity of NO-releasing compounds against periodontal pathogens
Ji Suk Shim, Dong-Sik Park, Dong-Heon Baek, Nayansi Jha, Serk In Park, Hyoung Jin Yun, Won Jong Kim, Jae‐Jun Ryu
SJR Q1PLoS ONEOA

This study describes the successful synthesis of nitric oxide (NO)-releasing compounds with biodegradable and injectable properties and demonstrates that the kinetics of NO release vary according to the type of NO donor. The antimicrobial activity of NO-releasing compounds against three common periodontal pathogens, i.e., Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Actinomyces israelii, was investigated using a susceptibility assay. Human gingival fibroblasts were treate

PhysiologyMedicine
9
Article|17 citations·2021
Modulation of Lithium Disilicate Translucency through Heat Treatment
Seok‐Ki Jung, Dae Woon Kim, Jeong‐Yol Lee, Selvaponpriya Ramasamy, Hyun‐Sik Kim, Jae‐Jun Ryu, Ji Suk Shim
SJR Q2MaterialsOA

The aim of this study was to present a control method for modulating the translucency of lithium disilicate ceramics through thermal refinement. Identical lithium disilicate blocks were thermally refined using four different heat treatment schedules, and the microstructure, translucency, and flexural strength of the ceramics were investigated in detail by SEM, spectroscopy, and a piston-on-three-ball test. The results showed that ceramics treated under higher heat had larger grains, with an aver

Materials ChemistryMaterials Science
10
Article|13 citations·2016
Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration
Jin-Chul Park, Eun‐Bin Bae, Se-Eun Kim, So-Yun Kim, Kyung Hee Choi, Jae-Won Choi, Ji-Hyeon Bae, Jae‐Jun Ryu, Jung‐Bo Huh
SJR Q2MaterialsOA

This study was undertaken to investigate the effect of loading rhBMP-2 onto biphasic calcium phosphate (BCP) and calcium pyrophosphate (CPP) on bone regeneration, and to examine the efficacies of BCP and CPP as rhBMP-2 carriers. Specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups; BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP were prepared as discs, which were treated with rhBMP-2 and collagen. Physical and biological features were investigated u

Biomedical EngineeringEngineering
11
Article|13 citations·2008
Effects of tobacco compounds on gene expression in fetal lung fibroblasts
Sung‐Hwa Sohn, Ki‐Nam Kim, In Kyoung Kim, Eunil Lee, Jae‐Jun Ryu, Meyoung‐Kon Kim
SJR Q2Environmental Toxicology

The goal of this study was to determine the effects of tobacco compounds on gene expression in a human fetal lung cell line (WI38). In the present study, we investigated the effects of tobacco compounds (nicotine, benzo(a)pyrene (B(a)P), and 2-Naphthylamine) on gene expression profiles in human fetal fibroblasts using cDNA microarray and real-time PCR. WI38 cells were cultured in Eagle's minimum essential medium (MEM) supplemented with 10% fetal bovine serum, 2% 200 mM L-glutamine, and a 2% peni

Molecular BiologyBiochemistry, Genetics and Molecular Biology
12
Article|11 citations·2021
Multi-functional effects of a nitric oxide-conjugated copolymer for accelerating palatal wound healing
Jong‐Eun Won, Jung Hyun Shin, Jinseong Kim, Won Jong Kim, Jae‐Jun Ryu, Ji Suk Shim
Materials Science and Engineering C
PhysiologyMedicine
13
Article|11 citations·2022
Bioactive Nonthermal Biocompatible Plasma Enhances Migration on Human Gingival Fibroblasts
Ihn Han, In‐Seok Song, Seung Ah Choi, Tae Bok Lee, Maksudbek Yusupov, Priyanka Shaw, Annemie Bogaerts, Eun Ha Choi, Jae‐Jun Ryu
SJR Q1Advanced Healthcare Materials

This study hypothesizes that the application of low-dose nonthermal biocompatible dielectric barrier discharge plasma (DBD-NBP) to human gingival fibroblasts (HGFs) will inhibit colony formation but not cell death and induce matrix metalloproteinase (MMP) expression, extracellular matrix (ECM) degradation, and subsequent cell migration, which can result in enhanced wound healing. HGFs treated with plasma for 3 min migrate to each other across the gap faster than those in the control and 5-min tr

BiomaterialsMaterials Science
14
Article|9 citations·2013
Proteomic analysis of the biological response of MG63 osteoblast-like cells to titanium implants
Chang Su Kim, Kee‐Joon Lee, Jung‐Eun Kim, Yun-Gyu Park, Jae‐Jun Ryu, Hang‐Rae Kim
SJR Q2OdontologyOA
Biomedical EngineeringEngineering
15
Article|7 citations·2019
Polymerization efficiency of dental dual-cured resin cement light-cured at various times after the initiation of chemical activation
Ji Suk Shim, Soo Young Lee, So-Yeon Song, Nayansi Jha, Jae‐Jun Ryu
SJR Q2International Journal of Polymeric Materials

This study reports the effect of light-exposure timing on the polymerization results of the dental dual-cured resin cement using multiple measurements over time. Specimens were light-polymerized at 5 different delayed time points after mixing the materials: immediate (1 min), 10 min, 30 min, 60 min, and 2 weeks. The degree of conversion (DC) measurement with infrared spectroscopy (IR) measurements and surface hardness test with Vickers diamond indenter was performed. The group that underwent imm

OrthodonticsDentistry

Research Areas

OrthodonticsOral SurgeryBiomedical EngineeringPhysiologyPeriodonticsComplementary and Manual Therapy

Dive deeper into Ryu Jae-joon's research on Nubint

Open this lab's papers in the app to read with AI, summarize, and cite in your writing.