Se Chang Park
Seoul National University · Environmental Science
About the Lab
Professor Se Chang Park's research lab focuses on developing alternative biocontrol strategies for aquatic animal pathogens, particularly targeting antibiotic-resistant bacteria such as *Pseudomonas plecoglossicida*, *Vibrio parahaemolyticus*, and *Vibrio alginolyticus*. The lab specializes in the isolation, characterization, and application of bacteriophages as therapeutic agents in aquaculture, with an emphasis on phage therapy and biocontrol. Additionally, the lab investigates probiotic bacteria, such as *Lactobacillus reuteri* and *L. plantarum*, for their protective effects against environmental stressors like heavy metal toxicity and for enhancing fermentation processes. The overarching research direction centers on sustainable and eco-friendly solutions for disease management in aquaculture and environmental health.
Research Overview
Research Output Trend
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Selected Papers
15Two types of bacteriophage specific to Pseudomonas plecoglossicida, the causative agent of bacterial hemorrhagic ascites disease in cultured ayu fish (Plecoglossus altivelis), were isolated from diseased ayu and the rearing pond water. One type of phage, which formed small plaques, was tentatively classified as a member of the family Myoviridae, and the other type, which formed large plaques, was classified as a member of the family Podoviridae. All 27 strains of P. plecoglossicida examined, whi
Two previously isolated phages were used to examine the therapeutic effects against Pseudomonas plecoglossicida infection in ayu Plecoglossus altivelis. Phage PPp-W4 (Podoviridae) inhibited the in vitro growth of P. plecoglossicida more effectively than Phage PPpW-3 (Myoviridae), and a mixture (PPpW-3/W-4) of the 2 phages exhibited the highest inhibitory activity. In phage therapy experiments, ayu were fed P. plecoglossicida-impregnated feed (10(7) CFU fish(-1)) and then fed phage-impregnated fe
BACKGROUND: Recently isolated Vibrio parahaemolyticus strains have displayed multiple antibiotic resistance. Alternatives to conventional antibiotics are needed, especially for the multiple-antibiotic-resistant V. parahaemolyticus pandemic strain. METHODS: A bacteriophage, designated pVp-1, showed effective infectivity for multiple-antibiotic-resistant V. parahaemolyticus and V. vulnificus, including V. parahaemolyticus pandemic strains. The therapeutic potential of the phage was studied in a mo
There is an increasing emergence of antibiotic-resistant Vibrio alginolyticus, a zoonotic pathogen that causes mass mortality in aquatic animals and infects humans; therefore, there is a demand for alternatives to antibiotics for the treatment and prevention of infections caused by this pathogen. One possibility is through the exploitation of bacteriophages. In the present study, the novel bacteriophage pVa-21 was classified as Myoviridae and characterised as a candidate biocontrol agent against
Harmful effects of heavy metals are myriad. Lead (Pb) from soil and atmosphere contaminates water bodies and affects the aquatic animals. Our previous study confirmed the <i>in vitro</i> probiotic potential of <i>Lactobacillus reuteri</i> against Pb toxicity, but further investigation is necessary for gaining insights into the related protection mode. Therefore, in this study, we investigated the protective effects of the potential probiotic <i>L. reuteri</i> P16 against waterborne Pb exposure-i
This study aimed to isolate potential probiotic lactic acid bacteria from a traditional rice-based fermented beverage "bhaati jaanr" and to evaluate their role during preparation of the beverage. Among various isolates, <i>Lactobacillus plantarum</i> strain L7 exhibited satisfactory <i>in vitro</i> probiotic characteristics such as acid resistance and bile tolerance, cell surface hydrophobicity, auto-aggregation, antibiotic susceptibility, and antimicrobial activities. Therefore, performance of
Research Areas
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