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Seung Beom Han

Korea University · Medicine

About the Lab

Professor Seung Beom Han's research lab specializes in orthopedic biomechanics and regenerative medicine, with a primary focus on knee osteoarthritis and lower limb alignment correction. The lab investigates surgical interventions such as high tibial osteotomy (HTO) and unicompartmental knee arthroplasty (UKA), emphasizing alignment accuracy, soft tissue laxity, and long-term outcomes. It also explores regenerative therapies, including hyaluronic acid, platelet-rich plasma, and mesenchymal stem cell injections, for osteoarthritis treatment. Additionally, the lab examines metabolic and developmental impacts of environmental toxins, such as lead, on maternal and fetal health.

knee osteoarthritishigh tibial osteotomyregenerative therapylower limb alignmentpostoperative complications

Research Overview

Papers
141
Total Citations
2,029
Papers (5y)
37
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
37total
2021
2022
2023
2024
2025
Citations per year (5y)
292total
20212022202320242025

Selected Papers

15
1
Article|158 citations·2015
Effect of soft tissue laxity of the knee joint on limb alignment correction in open-wedge high tibial osteotomy
Dae‐Hee Lee, Sung‐Chul Park, Hyung-Joon Park, Seung-Beom Han
SJR Q1Knee Surgery Sports Traumatology Arthroscopy

PURPOSE: Open-wedge high tibial osteotomy (HTO) cannot always accurately correct limb alignment, resulting in under- or over-correction. This study assessed the relationship between soft tissue laxity of the knee joint and alignment correction in open-wedge HTO. METHODS: This prospective study involved 85 patients (86 knees) undergoing open-wedge HTO for primary medial osteoarthritis. The mechanical axis (MA), weight-bearing line (WBL) ratio, and joint line convergence angle (JLCA) were measured

SurgeryMedicine
2
Review|84 citations·2020
Intra‐Articular Injections of Hyaluronic Acid or Steroids Associated With Better Outcomes Than Platelet‐Rich Plasma, Adipose Mesenchymal Stromal Cells, or Placebo in Knee Osteoarthritis: A Network Meta‐analysis
Seung-Beom Han, In-Wook Seo, Young-Soo Shin
SJR Q1Arthroscopy The Journal of Arthroscopic and Related Surgery

PURPOSE: To evaluate the clinical effects of hyaluronic acid (HA), steroids, platelet-rich plasma (PRP), or adipose mesenchymal stromal cell (MSC) injections in the treatment of knee osteoarthritis (OA). METHODS: Randomized controlled trials with OA of the knee that compared HA, steroids, PRP, adipose MSC, or their combination with placebo or in head-to-head combination were identified from the MEDLINE, EMBASE, Cochrane Library, Web of Science, and SCOPUS databases up to June 30, 2019. We perfor

UrologyMedicine
3
Article|58 citations·2011
Synovial fluid CD34− CD44+ CD90+ mesenchymal stem cell levels are associated with the severity of primary knee osteoarthritis
D. H. Lee, Chung Hee Sonn, Seung-Beom Han, Yu‐Kyoung Oh, Kyung‐Mi Lee, S.-H. Lee
SJR Q1Osteoarthritis and CartilageOA
GeneticsMedicine
4
Article|56 citations·2000
Effects of lead exposure before pregnancy and dietary calcium during pregnancy on fetal development and lead accumulation.
Seung-Beom Han, David H. Pfizenmaier, Enid J García-Rivera, Maria L. Eguez, Mathew Ling, Francis W. Kemp, John D. Bogden
SJR Q1Environmental Health PerspectivesOA

Millions of women of child-bearing age have substantial bone lead stores due to lead exposure as children. Dietary calcium ingested simultaneously with lead exposure can reduce lead absorption and accumulation. However, the effects of dietary calcium on previously accumulated maternal lead stores and transfer to the fetus have not been investigated. We studied the effects of lead exposure of female rats at an early age on fetal development during a subsequent pregnancy. We gave 5-week-old female

Health, Toxicology and MutagenesisEnvironmental Science
5
Article|54 citations·2018
Early postoperative hypoalbuminemia is a risk factor for postoperative acute kidney injury following hip fracture surgery
Kyun-Ho Shin, Seung-Beom Han
SJR Q1Injury
NephrologyMedicine
6
Review|54 citations·2017
Better clinical outcomes after unicompartmental knee arthroplasty when comparing with high tibial osteotomy
Seung-Beom Han, Hee-Soo Kyung, In-Wook Seo, Young-Soo Shin
SJR Q3MedicineOA

There were no significant differences in the revision rate to TKA between HTO and UKA. However, results from subgroup analyses suggested that opening-wedge HTO resulted in a lower revision rate to TKA than did UKA, whereas closing-wedge HTO resulted in a higher revision rate to TKA than did UKA. In addition, UKA resulted in significantly better functional outcomes and postoperative velocity, along with less postoperative pain, fewer postoperative complications, and lower postoperative ROM. Based

SurgeryMedicine
7
Article|50 citations·2012
Preoperative and Postoperative Comparisons of Navigation and Radiologic Limb Alignment Measurements After High Tibial Osteotomy
Dae‐Hee Lee, Kyung-Wook Nha, Sung Jun Park, Seung-Beom Han
SJR Q1Arthroscopy The Journal of Arthroscopic and Related Surgery

PURPOSE: To determine whether navigation-assisted intraoperative lower limb alignment in open wedge high tibial osteotomy (HTO) correlates with preoperative and postoperative radiographic alignment. METHODS: This prospective study involved 35 patients (39 knees) who underwent navigation HTO for primary medial osteoarthritis. The mechanical axis (MA) and weight-bearing line (WBL) ratio were calculated from preoperative radiographs, intraoperative navigation, and postoperative (6 months) radiograp

SurgeryMedicine
9
Article|44 citations·2020
<p>Early Postoperative Hypoalbuminaemia as a Risk Factor for Postoperative Pneumonia Following Hip Fracture Surgery</p>
Kyun-Ho Shin, Jae‐Joong Kim, Sei Wook Son, Kyosun Hwang, Seung-Beom Han
SJR Q1Clinical Interventions in AgingOA

This study demonstrated that early postoperative hypoalbuminaemia is an independent risk factor for the development of postoperative pneumonia in patients undergoing hip fracture surgery.

SurgeryMedicine
10
Article|39 citations·2020
Posterior fully threaded positioning screw prevents femoral neck collapse in Garden I or II femoral neck fractures
Kyun-Ho Shin, Seok Ha Hong, Seung-Beom Han
SJR Q1Injury
SurgeryMedicine
11
Article|37 citations·2019
Incidence and Predictors of Lateral Hinge Fractures Following Medial Opening-Wedge High Tibial Osteotomy Using Locking Plate System: Better Performance of Computed Tomography Scans
Seung-Beom Han, Jae-Hyuk Choi, Atul Mahajan, Young-Soo Shin
SJR Q1The Journal of Arthroplasty
SurgeryMedicine
12
Article|35 citations·2010
No difference in early functional outcomes for mini‐midvastus and limited medial parapatellar approaches in navigation‐assisted total knee arthroplasty: a prospective randomized clinical trial
Dae‐Hee Lee, Jungsoon Choi, Kyung-Wook Nha, Ho‐Joong Kim, Seung-Beom Han
SJR Q1Knee Surgery Sports Traumatology Arthroscopy

Patients desire less pain and faster recovery of range of knee motion after total knee arthroplasty (TKA). While minimal invasive surgery (MIS) TKA appears to meet these needs, concerns exist regarding component malpositioning. Navigation systems can reduce the incidence of component misalignment. The present prospective randomized study compared limited medial parapatellar (LMPP) and mini-midvastus (MMV) approaches in 30 patients who had bilateral simultaneous primary TKAs. Each patient underwe

SurgeryMedicine
13
Article|33 citations·2019
Intraoperative hypotension is a risk factor for postoperative acute kidney injury after femoral neck fracture surgery: a retrospective study
Woo Young Jang, Jae-Kyun Jung, Dong Ki Lee, Seung-Beom Han
SJR Q2BMC Musculoskeletal DisordersOA

Acute kidney injury was found to occur frequently after surgery for femur neck fracture. Surgeons should be aware of acute kidney injury when planning the management of patients with femoral neck fracture and consider that the duration of intraoperative hypotension is a risk factor for acute kidney injury.

Cardiology and Cardiovascular MedicineMedicine
14
Review|29 citations·2016
Computer navigation is effective in reducing blood loss but has no effect on transfusion requirement following primary total knee arthroplasty: a meta‐analysis
Seung-Beom Han, Hyun‐Jung Kim, Tae-Kyun Kim, Yong In, Kwang-Jun Oh, In-Jun Koh, Dae‐Hee Lee
SJR Q1Knee Surgery Sports Traumatology Arthroscopy

PURPOSE: This meta-analysis was designed to evaluate the effects of computer navigation on blood conservation after total knee arthroplasty (TKA) by comparing postoperative blood loss and need for allogenic blood transfusion in patients undergoing computer navigation and conventional primary TKAs. METHODS: Studies were included in this meta-analysis if they compared change in haemoglobin concentration before and after surgery, postoperative blood loss via drainage or calculated total blood loss,

SurgeryMedicine
15
Article|28 citations·2021
Association of Preoperative Tibial Varus Deformity With Joint Line Orientation and Clinical Outcome After Open-Wedge High Tibial Osteotomy for Medial Compartment Osteoarthritis: A Propensity Score–Matched Analysis
Jun-Gu Park, Seung-Beom Han, Ki-Mo Jang
SJR Q1The American Journal of Sports Medicine

Background: The correction of lower limb deformity should be performed at the site of deformity to maintain knee joint orientation. However, the effectiveness of open-wedge high tibial osteotomy (OWHTO) for treatment of medial osteoarthritis in varus malalignment without definite tibial varus deformity has not been confirmed. Purpose/Hypothesis: This study aimed to compare the clinical and radiologic outcomes after OWHTO in patients without tibial varus deformity versus patients with tibial varu

SurgeryMedicine

Research Areas

SurgeryBiochemistryRheumatologyHealth, Toxicology and MutagenesisEpidemiologyCardiology and Cardiovascular Medicine

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